{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:03:22Z","timestamp":1787162602985,"version":"build-2736575974"},"reference-count":108,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a progressive neurological condition. The rising prevalence of AD necessitates the rapid development of efficient therapy options. Despite substantial study, only a few medications are capable of delaying the disease. Several substances with pharmacological activity, derived from plants, have been shown to have positive benefits for the treatment of AD by targeting various enzymes, such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), \u03b2-secretase, \u03b3-secretase, and monoamine oxidases (MAOs), which are discussed as potential targets. Medicinal plants have already contributed a number of lead molecules to medicine development, with many of them currently undergoing clinical trials. A variety of medicinal plants have been shown to diminish the degenerative symptoms associated with AD, either in their raw form or as isolated compounds. The aim of this review was to provide a brief summary of AD and its current therapies, followed by a discussion of the natural compounds examined as therapeutic agents and the processes underlying the positive effects, particularly the management of AD.<\/jats:p>","DOI":"10.3390\/molecules27134175","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T22:43:28Z","timestamp":1656542608000},"page":"4175","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"27","author":[{"given":"Shanshan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Convalescent Area, Ningbo Psychiatric Hospital, Ningbo 315040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianbo","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Convalescent Area, Ningbo Psychiatric Hospital, Ningbo 315040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangjing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cadre Ward, 906 Hospital of the Chinese People\u2019s Liberation Army, Ningbo 315040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guopin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Five Disease Areas, Ningbo Psychiatric Hospital, Ningbo 315040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Inspection, Ningbo Psychiatric Hospital, Ningbo 315040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sanya Central Hospital, Hainan Third People\u2019s Hospital, Sanya 572000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.biotechadv.2016.12.005","article-title":"Natural products against Alzheimer\u2019s disease: Pharmaco-therapeutics and biotechnological interventions","volume":"35","author":"Dey","year":"2017","journal-title":"Biotechnol. 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