{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:34:59Z","timestamp":1789144499965,"version":"build-2803163510"},"reference-count":217,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Romanian National Authority for Scientific Research, CNDI\u2013UEFISCDI","award":["TE 80\/01.09.2020"],"award-info":[{"award-number":["TE 80\/01.09.2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Anthocyanins are water-soluble pigments present in fruits and vegetables, which render them an extensive range of colors. They have a wide distribution in the human diet, are innocuous, and, based on numerous studies, have supposed preventive and therapeutical benefits against chronic affections such as inflammatory, neurological, cardiovascular, digestive disorders, diabetes, and cancer, mostly due to their antioxidant action. Despite their great potential as pharmaceutical applications, they have a rather limited use because of their rather low stability to environmental variations. Their absorption was noticed to occur best in the stomach and small intestine, but the pH fluctuation of the digestive system impacts their rapid degradation. Urine excretion and tissue distribution also occur at low rates. The aim of this review is to highlight the chemical characteristics of anthocyanins and emphasize their weaknesses regarding bioavailability. It also targets to deliver an update on the recent advances in the involvement of anthocyanins in different pathologies with a focus on in vivo, in vitro, animal, and human clinical trials.<\/jats:p>","DOI":"10.3390\/molecules27134254","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T20:59:18Z","timestamp":1656968358000},"page":"4254","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Anthocyanins as Key Phytochemicals Acting for the Prevention of Metabolic Diseases: An Overview"],"prefix":"10.3390","volume":"27","author":[{"given":"Madalina","family":"Nistor","sequence":"first","affiliation":[{"name":"Department of Agricultural Egineering Sciences, University of Agricultural Sciences and Veterinary Medicine, Manastur Street 3-5, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Pop","sequence":"additional","affiliation":[{"name":"Department of Agricultural Egineering Sciences, University of Agricultural Sciences and Veterinary Medicine, Manastur Street 3-5, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Daescu","sequence":"additional","affiliation":[{"name":"Department of Agricultural Egineering Sciences, University of Agricultural Sciences and Veterinary Medicine, Manastur Street 3-5, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9914-2070","authenticated-orcid":false,"given":"Adela","family":"Pintea","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Manastur Street 3-5, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-5057","authenticated-orcid":false,"given":"Carmen","family":"Socaciu","sequence":"additional","affiliation":[{"name":"Department of Agricultural Egineering Sciences, University of Agricultural Sciences and Veterinary Medicine, Manastur Street 3-5, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4881-3273","authenticated-orcid":false,"given":"Dumitrita","family":"Rugina","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Manastur Street 3-5, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.envexpbot.2015.05.012","article-title":"Multiple functional roles of anthocyanins in plant-environment interactions","volume":"119","author":"Landi","year":"2015","journal-title":"Environ. 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