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Curcumin, a natural monomer from plants has received a considerable attention as a dietary supplement, exhibiting evident activity in a wide range of human pathological conditions. In general, curcumin is beneficial to human health, demonstrating pharmacological activities of anti-inflammation and antioxidation, as well as antitumor and immune regulation activities. Curcumin also presents therapeutic potential in neurodegenerative, cardiovascular and cerebrovascular diseases. In this review article, we summarize the advancements made in recent years with respect to curcumin as a biologically active agent in malignant tumors, Alzheimer\u2019s disease (AD), hematological diseases and viral infectious diseases. We also focus on problems associated with curcumin from basic research to clinical translation, such as its low solubility, leading to poor bioavailability, as well as the controversy surrounding the association between curcumin purity and effect. Through a review and summary of the clinical research on curcumin and case reports of adverse effects, we found that the clinical transformation of curcumin is not successful, and excessive intake of curcumin may have adverse effects on the kidneys, heart, liver, blood and immune system, which leads us to warn that curcumin has a long way to go from basic research to application transformation.<\/jats:p>","DOI":"10.3390\/molecules27144400","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:06:21Z","timestamp":1657497981000},"page":"4400","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":138,"title":["A Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health"],"prefix":"10.3390","volume":"27","author":[{"given":"Siyu","family":"Liu","sequence":"first","affiliation":[{"name":"Post-Graduate School, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Post-Graduate School, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"He","sequence":"additional","affiliation":[{"name":"The First Clinical College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Liu","sequence":"additional","affiliation":[{"name":"Post-Graduate School, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Cheng","sequence":"additional","affiliation":[{"name":"The First Clinical College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangliang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Post-Graduate School, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Hunan Provincial Engineering and Technological Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine and Protecting Visual Function, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deliang","family":"Cao","sequence":"additional","affiliation":[{"name":"Post-Graduate School, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchun","family":"He","sequence":"additional","affiliation":[{"name":"Post-Graduate School, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Hunan Provincial Engineering and Technological Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine and Protecting Visual Function, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1002\/anie.201107724","article-title":"Curcumin--from molecule to biological function","volume":"51","author":"Esatbeyoglu","year":"2012","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_2","first-page":"4700","article-title":"Research progress of turmeric and prediction analysis of quality marker (Q-Marker)","volume":"52","author":"Qi","year":"2021","journal-title":"Chin. Herb. Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Vall\u00e9e, A., and Lecarpentier, Y. (2020). Curcumin and Endometriosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072440"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2019.02.020","article-title":"Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review","volume":"406","author":"Abrahams","year":"2019","journal-title":"Neuroscience"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Giordano, A., and Tommonaro, G. (2019). Curcumin and Cancer. Nutrients, 11.","DOI":"10.3390\/nu11102376"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Yang, M., Akbar, U., and Mohan, C. (2019). Curcumin in Autoimmune and Rheumatic Diseases. Nutrients, 11.","DOI":"10.3390\/nu11051004"},{"key":"ref_7","first-page":"2191","article-title":"Study on the effect and mechanism of curcumin inducing apoptosis of colon cancer LoVo cells","volume":"38","author":"Guo","year":"2013","journal-title":"Chin. J. Tradit. Chin. Med."},{"key":"ref_8","first-page":"1475","article-title":"Study on the mechanism of curcumin on the proliferation and apoptosis of colorectal cancer cells","volume":"25","author":"Liu","year":"2020","journal-title":"Mod. Dig. Interv. Diagn. Treat."},{"key":"ref_9","first-page":"1283","article-title":"Curcumin regulates the proliferation, apoptosis, migration and invasion of thyroid cancer cell TPC-1 by miR-152","volume":"38","author":"Guo","year":"2021","journal-title":"J. Guangxi Med. Univ."},{"key":"ref_10","first-page":"5615","article-title":"The mechanism of curcumin inhibiting the proliferation of human non-small cell lung cancer A549 cells and promoting apoptosis by up-regulating the expression of miR-15a\/16","volume":"39","author":"Qin","year":"2019","journal-title":"Chin. J. Geriatr."},{"key":"ref_11","first-page":"43","article-title":"Curcumin inhibits the proliferation of renal cancer A498 cells and its mechanism","volume":"32","author":"Dong","year":"2020","journal-title":"PLA Med. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3892\/etm.2021.10401","article-title":"Curcumin inhibits prostate cancer progression by regulating the miR-30a-5p\/PCLAF axis","volume":"22","author":"Pan","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"15616","DOI":"10.1002\/jcb.28828","article-title":"Modulation of miR-34a in curcumin-induced antiproliferation of prostate cancer cells","volume":"120","author":"Zhu","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00280-017-3301-1","article-title":"Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3\/miR-143 axis","volume":"79","author":"Cao","year":"2017","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_15","first-page":"1","article-title":"Curcumin Inhibits Hepatocellular Carcinoma via Regulating miR-21\/TIMP3 Axis","volume":"2020","author":"Li","year":"2020","journal-title":"Evid. Based Complement Alternat. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3389\/fphar.2017.00877","article-title":"Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt\/\u03b2-Catenin Pathways via miR-130a","volume":"8","author":"Dou","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1002\/jcb.26449","article-title":"The effects of Curcumin on HCT-116 cells proliferation and apoptosis via the miR-491\/PEG10 pathway","volume":"119","author":"Li","year":"2018","journal-title":"J. Cell Biochem."},{"key":"ref_18","first-page":"957","article-title":"Curcumin inhibits the proliferation, migration and invasion of colon cancer SW1116 cells through miR-199b-5p","volume":"36","author":"Ling","year":"2020","journal-title":"Chin. Pharmacol. Bull."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.3892\/mmr.2020.11213","article-title":"miR-192-5p upregulation mediates the suppression of curcumin in human NSCLC cell proliferation, migration and invasion by targeting c-Myc and inactivating the Wnt\/\u03b2-catenin signaling pathway","volume":"22","author":"Pan","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1142\/S0192415X18500714","article-title":"Curcumin Suppresses microRNA-7641-Mediated Regulation of p16 Expression in Bladder Cancer","volume":"46","author":"Wang","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1007\/s11255-019-02210-5","article-title":"MicroRNA-1246 regulates the radio-sensitizing effect of curcumin in bladder cancer cells via activating P53","volume":"51","author":"Xu","year":"2019","journal-title":"Int. Urol. Nephrol."},{"key":"ref_22","first-page":"64","article-title":"Curcumin affects the apoptosis of human prostate cancer PC3 cell line based on the down-regulation of the expression of miR210 and TLR4\/NF-\u03baB signaling pathway","volume":"37","author":"Ran","year":"2021","journal-title":"Pharmacol. Clin. Tradit. Chin. Med."},{"key":"ref_23","unstructured":"Qian, J.R. (2019). Role of miR-21\/PTEN\/Akt Pathway in the Anti-Gastric Cancer Effect of Curcumin and the Synergistic Effect of PD98059 against Gastric Cancer. [Ph.D. Thesis, Southern Medical University]."},{"key":"ref_24","unstructured":"Shao, J. (2017). Study on the Effect and Mechanism of Curcumin on the Regulation of miR-133a-3p-Targeted MMP15 in the Intervention of Gastric Cancer Proliferation and Metastasis. [Ph.D. Thesis, Yangzhou University]."},{"key":"ref_25","unstructured":"Sun, Q.Q. (2018). Effect of Curcumin on the Proliferation and Apoptosis of Gastric Cancer Cells Induced by miR-33b. [Master\u2019s Thesis, Zhengzhou University]."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.7314\/APJCP.2014.15.8.3363","article-title":"Induction of microRNA-9 mediates cytotoxicity of curcumin against SKOV3 ovarian cancer cells","volume":"15","author":"Zhao","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_27","first-page":"785","article-title":"Intervention of curcumin on the expression of miR-29 and VEGF in liver cancer cells","volume":"30","author":"Chen","year":"2020","journal-title":"Zhejiang J. Integr. Tradit. Chin. West. Med."},{"key":"ref_28","first-page":"254","article-title":"Curcumin regulates the expression of long-chain non-coding RNA AK125910 and mediates the apoptosis of liver cancer cells","volume":"31","author":"Guo","year":"2015","journal-title":"J. Nanjing Univ. Chin. Med."},{"key":"ref_29","first-page":"402","article-title":"Curcumin inhibits proliferation and enhances apoptosis in A549 cells by downregulating lncRNA UCA1","volume":"73","author":"Wang","year":"2018","journal-title":"Pharmazie"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1533033819870781","DOI":"10.1177\/1533033819870781","article-title":"Curcumin Regulates the Progression of Colorectal Cancer via LncRNA NBR2\/AMPK Pathway","volume":"18","author":"Yu","year":"2019","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejps.2019.04.011","article-title":"Autophagy as a molecular target for cancer treatment","volume":"134","author":"Kocaturk","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.archoralbio.2012.04.005","article-title":"Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells","volume":"57","author":"Kim","year":"2012","journal-title":"Arch. Oral Biol."},{"key":"ref_33","unstructured":"Zhu, J. (2020). Effects and Mechanisms of Extracts of Two Chinese Herbal Medicines on the Regulation of Autophagy in Colon Cancer Cells. [Ph.D. Thesis, Beijing University of Technology]."},{"key":"ref_34","first-page":"1","article-title":"Effects of curcumin on autophagy of prostate cancer cells","volume":"34","author":"Liu","year":"2021","journal-title":"J. Qiannan Natl. Med. Coll."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/s00404-019-05058-3","article-title":"Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT\/mTOR\/p70S6K pathway in human ovarian cancer cells","volume":"299","author":"Liu","year":"2019","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3892\/or.2015.4413","article-title":"Curcumin induces autophagy, inhibits proliferation and invasion by downregulating AKT\/mTOR signaling pathway in human melanoma cells","volume":"35","author":"Zhao","year":"2015","journal-title":"Oncol. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.1002\/jcp.27404","article-title":"Curcumin: A naturally occurring autophagy modulator","volume":"234","author":"Shakeri","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4196\/kjpp.2011.15.1.1","article-title":"Involvement of ROS in Curcumin-induced Autophagic Cell Death","volume":"15","author":"Lee","year":"2011","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_39","first-page":"1934578X19848179","article-title":"Curcumin Inhibits Proliferation and Migration of A549 Lung Cancer Cells Through Activation of ERK1\/2 Pathway-induced Autophagy","volume":"14","author":"Chen","year":"2019","journal-title":"Nat. Prod. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1254\/jphs.13085FP","article-title":"Curcumin Induces Autophagy via Activating the AMPK Signaling Pathway in Lung Adenocarcinoma Cells","volume":"123","author":"Xiao","year":"2013","journal-title":"J. Pharmacol. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1533033820947485","DOI":"10.1177\/1533033820947485","article-title":"Curcumin Inhibits the Migration and Invasion of Non-Small-Cell Lung Cancer Cells Through Radiation-Induced Suppression of Epithelial-Mesenchymal Transition and Soluble E-Cadherin Expression","volume":"19","author":"Deng","year":"2020","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Xu, X., Zhang, X., Zhang, Y., and Wang, Z. (2021). Curcumin suppresses the malignancy of non-small cell lung cancer by modulating the circ-PRKCA\/miR-384\/ITGB1 pathway. Biomed. Pharmacother., 138.","DOI":"10.1016\/j.biopha.2021.111439"},{"key":"ref_43","first-page":"2596","article-title":"Effects and mechanisms of curcumin on colorectal cancer cell migration, invasion and epithelial-mesenchymal transition","volume":"16","author":"Zhang","year":"2021","journal-title":"World Chin. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1002\/ijc.24593","article-title":"Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model","volume":"125","author":"Kunnumakkara","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_45","first-page":"2139","article-title":"Curcumin decreases epithelial-mesenchymal transition by a Pirin-dependent mechanism in cervical cancer cells","volume":"42","author":"Calaf","year":"2019","journal-title":"Oncol. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Babaei, G., Aziz, S.G., and Jaghi, N. (2021). EMT, cancer stem cells and autophagy; The three main axes of metastasis. Biomed. Pharmacother., 133.","DOI":"10.1016\/j.biopha.2020.110909"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"115593","DOI":"10.1016\/j.taap.2021.115593","article-title":"Molecular and clinical insights of matrix metalloproteinases into cancer spread and potential therapeutic interventions","volume":"426","author":"Siddhartha","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3892\/etm.2021.10307","article-title":"Curcumin inhibits the viability, migration and invasion of papillary thyroid cancer cells by regulating the miR-301a-3p\/STAT3 axis","volume":"22","author":"Liang","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_49","first-page":"13","article-title":"Curcumin attenuates lncRNA H19\u2011induced epithelial-mesenchymal transition in tamoxifen-resistant breast cancer cells","volume":"23","author":"Cai","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1080\/15384047.2016.1250981","article-title":"MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH\/GLI1 signaling pathway","volume":"19","author":"Yin","year":"2018","journal-title":"Cancer Biol. Ther."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fonc.2013.00090","article-title":"The tumor microenvironment: A pitch for multiple players","volume":"3","author":"Schiavoni","year":"2013","journal-title":"Front. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Buhrmann, C., Kraehe, P., Lueders, C., Shayan, P., Goel, A., and Shakibaei, M. (2014). Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: Potential role of EMT. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107514"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Kim, M.J., Park, K.-S., Kim, K.-T., and Gil, E.Y. (2020). The inhibitory effect of curcumin via fascin suppression through JAK\/STAT3 pathway on metastasis and recurrence of ovary cancer cells. BMC Womens Health, 20.","DOI":"10.1186\/s12905-020-01122-2"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0078-1","article-title":"RCP induces FAK phosphorylation and ovarian cancer cell invasion with inhibition by curcumin","volume":"50","author":"Choe","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_55","first-page":"21","article-title":"Curcumin on sarcoma cells in vitro angiogenesis mimicry and its mechanism","volume":"33","author":"Fang","year":"2020","journal-title":"West. Med."},{"key":"ref_56","first-page":"572","article-title":"Effects of curcumin combined with endostatin on growth inhibition and angiogenesis of sarcoma in mice","volume":"37","author":"Fang","year":"2020","journal-title":"Chin. J. Mod. Appl. Pharm."},{"key":"ref_57","first-page":"2531","article-title":"Curcumin induces apoptosis and inhibits angiogenesis in murine malignant mesothelioma","volume":"53","author":"Zhang","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.bbadis.2014.06.019","article-title":"Opposite angiogenic outcome of curcuminagainst ischemia and Lewis lung cancer models: In silico, in vitro and in vivo studies","volume":"1842","author":"Fan","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/cncr.31978","article-title":"Targeting autophagy using natural compounds for cancer prevention and therapy","volume":"125","author":"Deng","year":"2019","journal-title":"Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1007\/s11010-020-03856-x","article-title":"LncRNA KCNQ1OT1 is a key factor in the reversal effect of curcumin on cisplatin resistance in the colorectal cancer cells","volume":"476","author":"Zheng","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"ref_61","first-page":"109","article-title":"Study on the mechanism of curcumin reversing paclitaxel resistance in ovarian cancer cells","volume":"18","author":"Liu","year":"2021","journal-title":"J. Hunan Norm. Univ."},{"key":"ref_62","first-page":"749","article-title":"Curcumin inhibits Wnt signaling pathway and increases the sensitivity of gastric cancer cells to cisplatin","volume":"30","author":"Huang","year":"2021","journal-title":"J. Partial. Surg."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Karthika, C., Sureshkumar, R., Sajini, D.V., Ashraf, G.M., and Rahman, M.H. (2022). 5-fluorouracil and curcumin with pectin coating as a treatment regimen for titanium dioxide with dimethylhydrazine-induced colon cancer model. Environ. Sci. Pollut. Res. Int.","DOI":"10.21203\/rs.3.rs-1070585\/v1"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Shakibaei, M., Kraehe, P., Popper, B., Shayan, P., Goel, A., and Buhrmann, C. (2015). Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1291-0"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Shakibaei, M., Buhrmann, C., Kraehe, P., Shayan, P., Lueders, C., and Goel, A. (2014). Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0085397"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e505","DOI":"10.1038\/cddis.2013.26","article-title":"Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil","volume":"4","author":"Vinod","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3892\/ijo.2022.5375","article-title":"Curcumin inhibits the cancer-associated fibroblast-derived chemoresistance of gastric cancer through the suppression of the JAK\/STAT3 signaling pathway","volume":"61","author":"Ham","year":"2022","journal-title":"Int. J. Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"24675","DOI":"10.1038\/srep24675","article-title":"Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine\/NF-\u03baB signalling pathway","volume":"6","author":"Bystrup","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_69","first-page":"1343","article-title":"Curcumin attenuates resistance to irinotecan via induction of apoptosis of cancer stem cells in chemoresistant colon cancer cells","volume":"53","author":"Su","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_70","first-page":"1793","article-title":"Curcumin in vitro and in vivo reversal of 5- fluorouracil resistance in colon cancer and explore the mechanism","volume":"37","author":"Lu","year":"2020","journal-title":"Chin. J. Mod. Appl. Pharm."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"114129","DOI":"10.1016\/j.jpba.2021.114129","article-title":"Curcumin reverses doxorubicin resistance in colon cancer cells at the metabolic level","volume":"201","author":"Zhang","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/mnfr.201100270","article-title":"Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-\u03baB and NF-\u03baB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis","volume":"56","author":"Kim","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_73","unstructured":"Zhang, Y.D. (2020). Curcumin Enhances the Sensitivity of Liver Cancer Cells to Sorafenib by Inhibiting PI3K\/AKT Pathway. [Master\u2019s Thesis, Henan University]."},{"key":"ref_74","first-page":"1817","article-title":"Study on the mechanism of curcumin reversing the drug resistance of hesperidin in gastric cancer cells","volume":"53","author":"Liu","year":"2018","journal-title":"Pharm. J."},{"key":"ref_75","unstructured":"Liu, Q. (2020). Study on the Mechanism of Curcumin Combined with 5-FU Inducing Apoptosis of Gastric Cancer SGC-7901 Cells Based on Fas Signaling Pathway. [Master\u2019s Thesis, Hubei University of Chinese Medicine]."},{"key":"ref_76","first-page":"1455","article-title":"Study of curcumin reversing multi-drug resistance of Eca-109\/VCR cells in esophageal cancer through Wnt2\/\u03b2-catenin pathway","volume":"34","author":"Ren","year":"2018","journal-title":"Chin. Pharmacol. Bulletin."},{"key":"ref_77","first-page":"1192","article-title":"Study on the reversal effect and mechanism of curcumin on nejicitabine of pancreatic cancer SW1990 cells","volume":"30","author":"Peng","year":"2019","journal-title":"China Pharm."},{"key":"ref_78","unstructured":"Wang, Y.S. (2015). Curcumin on the MCF-7 Cell Resistance Regulation and Action Mechanism Research. [Master\u2019s Thesis, Chongqing Medical University]."},{"key":"ref_79","unstructured":"Wu, B. (2018). Effects of Curcumin on the Proliferation of Adriamycin-Resistant Thyroid Undifferentiated Cancer Cell Line HTh74Rdox and Its Mechanism. [Master\u2019s Thesis, Nanjing University of Traditional Chinese Medicine]."},{"key":"ref_80","unstructured":"Ren, J. (2019). Experimental Study of Curcumin Improving the Sensitivity of Paclitaxel to A549 Cells and Reducing Liver Injury. [Master\u2019s Thesis, Jiangsu University]."},{"key":"ref_81","first-page":"2855","article-title":"Research progress of radiation sensitization of curcumin on malignant tumor","volume":"35","author":"Huang","year":"2017","journal-title":"Chin. J. Tradit. Chin. Med."},{"key":"ref_82","first-page":"164","article-title":"Effect of curcumin on radiosensitivity of non-small cell lung cancer cells A549 and H460","volume":"44","author":"Zhang","year":"2020","journal-title":"Int. J. Radiat. Med. Nucl. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e196160","DOI":"10.1001\/jamanetworkopen.2019.6160","article-title":"Rate of Memory Change Before and After Cancer Diagnosis","volume":"2","author":"Abdiwahab","year":"2019","journal-title":"JAMA Netw. Open."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e2025515","DOI":"10.1001\/jamanetworkopen.2020.25515","article-title":"Association Between Alzheimer Disease and Cancer With Evaluation of Study Biases: A Systematic Review and Meta-analysis","volume":"3","author":"Glymour","year":"2020","journal-title":"JAMA Netw. Open."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41380-020-0760-2","article-title":"Cancer and Alzheimer disease inverse relationship: An age-associated diverging derailment of shared pathways","volume":"26","author":"Lanni","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-161141","article-title":"The Gut Microbiota and Alzheimer\u2019s Disease","volume":"58","author":"Jiang","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.brainresbull.2018.06.015","article-title":"Long-term effects of curcumin in the non-human primate brain","volume":"142","author":"Koo","year":"2018","journal-title":"Brain Res. Bull."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3389\/fphar.2019.00695","article-title":"Sleep and \u03b2-Amyloid Deposition in Alzheimer Disease: Insights on Mechanisms and Possible Innovative Treatments","volume":"10","author":"Cordone","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S1734-1140(11)70629-6","article-title":"Curcumin mediates presenilin-1 activity to reduce \u03b2-amyloid production in a model of Alzheimer\u2019s Disease","volume":"63","author":"Zhang","year":"2011","journal-title":"Pharmacol. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s40478-018-0577-2","article-title":"Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimer\u2019s disease brains: Implications for in-vivo diagnostics","volume":"6","author":"Morrema","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_91","first-page":"4577","article-title":"Therapeutic effect of curcumin on Alzheimer\u2019s disease mice","volume":"39","author":"Sun","year":"2019","journal-title":"Chin. J. Geriatr."},{"key":"ref_92","unstructured":"Huang, P. (2019). Study on the Mechanism of Curcumin Inhibiting the Production of \u03b2 -Amyloid Protein. [Ph.D. Thesis, Wuhan University]."},{"key":"ref_93","first-page":"1507","article-title":"In vitro study of curcumin against AD by inhibiting the activity of GSK-3\u03b2","volume":"25","author":"Zhang","year":"2009","journal-title":"Chin. Pharmacol. Bull."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1083\/jcb.101.4.1371","article-title":"The distribution of tau in the mammalian central nervous system","volume":"101","author":"Binder","year":"1985","journal-title":"J. Cell Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ijbiomac.2020.11.192","article-title":"Review on Alzheimer\u2019s disease: Inhibition of amyloid beta and tau tangle formation","volume":"167","author":"Ashrafian","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3233\/JAD-170351","article-title":"Curcumin Inhibits Tau Aggregation and Disintegrates Preformed Tau Filaments in vitro","volume":"60","author":"Rane","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_97","first-page":"2373","article-title":"Research progress of antioxidant mechanism of curcumin based on signal transduction pathway","volume":"47","author":"Li","year":"2016","journal-title":"Chin. Herb. Med."},{"key":"ref_98","first-page":"609","article-title":"Effects of curcumin on cognitive function, inflammatory response and synaptophysin expression in hippocampus of APP\/PS1 double transgenic mice","volume":"23","author":"Xia","year":"2018","journal-title":"China J. Clin. Neurosurg."},{"key":"ref_99","first-page":"1818","article-title":"Effect of curcumin on the expression of synapse-related proteins in APP\/PS1 double transgenic mice","volume":"37","author":"Wei","year":"2012","journal-title":"Chin. J. Tradit. Chin. Med."},{"key":"ref_100","first-page":"61","article-title":"The effect of curcumin on PC12 cells against oxidative damage induced by Nrf2 gene","volume":"42","author":"Ying","year":"2022","journal-title":"Chin. J. Integr. Tradit. Chin. West. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"14221","DOI":"10.1021\/jp209318f","article-title":"Scavenging mechanism of curcumin toward the hydroxyl radical: A theoretical study of reactions producing ferulic acid and vanillin","volume":"115","author":"Neha","year":"2011","journal-title":"J. Phys. Chem. A."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12937-017-0293-y","article-title":"Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: A meta-analysis of randomized controlled trials","volume":"16","author":"Qin","year":"2017","journal-title":"Nutr. J."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.nutres.2018.04.017","article-title":"Supplementation with curcumin inhibits intestinal cholesterol absorption and prevents atherosclerosis in high-fat diet\u2013fed apolipoprotein E knockout mice","volume":"56","author":"Zou","year":"2018","journal-title":"Nutr. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4162\/nrp.2010.4.3.191","article-title":"Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet","volume":"4","author":"Kim","year":"2010","journal-title":"Nutr. Res. Pract."},{"key":"ref_105","first-page":"373","article-title":"Effects of curcumin on blood lipid, inflammatory factors and endothelial function in atherosclerotic rabbits","volume":"27","author":"Fan","year":"2020","journal-title":"Sci. Technol. Tradit. Chin. Med."},{"key":"ref_106","first-page":"4471944","article-title":"Efficacy and Safety of Curcumin Supplement on Improvement of Insulin Resistance in People with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"2021","author":"Zhang","year":"2021","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_107","first-page":"143","article-title":"Curcumin promotes skeletal muscle GLUT4 translocation and improves insulin resistance in diabetic rats","volume":"37","author":"Zhu","year":"2021","journal-title":"Chin. J. Endocrinol. Metab."},{"key":"ref_108","first-page":"98","article-title":"Effect of liraglutide on the expression and mechanism of liver glycosuria key enzymes PEPCK and G6pase in diabetic mice","volume":"30","author":"Du","year":"2020","journal-title":"Chin. J. Comp. Med."},{"key":"ref_109","first-page":"32","article-title":"Study on the improvement effect and mechanism of curcumin central administration on insulin resistance mice","volume":"50","author":"Qian","year":"2019","journal-title":"Fujian Tradit. Chin. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"181","DOI":"10.5114\/ceji.2019.87070","article-title":"Therapeutic potential of curcumin in eye diseases","volume":"44","author":"Hyc","year":"2019","journal-title":"Cent. Eur. J. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Boarescu, P.M., Boarescu, I., Boc\u0219an, I.C., Gheban, D., Bulboac\u0103, A.E., Nicula, C., Pop, R.M., R\u00e2jnoveanu, R.-M., and Bolboac\u0103, S.D. (2019). Antioxidant and Anti-Inflammatory Effects of Curcumin Nanoparticles on Drug-Induced Acute Myocardial Infarction in Diabetic Rats. Antioxidants, 8.","DOI":"10.3390\/antiox8100504"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1002\/mnfr.201200540","article-title":"Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway","volume":"57","author":"Soetikno","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Lu, M., Yin, N., Liu, W., Cui, X., Chen, S., and Wang, E. (2017). Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling. Biomed Res. Int., 2017.","DOI":"10.1155\/2017\/1516985"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1002\/jcp.26249","article-title":"Curcumin, hemostasis, thrombosis, and coagulation","volume":"233","author":"Keihanian","year":"2018","journal-title":"J. Cell Physiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/ptr.5274","article-title":"Anti-platelet activity of water dispersible curcuminoids in rat platelets","volume":"29","author":"Maheswaraiah","year":"2015","journal-title":"Phytother. Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"221","DOI":"10.5483\/BMBRep.2012.45.4.221","article-title":"Anticoagulant activities of curcumin and its derivative","volume":"45","author":"Kim","year":"2012","journal-title":"BMB Rep."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.biochi.2020.09.018","article-title":"The emergence of COVID-19 as a global pandemic: Understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2","volume":"179","author":"Muralidar","year":"2020","journal-title":"Biochimie"},{"key":"ref_118","unstructured":"Wu, C.H. (2021). Inhibition of SARS-CoV-2 Infection by Extracellular Vesicles and the Effect of Curcumin on Extracellular Vesicles. [Master\u2019s Thesis, Guangzhou University of Chinese Medicine]."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1099\/jgv.0.001466","article-title":"Antiviral and virucidal effects of curcumin on transmissible gastroenteritis virus in vitro","volume":"101","author":"Li","year":"2020","journal-title":"J. Gen. Virol."},{"key":"ref_120","first-page":"534","article-title":"Experimental study of curcumin against influenza viruses H1N1 and H3N2 in vitro","volume":"9","author":"Zhang","year":"2008","journal-title":"Zhejiang J. Integr. Tradit. Chin. West. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"51163","DOI":"10.1074\/jbc.M409024200","article-title":"Curcumin, a novel p300\/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone\/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription","volume":"279","author":"Balasubramanyam","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1128\/JVI.02028-06","article-title":"Dysregulation of the ubiquitin-proteasome system by curcumin suppresses coxsackievirus B3 replication","volume":"81","author":"Si","year":"2007","journal-title":"J. Virol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.3748\/wjg.v23.i34.6252","article-title":"Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation","volume":"23","author":"Wei","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3892\/ijmm.2012.1096","article-title":"Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT","volume":"30","author":"Chen","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3332\/ecancer.2015.525","article-title":"Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer","volume":"9","author":"Mishra","year":"2015","journal-title":"Ecancermedicalscience"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"\u0160udomov\u00e1, M., and Hassan, S. (2021). Nutraceutical Curcumin with Promising Protection against Herpesvirus Infections and Their Associated Inflammation: Mechanisms and Pathways. Microorganisms, 9.","DOI":"10.3390\/microorganisms9020292"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.virol.2007.11.028","article-title":"Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300\/CBP histone acetyltransferase activity","volume":"373","author":"Kutluay","year":"2008","journal-title":"Virology"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Lv, Y., An, Z., Chen, H., Wang, Z., and Liu, L. (2014). Mechanism of curcumin resistance to human cytomegalovirus in HELF cells. BMC Complement Altern. Med., 14.","DOI":"10.1186\/1472-6882-14-284"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.antiviral.2019.04.011","article-title":"Curcumin is an APE1 redox inhibitor and exhibits an antiviral activity against KSHV replication and pathogenesis","volume":"167","author":"Li","year":"2019","journal-title":"Antiviral. Res."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Chen, T.-Y., Chen, D.-Y., Wen, H.-W., Ou, J.-L., Chiou, S.-S., Chen, J.-M., Wong, M.-L., and Hsu, W.-L. (2013). Inhibition of enveloped viruses infectivity by curcumin. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062482"},{"key":"ref_131","first-page":"744","article-title":"Research progress of curcumin pharmacokinetics and its anti-breast cancer effect","volume":"32","author":"Li","year":"2021","journal-title":"New Drugs Tradit. Chin. Med. Clin. Pharmacol."},{"key":"ref_132","first-page":"89","article-title":"The combination of lycopene and curcumin on the acute ethanol oxidative damage in mice antioxidant effects","volume":"42","author":"Fang","year":"2021","journal-title":"Cap. Med. Univ."},{"key":"ref_133","first-page":"42","article-title":"The inhibitory effect of curcumin combined with glycyrrhetinic acid on the proliferation of hepatoma HepG-2 cells","volume":"40","author":"Chang","year":"2017","journal-title":"Drug Eval. Study"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jconrel.2012.03.020","article-title":"Doxil\u00ae\u2014The first FDA-approved nano-drug: Lessons learned","volume":"160","author":"Barenholz","year":"2012","journal-title":"J. Control. Release"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"14293","DOI":"10.3390\/molecules200814293","article-title":"The Stability, Sustained Release and Cellular Antioxidant Activity of Curcumin Nanoliposomes","volume":"20","author":"Chen","year":"2015","journal-title":"Molecules"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"9141","DOI":"10.1021\/jf9013923","article-title":"Evaluation of an oral carrier system in rats: Bioavailability and antioxidant properties of liposome-encapsulated curcumin","volume":"57","author":"Takahashi","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.colsurfb.2013.10.005","article-title":"Influence of curcumin-loaded cationic liposome on anticancer activity for cervical cancer therapy","volume":"114","author":"Saengkrit","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_138","first-page":"1469","article-title":"Preparation of borneol-modified curcumin cationic liposomes and its brain targeting","volume":"38","author":"Ting","year":"2021","journal-title":"Chin. J. Mod. Appl. Pharm."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejpb.2010.09.016","article-title":"Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin","volume":"77","author":"Zhang","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ijbiomac.2018.01.063","article-title":"Development of native and modified banana starch nanoparticles as vehicles for curcumin","volume":"111","author":"Sanchez","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"16922","DOI":"10.1021\/acsami.9b02529","article-title":"Fabrication and Characterization of Layer-by-Layer Composite Nanoparticles Based on Zein and Hyaluronic Acid for Codelivery of Curcumin and Quercetagetin","volume":"11","author":"Chen","year":"2019","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Zhang, X., Chen, Z., Bao, H., Liang, J., Xu, S., Cheng, G., and Zhu, Y. (2019). Fabrication and Characterization of Silk Fibroin\/Curcumin Sustained-Release Film. Materials, 12.","DOI":"10.3390\/ma12203340"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.foodchem.2018.09.059","article-title":"Fabrication of self-assembled Radix Pseudostellariae protein nanoparticles and the entrapment of curcumin","volume":"274","author":"Weng","year":"2019","journal-title":"Food Chem."},{"key":"ref_144","first-page":"6605","article-title":"Self-Assembly of Protein Nanoparticles from Rice Bran Waste and Their Use as Delivery System for Curcumin","volume":"5","author":"Xiong","year":"2017","journal-title":"Chem. Eng."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1517\/17425247.2015.1026893","article-title":"Recent advances in cyclodextrin delivery techniques","volume":"12","author":"Arima","year":"2015","journal-title":"Expert. Opin. Drug Deliv."},{"key":"ref_146","first-page":"63","article-title":"Pharmacokinetics and Intestinal Absorption of Curcumin Chitosan Hydrochloride Coated Liposome in Rats","volume":"12","author":"Wan","year":"2021","journal-title":"Zhong Yao Cai"},{"key":"ref_147","unstructured":"Han, D.X. (2020). Study on the Mechanism of Cyclodextrin Solubilization of Small Molecular Compounds. [Master\u2019s Thesis, Shenyang Normal University]."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4143\/crt.2014.46.1.2","article-title":"Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: The golden pigment from golden spice","volume":"46","author":"Prasad","year":"2014","journal-title":"Cancer Res. Treat."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijbiomac.2019.06.060","article-title":"Understanding the cellular uptake and biodistribution of a dual-targeting carrier based on redox-sensitive hyaluronic acid-ss-curcumin micelles for treating brain glioma","volume":"136","author":"Tian","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_150","unstructured":"Zhao, M.F. (2015). Synthesis of Curcumin-Selenium Complex and Its Effect on Liver Injury Induced by Cadmium in Rats. [Master\u2019s Thesis, North China University of Science and Technology]."},{"key":"ref_151","unstructured":"Zuo, X.M. (2019). Study on the Preparation of Novel Nano-Drug Combination and Its Preparations. [Master\u2019s Thesis, Qingdao University of Science and Technology]."},{"key":"ref_152","unstructured":"Liang, Y.S. (2020). Construction and Evaluation of Ultrasound-Sensitive Tanshinone\u2013Curcumin Eutectic Complex against Otitis Media. [Master\u2019s Thesis, Guangdong Pharmaceutical University]."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"820806","DOI":"10.3389\/fphar.2022.820806","article-title":"A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin","volume":"13","author":"Fuloria","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ejps.2009.02.019","article-title":"Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer","volume":"37","author":"Shaikh","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Gandapu, U., Chaitanya, R.K., Kishore, G., Reddy, R.C., and Kondapi, A.K. (2011). Curcumin-loaded apotransferrin nanoparticles provide efficient cellular uptake and effectively inhibit HIV-1 replication in vitro. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023388"},{"key":"ref_156","first-page":"63","article-title":"Pharmacokinetic study of curcumin precursor liposome in rats","volume":"12","author":"Xu","year":"2021","journal-title":"Massage Rehabil. Med."},{"key":"ref_157","first-page":"1025","article-title":"Effects of Curcumin and Curcuma longa extract on coagulation function in thrombus model rats","volume":"40","author":"Ren","year":"2019","journal-title":"Int. J. Lab. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/ptr.6035","article-title":"Superior anticancer activity is demonstrated by total extract of Curcuma longa L. as opposed to individual curcuminoids separated by centrifugal partition chromatography","volume":"32","author":"Grabarska","year":"2018","journal-title":"Phytother Res."},{"key":"ref_159","unstructured":"(1996). Clinical development plan: Curcumin. J. Cell Biochem. Suppl., 26, 72\u201385."},{"key":"ref_160","first-page":"632","article-title":"Preliminary study on antirheumatic activity of curcumin (diferuloyl methane)","volume":"71","author":"Deodhar","year":"1980","journal-title":"Indian J. Med. Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.1158\/1078-0432.CCR-04-0744","article-title":"Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance","volume":"10","author":"Sharma","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1093\/ajcn\/87.5.1262","article-title":"Effect of cinnamon and turmeric on urinary oxalate excretion, plasma lipids, and plasma glucose in healthy subjects","volume":"87","author":"Tang","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1046\/j.1523-1755.2003.00815.x","article-title":"Effect of vitamin C supplements on urinary oxalate and pH in calcium stone-forming patients","volume":"63","author":"Baxmann","year":"2003","journal-title":"Kidney Int."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.freeradbiomed.2005.11.003","article-title":"Iron chelation in the biological activity of curcumin","volume":"40","author":"Jiao","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1182\/blood-2008-05-155952","article-title":"Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator","volume":"113","author":"Jiao","year":"2009","journal-title":"Blood"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.redox.2014.01.018","article-title":"Curcumin may impair iron status when fed to mice for six months","volume":"2","author":"Chin","year":"2014","journal-title":"Redox. Biol."},{"key":"ref_167","first-page":"6029403","article-title":"Drug Induced Liver Injury Attributed to a Curcumin Supplement","volume":"2019","author":"Imam","year":"2019","journal-title":"Case Rep. Gastrointest. Med."},{"key":"ref_168","first-page":"bcr-2018","article-title":"Drug-induced autoimmune hepatitis associated with turmeric dietary supplement use","volume":"2018","author":"Lukefahr","year":"2018","journal-title":"BMJ Case Rep."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1016\/j.ijcard.2009.09.530","article-title":"Transient complete atrioventricular block associated with curcumin intake","volume":"150","author":"Lee","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Hussaarts, K.G., Hurkmans, D.P., Hoop, E.O.-D., van Harten, L.J., Berghuis, S., van Alphen, R.J., Spierings, L.E., van Rossum-Schornagel, Q.C., Vastbinder, M.B., and van Schaik, R.H. (2019). Impact of Curcumin (with or without Piperine) on the Pharmacokinetics of Tamoxifen. Cancers, 11.","DOI":"10.3390\/cancers11030403"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1383-5718(02)00016-5","article-title":"Antimutagenic potential of curcumin on chromosomal aberrations in Wistar rats","volume":"515","author":"Shukla","year":"2002","journal-title":"Mutat Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2310\/6620.2006.06004","article-title":"Contact Urticaria from Curcumin","volume":"17","author":"Liddle","year":"2006","journal-title":"Dermatitis"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/cod.12549","article-title":"Contact dermatitis caused by turmeric in a massage oil","volume":"75","author":"Clores","year":"2016","journal-title":"Contact Dermat."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1089\/ars.2005.7.1728","article-title":"Evaluation for safety of antioxidant chemopreventive agents","volume":"7","author":"Kawanishi","year":"2005","journal-title":"Antioxid. Redox. Signal."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1093\/carcin\/bgp082","article-title":"Lung tumor promotion by curcumin","volume":"30","author":"Kock","year":"2009","journal-title":"Carcinogenesis"},{"key":"ref_176","first-page":"2895","article-title":"Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions","volume":"21","author":"Cheng","year":"2001","journal-title":"Anticancer Res."},{"key":"ref_177","first-page":"912","article-title":"Effect of curcumin combined with glibenclamide on glucose metabolism in type 2 diabetic rats and its mechanism","volume":"17","author":"Chen","year":"2014","journal-title":"Chin. Pharm."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/jcp.0b013e318160862c","article-title":"Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease","volume":"28","author":"Baum","year":"2008","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2174\/1567205053585882","article-title":"A potential role of the curry spice curcumin in Alzheimer\u2019s disease","volume":"2","author":"Ringman","year":"2005","journal-title":"Curr. Alzheimer Res."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0010-7824(03)00163-X","article-title":"Curcumin: A potential vaginal contraceptive","volume":"68","author":"Rithaporn","year":"2003","journal-title":"Contraception"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/14\/4400\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:47:06Z","timestamp":1760140026000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/14\/4400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,8]]},"references-count":180,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["molecules27144400"],"URL":"https:\/\/doi.org\/10.3390\/molecules27144400","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,8]]}}}