{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:11:06Z","timestamp":1792789866121,"version":"4.5.0"},"reference-count":45,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cFoodOmicsGR \u2013 National Research Infrastructure for the Comprehensive Characterization of Foods\u201d","award":["MIS 5029057"],"award-info":[{"award-number":["MIS 5029057"]}]},{"name":"\u201cFoodOmicsGR \u2013 National Research Infrastructure for the Comprehensive Characterization of Foods\u201d","award":["(NSRF 2014\u20132020"],"award-info":[{"award-number":["(NSRF 2014\u20132020"]}]},{"name":"Operational Programme \u201cCompetitiveness, Entrepreneurship and Innovation\u201d","award":["MIS 5029057"],"award-info":[{"award-number":["MIS 5029057"]}]},{"name":"Operational Programme \u201cCompetitiveness, Entrepreneurship and Innovation\u201d","award":["(NSRF 2014\u20132020"],"award-info":[{"award-number":["(NSRF 2014\u20132020"]}]},{"name":"Greece and the European Union (European Regional Development Fund)","award":["MIS 5029057"],"award-info":[{"award-number":["MIS 5029057"]}]},{"name":"Greece and the European Union (European Regional Development Fund)","award":["(NSRF 2014\u20132020"],"award-info":[{"award-number":["(NSRF 2014\u20132020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Honey is a highly consumed commodity due to its potential health benefits upon certain consumption, resulting in a high market price. This fact indicates the need to protect honey from fraudulent acts by delivering comprehensive analytical methodologies. In this study, targeted, suspect and non-targeted metabolomic workflows were applied to identify botanical origin markers of Greek honey. Blossom honey samples (n = 62) and the unifloral fir (n = 10), oak (n = 24), pine (n = 39) and thyme (n = 34) honeys were analyzed using an ultra-high-performance liquid chromatography hybrid quadrupole time-of-flight mass spectrometry (UHPLC-q-TOF-MS) system. Several potential authenticity markers were revealed from the application of different metabolomic workflows. In detail, based on quantitative targeted analysis, three blossom honey markers were found, namely, galangin, pinocembrin and chrysin, while gallic acid concentration was found to be significantly higher in oak honey. Using suspect screening workflow, 12 additional bioactive compounds were identified and semi-quantified, achieving comprehensive metabolomic honey characterization. Lastly, by combining non-targeted screening with advanced chemometrics, it was possible to discriminate thyme from blossom honey and develop binary discriminatory models with high predictive power. In conclusion, a holistic approach to assessing the botanical origin of Greek honey is presented, highlighting the complementarity of the three applied metabolomic approaches.<\/jats:p>","DOI":"10.3390\/molecules27144444","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T03:50:36Z","timestamp":1657597836000},"page":"4444","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Thorough Investigation of the Phenolic Profile of Reputable Greek Honey Varieties: Varietal Discrimination and Floral Markers Identification Using Liquid Chromatography\u2013High-Resolution Mass Spectrometry"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2599-1456","authenticated-orcid":false,"given":"Georgios A.","family":"Koulis","sequence":"first","affiliation":[{"name":"Analytical Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15771 Athens, Greece"},{"name":"Food Chemistry Laboratory, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15771 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4450-2611","authenticated-orcid":false,"given":"Aristeidis S.","family":"Tsagkaris","sequence":"additional","affiliation":[{"name":"Department of Food Analysis and Nutrition, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technick\u00e1 5, 16628 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota A.","family":"Katsianou","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15771 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis-Loukas P.","family":"Gialouris","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15771 Athens, Greece"},{"name":"Food Chemistry Laboratory, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15771 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Martakos","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15771 Athens, Greece"},{"name":"Food Chemistry Laboratory, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15771 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotis","family":"Stergiou","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15771 Athens, Greece"},{"name":"Division of Engineering and Food Science, School of Applied Science, Abertay University, Bell Street, Dundee DD1 1HG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9490-0090","authenticated-orcid":false,"given":"Alberto","family":"Fiore","sequence":"additional","affiliation":[{"name":"Division of Engineering and Food Science, School of Applied Science, Abertay University, Bell Street, Dundee DD1 1HG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9790-7252","authenticated-orcid":false,"given":"Eleni I.","family":"Panagopoulou","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15771 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Karabournioti","sequence":"additional","affiliation":[{"name":"Attiki Honey SA, Kryoneri Attikis, 14568 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0472-771X","authenticated-orcid":false,"given":"Carsten","family":"Baessmann","sequence":"additional","affiliation":[{"name":"Bruker Daltonik GmbH, Fahrenheitstra\u00dfe 4, 28359 Bremen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noud","family":"van der Borg","sequence":"additional","affiliation":[{"name":"Bruker Daltonik GmbH, Fahrenheitstra\u00dfe 4, 28359 Bremen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0853-4547","authenticated-orcid":false,"given":"Marilena E.","family":"Dasenaki","sequence":"additional","affiliation":[{"name":"Food Chemistry Laboratory, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15771 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3450-5969","authenticated-orcid":false,"given":"Charalampos","family":"Proestos","sequence":"additional","affiliation":[{"name":"Food Chemistry Laboratory, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15771 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4624-4735","authenticated-orcid":false,"given":"Nikolaos S.","family":"Thomaidis","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15771 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1017\/S0954422419000192","article-title":"Therapeutic and preventive properties of honey and its bioactive compounds in cancer: An evidence-based review","volume":"33","author":"Afrin","year":"2020","journal-title":"Nutr. 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