{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:59:50Z","timestamp":1789167590564,"version":"build-2803163510"},"reference-count":165,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda (CONACYT)","doi-asserted-by":"publisher","award":["1043251"],"award-info":[{"award-number":["1043251"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda (CONACYT)","doi-asserted-by":"publisher","award":["A1-S-8616"],"award-info":[{"award-number":["A1-S-8616"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The marine environment is highly diverse, each living creature fighting to establish and proliferate. Among marine organisms, cyanobacteria are astounding secondary metabolite producers representing a wonderful source of biologically active molecules aimed to communicate, defend from predators, or compete. Studies on these molecules\u2019 origins and activities have been systematic, although much is still to be discovered. Their broad chemical diversity results from integrating peptide and polyketide synthetases and synthases, along with cascades of biosynthetic transformations resulting in new chemical structures. Cyanobacteria are glycolipid, macrolide, peptide, and polyketide producers, and to date, hundreds of these molecules have been isolated and tested. Many of these compounds have demonstrated important bioactivities such as cytotoxicity, antineoplastic, and antiproliferative activity with potential pharmacological uses. Some are currently under clinical investigation. Additionally, conventional chemotherapeutic treatments include drugs with a well-known range of side effects, making anticancer drug research from new sources, such as marine cyanobacteria, necessary. This review is focused on the anticancer bioactivities of metabolites produced by marine cyanobacteria, emphasizing the identification of each variant of the metabolite family, their chemical structures, and the mechanisms of action underlying their biological and pharmacological activities.<\/jats:p>","DOI":"10.3390\/molecules27154814","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T03:21:16Z","timestamp":1658978476000},"page":"4814","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Marine Cyanobacteria as Sources of Lead Anticancer Compounds: A Review of Families of Metabolites with Cytotoxic, Antiproliferative, and Antineoplastic Effects"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5692-4067","authenticated-orcid":false,"given":"Benjam\u00edn","family":"Robles-Ba\u00f1uelos","sequence":"first","affiliation":[{"name":"Facultad de Farmacia, Universidad Aut\u00f3noma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, Cuernavaca C.P. 62209, Mexico"},{"name":"Laboratorio de Amino\u00e1cidos Excitadores\/Laboratorio de Neurofarmacolog\u00eda Molecular y Nanotecnolog\u00eda, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, Insurgentes Sur 3877, Mexico City 14269, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8805-7228","authenticated-orcid":false,"given":"Lorena Mar\u00eda","family":"Dur\u00e1n-Riveroll","sequence":"additional","affiliation":[{"name":"CONACYT\u2014Departamento de Biotecnolog\u00eda Marina, Centro de Investigaci\u00f3n Cient\u00edfica y Educaci\u00f3n Superior de Ensenada, Baja Cailifornia, Carr. Tijuana-Ensenada 3918, Zona Playitas, Ensenada 22860, Mexico"},{"name":"Alfred Wegener Institut-Helmholtz Zentrum F\u00fcr Polar- Und Meeresforschung, Am Handelshafen 12, 27579 Bremerhaven, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4741-1793","authenticated-orcid":false,"given":"Edgar","family":"Rangel-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratorio de Amino\u00e1cidos Excitadores\/Laboratorio de Neurofarmacolog\u00eda Molecular y Nanotecnolog\u00eda, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, Insurgentes Sur 3877, Mexico City 14269, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8217-1169","authenticated-orcid":false,"given":"Hugo Isidro","family":"P\u00e9rez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnolog\u00eda Marina, Centro de Investigaci\u00f3n Cient\u00edfica y Educaci\u00f3n Superior de Ensenada, Baja California, Carr. Tijuana-Ensenada 3918, Zona Playitas, Ensenada 22860, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4456-1235","authenticated-orcid":false,"given":"Leticia","family":"Gonz\u00e1lez-Maya","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia, Universidad Aut\u00f3noma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, Cuernavaca C.P. 62209, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.2174\/1871520616666160211123841","article-title":"Novel therapeutic strategies against cancer: Marine-derived drugs may be the answer?","volume":"16","author":"Riccioni","year":"2016","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Demay, J., Bernard, C., Reinhardt, A., and Marie, B. (2019). 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