{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:23:56Z","timestamp":1791638636673,"version":"4.3.4"},"reference-count":103,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>As the most common cancer in women, efforts have been made to develop novel nanomedicine-based therapeutics for breast cancer. In the present study, the in silico curcumin (Cur) properties were investigated, and we found some important drawbacks of Cur. To enhance cancer therapeutics of Cur, three different nonionic surfactants (span 20, 60, and 80) were used to prepare various Cur-loaded niosomes (Nio-Cur). Then, fabricated Nio-Cur were decorated with folic acid (FA) and polyethylene glycol (PEG) for breast cancer suppression. For PEG-FA@Nio-Cur, the gene expression levels of Bax and p53 were higher compared to free drug and Nio-Cur. With PEG-FA-decorated Nio-Cur, levels of Bcl2 were lower than the free drug and Nio-Cur. When MCF7 and 4T1 cell uptake tests of PEG-FA@Nio-Cur and Nio-Cur were investigated, the results showed that the PEG-FA-modified niosomes exhibited the most preponderant endocytosis. In vitro experiments demonstrate that PEG-FA@Nio-Cur is a promising strategy for the delivery of Cur in breast cancer therapy. Breast cancer cells absorbed the prepared nanoformulations and exhibited sustained drug release characteristics.<\/jats:p>","DOI":"10.3390\/molecules27144634","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T03:34:40Z","timestamp":1658374480000},"page":"4634","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Folate-Targeted Curcumin-Loaded Niosomes for Site-Specific Delivery in Breast Cancer Treatment: In Silico and In Vitro Study"],"prefix":"10.3390","volume":"27","author":[{"given":"Banafsheh","family":"Honarvari","sequence":"first","affiliation":[{"name":"Department of Physics, Faculty of Physics and Chemistry, Alzahra University, Tehran 1993893973, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Karimifard","sequence":"additional","affiliation":[{"name":"Central Tehran Branch, Stem Cells Research Center, Tissue Engineering and Regenerative Medicine Institute, Islamic Azad University, Tehran 1568937813, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niyayesh","family":"Akhtari","sequence":"additional","affiliation":[{"name":"Department of Biology, Parand Branch, Islamic Azad University, Parand 3761396361, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6892-7019","authenticated-orcid":false,"given":"Mehrnoush","family":"Mehrarya","sequence":"additional","affiliation":[{"name":"Protein Research Center, Shahid Beheshti University, Tehran 1983969411, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra Salehi","family":"Moghaddam","sequence":"additional","affiliation":[{"name":"Department of Microbial Biotechnology, School of Biology, College of Science, University of Tehran, Tehran 141556455, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Javed","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 16278, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8403-7465","authenticated-orcid":false,"given":"Abduladheem Turki","family":"Jalil","sequence":"additional","affiliation":[{"name":"Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla 51001, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8203-0673","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Matencio","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Turin, Via Pietro Giuria 7, 10125 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Trotta","sequence":"additional","affiliation":[{"name":"Department of 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Sciences, Tehran 19835178, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8305-7234","authenticated-orcid":false,"given":"Mohammad Reza","family":"Naimi-Jamal","sequence":"additional","affiliation":[{"name":"Research Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry, Iran University of Science and Technology, Tehran 1684611367, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Noorbazargan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra Asghari","family":"Lalami","sequence":"additional","affiliation":[{"name":"Department of Biology, Parand Branch, Islamic Azad University, Parand 3761396361, 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