{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:33:27Z","timestamp":1791329607939,"version":"4.3.1"},"reference-count":56,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Statutory Funds of the Medical University of Lublin provided by the Polish Ministry of Science and Higher Education","award":["DS43 AB-K"],"award-info":[{"award-number":["DS43 AB-K"]}]},{"name":"the Statutory Funds of the Medical University of Lublin provided by the Polish Ministry of Science and Higher Education","award":["2017\/01\/X\/NZ6\/01001"],"award-info":[{"award-number":["2017\/01\/X\/NZ6\/01001"]}]},{"DOI":"10.13039\/501100004281","name":"National Science Centre, Poland","doi-asserted-by":"publisher","award":["DS43 AB-K"],"award-info":[{"award-number":["DS43 AB-K"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"National Science Centre, Poland","doi-asserted-by":"publisher","award":["2017\/01\/X\/NZ6\/01001"],"award-info":[{"award-number":["2017\/01\/X\/NZ6\/01001"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nicolaus Copernicus University, Collegium Medicum","award":["DS43 AB-K"],"award-info":[{"award-number":["DS43 AB-K"]}]},{"name":"Nicolaus Copernicus University, Collegium Medicum","award":["2017\/01\/X\/NZ6\/01001"],"award-info":[{"award-number":["2017\/01\/X\/NZ6\/01001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Parasitic diseases, caused by intestinal helminths, remain a very serious problem in both human and veterinary medicine. While searching for new nematicides we examined a series of 1,2,4-triazole derivatives 9\u201322, obtained during reactions of N3-substituted amidrazones with itaconic anhydride. Two groups of compounds, 9\u201316 and 17\u201322, differed in the position of the double bond on the methacrylic acid moiety. The toxicity of derivatives 9\u201322 and the anti-inflammatory activity of 12 and 19\u201322 were studied on peripheral blood mononuclear cells (PBMC). Antiproliferative activity of compounds 12 and 19\u201322 was tested cytometrically in PBMC cultures stimulated by phytohemagglutinin. The influence of derivatives 12 and 19\u201322 on the TNF-\u03b1, IL-6, IL-10 and IFN-\u03b3 production was determined by ELISA in lipopolysaccharide-stimulated PBMC cultures. Anthelmintic activity of compounds 10\u201322 was studied in the Rhabditis sp. nematodes model. Most compounds (11\u201322) proved to be non-toxic to human PBMC. Derivatives 19\u201322 showed anti-inflammatory activity by inhibiting the proliferation of lymphocytes. Moreover, compounds 12 and 19\u201322 significantly reduced the production of TNF-\u03b1 and derivatives 19\u201321 decreased the level of INF-\u03b3. The strongest anti-inflammatory activity was observed for compound 21. Compounds 12 and 14 demonstrated anthelmintic activity higher than albendazole and may become promising candidates for anthelmintic drugs.<\/jats:p>","DOI":"10.3390\/molecules27144488","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:12:40Z","timestamp":1657757560000},"page":"4488","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Evaluation of Anthelmintic and Anti-Inflammatory Activity of 1,2,4-Triazole Derivatives"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1217-879X","authenticated-orcid":false,"given":"Renata","family":"Paprocka","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, Jurasza Str. 2, 85-089 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3710-0860","authenticated-orcid":false,"given":"Przemys\u0142aw","family":"Ko\u0142odziej","sequence":"additional","affiliation":[{"name":"Chair and Department of Biology and Genetics, Faculty of Pharmacy, Medical University in Lublin, Chod\u017aki Str. 4A, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Wiese-Szadkowska","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, M. Curie-Sklodowska Str. 9, 85-094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Helmin-Basa","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, M. Curie-Sklodowska Str. 9, 85-094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-7429","authenticated-orcid":false,"given":"Anna","family":"Bogucka-Kocka","sequence":"additional","affiliation":[{"name":"Chair and Department of Biology and Genetics, Faculty of Pharmacy, Medical University in Lublin, Chod\u017aki Str. 4A, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6669742","DOI":"10.1155\/2021\/6669742","article-title":"Prevalence of Intestinal Parasite Infections and Their Associated Factors among Food Handlers Working in Selected Catering Establishments from Bule Hora, Ethiopia","volume":"2021","author":"Hajare","year":"2021","journal-title":"BioMed Res. 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