{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T01:52:46Z","timestamp":1782352366688,"version":"3.54.5"},"reference-count":73,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T00:00:00Z","timestamp":1659830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Foundation for Basic Research","award":["19-53-53008 GFEN_a"],"award-info":[{"award-number":["19-53-53008 GFEN_a"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A bright far-red emitting unsymmetrical meso-CF3-BODIPY fluorescent dye with phenyl and pyrazolyl substituents was synthesized by condensation of trifluoropyrrolylethanol with pyrazolyl-pyrrole, with subsequent oxidation and complexation of the formed dipyrromethane. This BODIPY dye exhibits optical absorption at \u03bbab \u2248 610\u2013620 nm and emission at \u03bbem \u2248 640\u2013650 nm. The BODIPY was studied on Ehrlich carcinoma cells as a lysosome-specific fluorescent dye that allows intravital staining of cell structures with subsequent real-time monitoring of changes occurring in the cells. It was also shown that the rate of uptake by cells, the rate of intracellular transport into lysosomes, and the rate of saturation of cells with the dye depend on its concentration in the culture medium. A concentration of 5 \u03bcM was chosen as the most suitable BODIPY concentration for fluorescent staining of living cell lysosomes, while a concentration of 100 \u03bcM was found to be toxic to Ehrlich carcinoma cells.<\/jats:p>","DOI":"10.3390\/molecules27155018","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T22:33:11Z","timestamp":1659997991000},"page":"5018","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Application of meso-CF3-Fluorophore BODIPY with Phenyl and Pyrazolyl Substituents for Lifetime Visualization of Lysosomes"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0270-404X","authenticated-orcid":false,"given":"Irina S.","family":"Trukhan","sequence":"first","affiliation":[{"name":"Irkutsk Scientific Center of Surgery and Traumatology, 664003 Irkutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis N.","family":"Tomilin","sequence":"additional","affiliation":[{"name":"A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Science, 664033 Irkutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2540-4525","authenticated-orcid":false,"given":"Nataliya N.","family":"Dremina","sequence":"additional","affiliation":[{"name":"Irkutsk Scientific Center of Surgery and Traumatology, 664003 Irkutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyubov N.","family":"Sobenina","sequence":"additional","affiliation":[{"name":"A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Science, 664033 Irkutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5921-0318","authenticated-orcid":false,"given":"Michael G.","family":"Shurygin","sequence":"additional","affiliation":[{"name":"Irkutsk Scientific Center of Surgery and Traumatology, 664003 Irkutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin B.","family":"Petrushenko","sequence":"additional","affiliation":[{"name":"A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Science, 664033 Irkutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0860-8913","authenticated-orcid":false,"given":"Igor K.","family":"Petrushenko","sequence":"additional","affiliation":[{"name":"Irkutsk National Research Technical University, 664074 Irkutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris A.","family":"Trofimov","sequence":"additional","affiliation":[{"name":"A.E. 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