{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:50:16Z","timestamp":1790117416486,"version":"4.0.1"},"reference-count":95,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF) grants funded by the Korean Government","award":["NRF-2019R1A2C2002923"],"award-info":[{"award-number":["NRF-2019R1A2C2002923"]}]},{"name":"National Research Foundation of Korea (NRF) grants funded by the Korean Government","award":["NRF-2022R1A4A1018930"],"award-info":[{"award-number":["NRF-2022R1A4A1018930"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Molineria recurvata (MR) has been traditionally used to manage diabetes mellitus in India. However, the molecular mechanism of MR on the diabetic-induced nephropathy has not been clearly investigated. Thus, this study investigates the protective effects of the MR extract on nephropathy in streptozotocin (STZ)-induced diabetic rats. Diabetes was instigated by a single intraperitoneal injection of STZ (45 mg\/kg) in male Sprague-Dawley rats. Once the diabetes was successfully induced, the MR extract (200 mg\/kg\/day) or metformin (200 mg\/kg\/day) was orally administered for 14 days. Renal function, morphology changes and levels of inflammatory cytokines were measured. Blood glucose concentrations were considerably reduced in STZ-induced diabetic rats following treatment with the MR extract. The administration of the MR extract substantially restored the abnormal quantity of the oxidative DNA damage marker 8-hydroxy-2\u2032-deoxy-guanosine (8-OHdG), malondialdehyde, glutathione, oxidized glutathione, superoxide dismutase, catalase, interleukin (IL)-1\u03b2, IL-6, IL-10, and transforming growth factor-\u03b2 (TGF-\u03b2). The urinary excretion of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), selenium binding protein 1 (SBP1), and pyruvate kinase M2 (PKM2) was significantly reduced in diabetes rats after administration of the MR extracts. In the kidneys of STZ-induced diabetic rats, the MR extracts markedly downregulated the expression of fibronectin, collagen-1, and \u03b1-smooth muscle actin (\u03b1-SMA). In particular, the MR extracts markedly increased the level of SIRT1 and SIRT3 and reduced claudin-1 in the kidney. These results suggest that the MR extracts exhibits therapeutic activity in contrast to renal injury in STZ-induced diabetic rats through repressing inflammation and oxidative stress.<\/jats:p>","DOI":"10.3390\/molecules27154985","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T22:33:11Z","timestamp":1659997991000},"page":"4985","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Molineria recurvata Ameliorates Streptozotocin-Induced Diabetic Nephropathy through Antioxidant and Anti-Inflammatory Pathways"],"prefix":"10.3390","volume":"27","author":[{"given":"Prasanta","family":"Dey","sequence":"first","affiliation":[{"name":"School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon 16419, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kundu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon 16419, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon 16419, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babli","family":"Kar","sequence":"additional","affiliation":[{"name":"Bengal Homoeopathic Medical College and Hospital, Asansol 713301, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0641-4979","authenticated-orcid":false,"given":"Vineet","family":"Vishal","sequence":"additional","affiliation":[{"name":"Department of Botany, Bangabasi Evening College, Kolkata 700009, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvakanta","family":"Dash","sequence":"additional","affiliation":[{"name":"Regional Institute of Pharmaceutical Science & Technology, Agartala 799006, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2665-9431","authenticated-orcid":false,"given":"In Su","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon 16419, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejendra","family":"Bhakta","sequence":"additional","affiliation":[{"name":"Regional Institute of Pharmaceutical Science & Technology, Agartala 799006, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7657-3970","authenticated-orcid":false,"given":"Hyung Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon 16419, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.2040-1124.2010.00018.x","article-title":"Molecular mechanisms of diabetic vascular complications","volume":"1","author":"Kitada","year":"2010","journal-title":"J. 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