{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:37:28Z","timestamp":1787809048979,"version":"build-2784847793"},"reference-count":44,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"Basic Science Research Program through the National Research Foundation of Korea (NRF)","doi-asserted-by":"publisher","award":["2020R1I1A3063810"],"award-info":[{"award-number":["2020R1I1A3063810"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>It has been shown that citrus flavanone naringenin and its prenyl derivative 8-prenylnaringenin (8-PN) possess various pharmacological activities in in vitro and in vivo models. Interestingly, it has been proposed that prenylation can enhance biological potentials, including the estrogen-like activities of flavonoids. The objective of this study was to investigate the anti-diabetic potential and molecular mechanism of 8-PN in streptozotocin (STZ)-induced insulin-deficient diabetic mice in comparison with naringenin reported to exhibit hypoglycemic effects. The oral administration of naringenin and 8-PN ameliorated impaired glucose homeostasis and islet dysfunction induced by STZ treatment. These protective effects were associated with the suppression of pancreatic \u03b2-cell apoptosis and inflammatory responses in mice. Moreover, both naringenin and 8-PN normalized STZ-induced insulin-signaling defects in skeletal muscles and apoptotic protein expression in the liver. Importantly, 8-PN increased the protein expression levels of estrogen receptor-\u03b1 (ER\u03b1) in the pancreas and liver and of fibroblast growth factor 21 in the liver, suggesting that 8-PN could act as an ER\u03b1 agonist in the regulation of glucose homeostasis. This study provides novel insights into the mechanisms underlying preventive effects of naringenin and 8-PN on the impairment of glucose homeostasis in insulin-deficient diabetic mice.<\/jats:p>","DOI":"10.3390\/molecules27134227","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:21:50Z","timestamp":1656634910000},"page":"4227","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Naringenin and Phytoestrogen 8-Prenylnaringenin Protect against Islet Dysfunction and Inhibit Apoptotic Signaling in Insulin-Deficient Diabetic Mice"],"prefix":"10.3390","volume":"27","author":[{"given":"Song","family":"Park","sequence":"first","affiliation":[{"name":"Department of Food Science and Biotechnology, Andong National University, Andong 36729, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Sang","family":"Sim","sequence":"additional","affiliation":[{"name":"Biomaterials Research Institute, Kyochon F&B, Andong 36729, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeop","family":"Hwangbo","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, Andong National University, Andong 36729, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Food and Biotechnology, Korea University, Sejong 30019, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food and Biotechnology, Korea University, Sejong 30019, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, Andong National University, Andong 36729, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.tifs.2018.06.012","article-title":"A recent review of citrus flavanone naringenin on metabolic diseases and its potential sources for high yield-production","volume":"79","author":"Karim","year":"2018","journal-title":"Trends Food Sci. 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