{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:41:46Z","timestamp":1793014906454,"version":"4.5.0"},"reference-count":92,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cFood for Tomorrow-Cap Aliment\u201d Research, Formation and Innovation in Pays de la Loire"},{"name":"Le Mans University"},{"name":"Conseil G\u00e9n\u00e9ral de la Mayenne"},{"name":"Laval Agglom\u00e9ration"},{"name":"CCI de la Mayenne"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Long-chain polyunsaturated fatty acids n-3 series (n-3 LC-PUFAs), especially eicosapentaenoic and docosahexaenoic acids, are known to exert preventive effects on obesity and metabolic syndrome. Mainly consumed in the form of fish oil, LC-PUFAs n-3 are also found in significant quantities in other sources such as certain microalgae. The aim of this study was to evaluate the effects of Diacronema lutheri (Dia), a microalga rich in n-3 LC-PUFAs, on metabolic disorders associated with obesity. Three groups of male Wistar rats (n = 6 per group) were submitted for eight weeks to a standard diet or high-fat and high-fructose diet (HF), supplemented or not with 12% of Dia (HF-Dia). Compared to HF rats, HF-Dia rats showed a 41% decrease in plasma triacylglycerol (TAG) and an increase in plasma cholesterol (+35%) as well as in high-density lipoprotein cholesterol (+51%) without change to low-density lipoprotein cholesterol levels. Although fasting glycemia did not change, glucose and insulin tolerance tests highlighted an improvement in glucose and insulin homeostasis. Dia supplementation restored body weight and fat mass, and decreased levels of liver TAG (\u221275%) and cholesterol (\u221284%). In HF-Dia rats, leptin was decreased (\u221230%) below the control level corresponding to a reduction of 68% compared to HF rats. Similarly, the anti-inflammatory cytokines interleukin-4 (IL-4) and IL-10 were restored up to control levels, corresponding to a 74% and 58% increase in HF rats, respectively. In contrast, the level of IL-6 remained similar in the HF and HF-Dia groups and about twice that of the control. In conclusion, these results indicated that the D. lutheri microalga may be beneficial for the prevention of weight gain and improvement in lipid and glucose homeostasis.<\/jats:p>","DOI":"10.3390\/molecules27134246","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:21:50Z","timestamp":1656634910000},"page":"4246","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Potential of the Marine Microalga Diacronema lutheri in the Prevention of Obesity and Metabolic Syndrome in High-Fat-Fed Wistar Rats"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3035-294X","authenticated-orcid":false,"given":"Claire","family":"Mayer","sequence":"first","affiliation":[{"name":"D\u00e9partement G\u00e9nie Biologique, BiOSSE, Biology of Organisms: Stress, Health, Environment, Institut Universitaire de Technologie, D\u00e9partement G\u00e9nie Biologique, Le Mans Universit\u00e9, F-53020 Laval, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"C\u00f4me","sequence":"additional","affiliation":[{"name":"D\u00e9partement G\u00e9nie Biologique, BiOSSE, Biology of Organisms: Stress, Health, Environment, Institut Universitaire de Technologie, D\u00e9partement G\u00e9nie Biologique, Le Mans Universit\u00e9, F-53020 Laval, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9009-2791","authenticated-orcid":false,"given":"Lionel","family":"Ulmann","sequence":"additional","affiliation":[{"name":"D\u00e9partement G\u00e9nie Biologique, BiOSSE, Biology of Organisms: Stress, Health, Environment, Institut Universitaire de Technologie, D\u00e9partement G\u00e9nie Biologique, Le Mans Universit\u00e9, F-53020 Laval, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Martin","sequence":"additional","affiliation":[{"name":"D\u00e9partement G\u00e9nie Biologique, BiOSSE, Biology of Organisms: Stress, Health, Environment, Institut Universitaire de Technologie, D\u00e9partement G\u00e9nie Biologique, Le Mans Universit\u00e9, F-53020 Laval, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8477-741X","authenticated-orcid":false,"given":"Graziella Chini","family":"Zittelli","sequence":"additional","affiliation":[{"name":"Department of Biology, Agriculture and Food Sciences, Institute for BioEconomy, National Research Council, Sesto Fiorentino, I-50019 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Faraloni","sequence":"additional","affiliation":[{"name":"Department of Biology, Agriculture and Food Sciences, Institute for BioEconomy, National Research Council, Sesto Fiorentino, I-50019 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Ouguerram","sequence":"additional","affiliation":[{"name":"UMR1280 PhAN, Physiopathology of Nutritional Adaptations, INRAe, CHU H\u00f4tel Dieu, IMAD, CRNH Ouest, Nantes Universit\u00e9, F-44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2441-1966","authenticated-orcid":false,"given":"Beno\u00eet","family":"Ch\u00e9nais","sequence":"additional","affiliation":[{"name":"BiOSSE, Biology of Organisms: Stress, Health, Environment, UFR Sciences et Techniques, Le Mans Universit\u00e9, F-72085 Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2468-0659","authenticated-orcid":false,"given":"Virginie","family":"Mimouni","sequence":"additional","affiliation":[{"name":"D\u00e9partement G\u00e9nie Biologique, BiOSSE, Biology of Organisms: Stress, Health, Environment, Institut Universitaire de Technologie, D\u00e9partement G\u00e9nie Biologique, Le Mans Universit\u00e9, F-53020 Laval, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2018). 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