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Targeting multiple cancer hallmarks is a promising strategy to treat cancer. The diversity in chemical structure and the relatively low toxicity make plant-derived natural products a promising source for the development of new and more effective anticancer therapies that have the capacity to target multiple hallmarks in cancer. In this review, we discussed the anticancer activities of ten natural products extracted from plants. The majority of these products inhibit cancer by targeting multiple cancer hallmarks, and many of these chemicals have reached clinical applications. Studies discussed in this review provide a solid ground for researchers and physicians to design more effective combination anticancer therapies using plant-derived natural products.<\/jats:p>","DOI":"10.3390\/molecules27154818","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T03:21:16Z","timestamp":1658978476000},"page":"4818","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Plants as a Source of Anticancer Agents: From Bench to Bedside"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1942-8982","authenticated-orcid":false,"given":"Wamidh H.","family":"Talib","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1958-6534","authenticated-orcid":false,"given":"Safa","family":"Daoud","sequence":"additional","affiliation":[{"name":"Department Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Applied Science Private University, Amman 11931, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4591-7408","authenticated-orcid":false,"given":"Asma Ismail","family":"Mahmod","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem Ali","family":"Hamed","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1300-3353","authenticated-orcid":false,"given":"Dima","family":"Awajan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Feras","family":"Abuarab","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena Hisham","family":"Odeh","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Khater","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Therapeutic, Applied Science Private University, Amman 11931, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-7655","authenticated-orcid":false,"given":"Lina T.","family":"Al Kury","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, College of Natural and Health Sciences, Zayed University, Abu Dhabi 144534, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1001\/jamaoncol.2021.6987","article-title":"Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: A systematic analysis for the Global Burden of Disease Study 2019","volume":"8","author":"Kocarnik","year":"2022","journal-title":"JAMA Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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