{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T09:17:43Z","timestamp":1782119863231,"version":"3.54.5"},"reference-count":74,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco (FACEPE)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Biomphalaria glabrata snails constitute the main vector of schistosomiasis in Brazil, and Bauhinia monandra Kurz, the leaves of which contain BmoLL lectin with biocidal action, is a plant widely found on continents in which the disease is endemic. This work describes the composition of B. monandra preparations and the effect on embryos and adult snails, their reproduction parameters and hemocytes. We also describe the results of a comet assay after B. glabrata exposure to sublethal concentrations of the preparations. Additionally, the effects of the preparations on S. mansoni cercariae and environmental monitoring with Artemia salina are described. In the chemical evaluation, cinnamic, flavonoid and saponin derivatives were detected in the two preparations assessed, namely the saline extract and the fraction. Both preparations were toxic to embryos in the blastula, gastrula, trochophore, veliger and hippo stages (LC50 of 0.042 and 0.0478; 0.0417 and 0.0419; 0.0897 and 0.1582; 0.3734 and 0.0974; 0.397 and 0.0970 mg\/mL, respectively) and to adult snails (LC50 of 6.6 and 0.87 mg\/mL, respectively), which were reproductively affected with decreased egg deposition. In blood cell analysis, characteristic cells for apoptosis, micronucleus and binucleation were detected, while for comet analysis, different degrees of nuclear damage were detected. The fraction was able to cause total mortality of the cercariae and did not present environmental toxicity. Therefore, B. monandra preparations are promising in combating schistosomiasis since they can control both the intermediate host and eliminate the infectious agent, besides being safe to the environment.<\/jats:p>","DOI":"10.3390\/molecules27154993","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T22:33:11Z","timestamp":1659997991000},"page":"4993","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Bauhinia monandra Kurz Leaf Preparations on Embryonic Stages and Adult Snails of Biomphalaria glabrata (Say, 1818), Schistosoma mansoni Cercariae and Toxicity in Artemia salina"],"prefix":"10.3390","volume":"27","author":[{"given":"Thierry Wesley de Albuquerque","family":"Aguiar","sequence":"first","affiliation":[{"name":"Centro de Bioci\u00eancias, Departamento de Bioqu\u00edmica, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, Cidade Universit\u00e1ria, n 1235, Recife 50670-420, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Josenildo","family":"Batista","sequence":"additional","affiliation":[{"name":"Centro de Bioci\u00eancias, Departamento de Bioqu\u00edmica, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, Cidade Universit\u00e1ria, n 1235, Recife 50670-420, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio Assis de Oliveira","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Centro de Bioci\u00eancias, Departamento de Bioqu\u00edmica, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, Cidade Universit\u00e1ria, n 1235, Recife 50670-420, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00edra de Vasconcelos Lima","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Centro de Bioci\u00eancias, Departamento de Biof\u00edsica e Radiobiologia, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, Cidade Universit\u00e1ria, n 1235, Recife 50670-420, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewson Rocha","family":"Pereira","sequence":"additional","affiliation":[{"name":"Centro de Bioci\u00eancias, Departamento de Biof\u00edsica e Radiobiologia, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, Cidade Universit\u00e1ria, n 1235, Recife 50670-420, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda Rhayanny Assun\u00e7\u00e3o","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias da Sa\u00fade, Departamento de Ci\u00eancias Farmac\u00eauticas, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Arthur de S\u00e1, Cidade Universit\u00e1ria, s\/n, Recife 50740-521, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Alberto Lira","family":"Soares","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias da Sa\u00fade, Departamento de Ci\u00eancias Farmac\u00eauticas, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Arthur de S\u00e1, Cidade Universit\u00e1ria, s\/n, Recife 50740-521, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria Mendon\u00e7a de Albuquerque","family":"Melo","sequence":"additional","affiliation":[{"name":"Centro de Bioci\u00eancias, Departamento de Biof\u00edsica e Radiobiologia, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, Cidade Universit\u00e1ria, n 1235, Recife 50670-420, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica Camelo Pessoa de Azevedo","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias M\u00e9dicas\u2014\u00c1rea Acad\u00eamica de Medicina Tropical, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, Cidade Universit\u00e1ria, n 531-611, Recife 50670-901, PE, Brazil"},{"name":"Laborat\u00f3rio de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, Cidade Universit\u00e1ria, n 1235, Recife 50670-901, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9283-1466","authenticated-orcid":false,"given":"Andr\u00e9 de Lima","family":"Aires","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias M\u00e9dicas\u2014\u00c1rea Acad\u00eamica de Medicina Tropical, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, Cidade Universit\u00e1ria, n 531-611, Recife 50670-901, PE, Brazil"},{"name":"Laborat\u00f3rio de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, Cidade Universit\u00e1ria, n 1235, Recife 50670-901, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-1655","authenticated-orcid":false,"given":"Hallysson Douglas Andrade de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Centro de Bioci\u00eancias, Departamento de Bioqu\u00edmica, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, Cidade Universit\u00e1ria, n 1235, Recife 50670-420, PE, Brazil"},{"name":"Laborat\u00f3rio de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, Cidade Universit\u00e1ria, n 1235, Recife 50670-901, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Cassandra Breitenbach Barroso","family":"Coelho","sequence":"additional","affiliation":[{"name":"Centro de Bioci\u00eancias, Departamento de Bioqu\u00edmica, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego, Cidade Universit\u00e1ria, n 1235, Recife 50670-420, 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