{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T02:12:38Z","timestamp":1770516758490,"version":"3.49.0"},"reference-count":37,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Poznan University of Life Sciences","award":["508.782.03.00"],"award-info":[{"award-number":["508.782.03.00"]}]},{"name":"Poznan University of Life Sciences","award":["0511\/SBAD\/2251"],"award-info":[{"award-number":["0511\/SBAD\/2251"]}]},{"name":"Ministry of Science &amp; Higher Education in Poland","award":["508.782.03.00"],"award-info":[{"award-number":["508.782.03.00"]}]},{"name":"Ministry of Science &amp; Higher Education in Poland","award":["0511\/SBAD\/2251"],"award-info":[{"award-number":["0511\/SBAD\/2251"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Phospholipid membranes are ubiquitous components of cells involved in physiological processes; thus, knowledge regarding their interactions with other molecules, including tocopherol ester derivatives, is of great importance. The surface pressure\u2013area isotherms of pure \u03b1-tocopherol (Toc) and its derivatives (oxalate (OT), malonate (MT), succinate (ST), and carbo analog (CT)) were studied in Langmuir monolayers in order to evaluate phase formation, compressibility, packing, and ordering. The isotherms and compressibility results indicate that, under pressure, the ester derivatives and CT are able to form two-dimensional liquid-condensed (LC) ordered structures with collapse pressures ranging from 27 mN\/m for CT to 44 mN\/m for OT. Next, the effect of length of ester moiety on the surface behavior of DPPC\/Toc derivatives\u2019 binary monolayers at air\u2013water interface was investigated. The average molecular area, elastic modulus, compressibility, and miscibility were calculated as a function of molar fraction of derivatives. Increasing the presence of Toc derivatives in DPPC monolayer induces expansion of isotherms, increased monolayer elasticity, interrupted packing, and lowered ordering in monolayer, leading to its fluidization. Decreasing collapse pressure with increasing molar ratio of derivatives indicates on the miscibility of Toc esters in DPPC monolayer. The interactions between components were analyzed using additivity rule and thermodynamic calculations of excess and total Gibbs energy of mixing. Calculated excess area and Gibbs energy indicated repulsion between components, confirming their partial mixing. In summary, the mechanism of the observed phenomena is mainly connected with interactions of ionized carboxyl groups of ester moieties with DPPC headgroup moieties where formed conformations perturb alignment of acyl chains, resulting in increasing mean area per molecule, leading to disordering and fluidization of mixed monolayer.<\/jats:p>","DOI":"10.3390\/molecules27154670","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T03:58:44Z","timestamp":1658462324000},"page":"4670","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Ester Moiety on Structural Properties of Binary Mixed Monolayers of Alpha-Tocopherol Derivatives with DPPC"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8398-7143","authenticated-orcid":false,"given":"Gra\u017cyna","family":"Neunert","sequence":"first","affiliation":[{"name":"Department of Physics and Biophysics, Faculty of Food Science and Nutrition, Poznan University of Life Sciences, Wojska Polskiego 38\/42, 60-637 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Hertmanowski","sequence":"additional","affiliation":[{"name":"Institute of Materials Research and Quantum Engineering, Faculty of Materials Engineering and Technical Physics, Poznan University of Technology, Piotrowo 3, 60-965 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislaw","family":"Witkowski","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0445-7721","authenticated-orcid":false,"given":"Krzysztof","family":"Polewski","sequence":"additional","affiliation":[{"name":"Department of Physics and Biophysics, Faculty of Food Science and Nutrition, Poznan University of Life Sciences, Wojska Polskiego 38\/42, 60-637 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/0006-291X(82)91787-9","article-title":"Interaction of vitamin E with saturated phospholipid bilayers","volume":"106","author":"Massey","year":"1982","journal-title":"Biochem. 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