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University","award":["BS406"],"award-info":[{"award-number":["BS406"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a major neurodegenerative disease, but so far, it can only be treated symptomatically rather than changing the process of the disease. Recently, triazoles and their derivatives have been shown to have potential for the treatment of AD. In this study, the neuroprotective effects of 4-(4-(heptyloxy)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (W112) against \u03b2-amyloid (A\u03b2)-induced AD pathology and its possible mechanism were explored both in vitro and in vivo. The results showed that W112 exhibits a neuroprotective role against A\u03b2-induced cytotoxicity in PC12 cells and improves the learning and memory abilities of A\u03b2-induced AD-like rats. In addition, the assays of the protein expression revealed that W112 reversed tau hyperphosphorylation and reduced the production of proinflammatory cytokines, tumor necrosis factor-\u03b1 and interleukin-6, both in vitro and in vivo studies. Further study indicated that the regulation of mitogen-activated protein kinase\/nuclear factor-\u03baB pathways played a key role in mediating the neuroprotective effects of W112 against AD-like pathology. W112 may become a potential drug for AD intervention.<\/jats:p>","DOI":"10.3390\/molecules27155035","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T22:33:11Z","timestamp":1659997991000},"page":"5035","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Anti-Inflammatory Activity of 4-(4-(Heptyloxy)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one via Repression of MAPK\/NF-\u03baB Signaling Pathways in \u03b2-Amyloid-Induced Alzheimer\u2019s Disease Models"],"prefix":"10.3390","volume":"27","author":[{"given":"Fengmao","family":"An","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Chemistry and Pharmacology, Inner Mongolia Minzu University, Tongliao 028000, China"},{"name":"Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao 028000, China"},{"name":"Medical College, Inner Mongolia Minzu University, Tongliao 028000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinran","family":"Xuan","sequence":"additional","affiliation":[{"name":"First Clinical Medical College, Inner Mongolia Minzu University, Tongliao 028000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yanbian University, Yanji 133002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Bian","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Chemistry and Pharmacology, Inner Mongolia Minzu University, Tongliao 028000, China"},{"name":"Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao 028000, China"},{"name":"Medical College, Inner Mongolia Minzu University, Tongliao 028000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingkun","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yanbian University, Yanji 133002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheshan","family":"Quan","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yanbian University, Yanji 133002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Nursing, Inner Mongolia Minzu University, Tongliao 028000, China"},{"name":"Institute of Dementia, Inner Mongolia Minzu University, Tongliao 028000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengxi","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Chemistry and Pharmacology, Inner Mongolia Minzu University, Tongliao 028000, China"},{"name":"Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao 028000, China"},{"name":"Medical College, Inner Mongolia Minzu University, Tongliao 028000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer\u2019s disease","volume":"25","author":"Lane","year":"2018","journal-title":"Eur. 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