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The use of cheap and easy-to-handle Na2S\u00b79H2O as the reductant in the presence of PPh3 and N-chlorosuccinimide (NCS) enables the selective dehydroxylation of \u03b1-hydroxyl carbonyl compounds, including ketones, esters, amides, imides and nitrile groups. The synthetic utility is demonstrated by the late-stage deoxygenation of bioactive molecule and complex natural products.<\/jats:p>","DOI":"10.3390\/molecules27154675","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T01:42:13Z","timestamp":1658713333000},"page":"4675","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Na2S-Mediated One-Pot Selective Deoxygenation of \u03b1-Hydroxyl Carbonyl Compounds including Natural Products"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0380-8702","authenticated-orcid":false,"given":"Xiaobo","family":"Xu","sequence":"first","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyu","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Kai","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqing","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuangwen","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyue","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Yan","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.1016\/j.bmc.2009.05.019","article-title":"Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins","volume":"17","author":"Ng","year":"2009","journal-title":"Bioorg. 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