{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T07:32:13Z","timestamp":1792308733355,"version":"4.4.0"},"reference-count":41,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Major Science and Technology Projects in Henan Province","award":["171100310500"],"award-info":[{"award-number":["171100310500"]}]},{"name":"The Major Science and Technology Projects in Henan Province","award":["2019YFC1708802"],"award-info":[{"award-number":["2019YFC1708802"]}]},{"name":"The Major Science and Technology Projects in Henan Province","award":["82104386"],"award-info":[{"award-number":["82104386"]}]},{"name":"The Major Science and Technology Projects in Henan Province","award":["212102310345"],"award-info":[{"award-number":["212102310345"]}]},{"name":"National Key Research and Development Project","award":["171100310500"],"award-info":[{"award-number":["171100310500"]}]},{"name":"National Key Research and Development Project","award":["2019YFC1708802"],"award-info":[{"award-number":["2019YFC1708802"]}]},{"name":"National Key Research and Development Project","award":["82104386"],"award-info":[{"award-number":["82104386"]}]},{"name":"National Key Research and Development Project","award":["212102310345"],"award-info":[{"award-number":["212102310345"]}]},{"name":"National Natural Science Foundation of China","award":["171100310500"],"award-info":[{"award-number":["171100310500"]}]},{"name":"National Natural Science Foundation of China","award":["2019YFC1708802"],"award-info":[{"award-number":["2019YFC1708802"]}]},{"name":"National Natural Science Foundation of China","award":["82104386"],"award-info":[{"award-number":["82104386"]}]},{"name":"National Natural Science Foundation of China","award":["212102310345"],"award-info":[{"award-number":["212102310345"]}]},{"name":"Scientific and technological key project in Henan Province","award":["171100310500"],"award-info":[{"award-number":["171100310500"]}]},{"name":"Scientific and technological key project in Henan Province","award":["2019YFC1708802"],"award-info":[{"award-number":["2019YFC1708802"]}]},{"name":"Scientific and technological key project in Henan Province","award":["82104386"],"award-info":[{"award-number":["82104386"]}]},{"name":"Scientific and technological key project in Henan Province","award":["212102310345"],"award-info":[{"award-number":["212102310345"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Five new triterpenoids, oenotheralanosterols C-G (1\u20135), with seven known triterpenoidcompounds, namely 2\u03b1,3\u03b1,19\u03b1-trihydroxy-24-norurs4,12-dien-28-oic acid (6), 3\u03b2,23-dihydroxy-1-oxo-olean-12-en-28-oic acid (7), remangilone C (8), knoxivalic acid A (9), termichebulolide (10), rosasecotriterpene A (11), androsanortriterpene C (12), were extracted and separated from the dichloromethane part of Oenothera biennis L. The anti-pulmonary fibrosis activities of all the compounds against TGF-\u03b21-induced damage tonormal human lung epithelial (BEAS-2B) cells were investigated in vitro. The results showed that compounds 1\u20132, 6, 8, and 11 exhibited significant anti-pulmonary fibrosis activities, with EC50 values ranging from 4.7 \u03bcM to 9.9 \u03bcM.<\/jats:p>","DOI":"10.3390\/molecules27154870","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T04:04:00Z","timestamp":1659326640000},"page":"4870","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anti-Pulmonary Fibrosis Activities of Triterpenoids from Oenothera biennis"],"prefix":"10.3390","volume":"27","author":[{"given":"Juanjuan","family":"Liu","sequence":"first","affiliation":[{"name":"College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingke","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnan","family":"Zeng","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9633-9257","authenticated-orcid":false,"given":"Meng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisheng","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"ref_1","first-page":"712","article-title":"Progress in evaluation and development of drugs for treatment of pulmonary fibrosis","volume":"30","author":"Deng","year":"2021","journal-title":"Chin. 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