{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T05:16:28Z","timestamp":1771737388536,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"Korean National Research Foundation","doi-asserted-by":"publisher","award":["2020R1A2C1014112"],"award-info":[{"award-number":["2020R1A2C1014112"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"Korean National Research Foundation","doi-asserted-by":"publisher","award":["2022-0081"],"award-info":[{"award-number":["2022-0081"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Seoul Women\u2019s University","award":["2020R1A2C1014112"],"award-info":[{"award-number":["2020R1A2C1014112"]}]},{"name":"Seoul Women\u2019s University","award":["2022-0081"],"award-info":[{"award-number":["2022-0081"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Among various volatile organic compounds (VOCs) emitted from human skin, trans-2-nonenal, benzothiazole, hexyl salicylate, \u03b1-hexyl cinnamaldehyde, and isopropyl palmitate are key indicators associated with the degrees of aging. In our study, extraction and determination methods of human body odor are newly developed using headspace-in needle microextraction (HS-INME). The adsorbent was synthesized with graphene oxide:polyaniline\/zinc nanorods\/zeolitic imidazolate framework-8 (GO:PANI\/ZNRs\/ZIF\u22128). Then, a wire coated with the adsorbent was placed into the adsorption kit to be directly exposed to human skin as in vivo sampling and inserted into the needle so that it was able to be desorbed at the GC injector. The adsorption kit was made in-house with a 3D printer. For the in vitro method, the wire coated with the adsorbent was inserted into the needle and exposed to the headspace of the vial. When a cotton T-shirt containing body odor was transferred to a vial, the headspace of the vial was saturated with body odor VOCs. After volatile organic compounds were adsorbed in the dynamic mode, the needle was transferred to the injector for analysis of the volatile organic compounds by gas chromatography\/mass spectrometry (GC\/MS). The conditions of adsorbent fabrication and extraction for body odor compounds were optimized by response surface methodology (RSM). In conclusion, it was able to synthesize GO:PANI\/ZNRs\/ZIF\u22128 at the optimal condition and applicable to both in vivo and in vitro methods for body odor VOCs analysis.<\/jats:p>","DOI":"10.3390\/molecules27154795","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T03:21:16Z","timestamp":1658978476000},"page":"4795","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["In Vitro and In Vivo Human Body Odor Analysis Method Using GO:PANI\/ZNRs\/ZIF\u22128 Adsorbent Followed by GC\/MS"],"prefix":"10.3390","volume":"27","author":[{"given":"Sehyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Chemistry, Seoul Women\u2019s University, 621 Hwarang-ro, Nowon-gu, Seoul 01797, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6236-1109","authenticated-orcid":false,"given":"Sunyoung","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Seoul Women\u2019s University, 621 Hwarang-ro, Nowon-gu, Seoul 01797, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1046\/j.0022-202x.2001.01287.x","article-title":"2-NonenalNewly Found in Human Body Odor Tends to Increase with Aging","volume":"116","author":"Haze","year":"2001","journal-title":"J. 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