{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:57:55Z","timestamp":1787029075562,"version":"build-2736575974"},"reference-count":40,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this paper, the organocatalytic asymmetric Michael addition\/hemiketalization cascade reactions between hydroxymaleimides and 2-hydroxynitrostyrenes were developed, which provided a new protocol for building a chiral ring-fused chroman skeleton. This squaramide-catalyzed cascade reaction provided chiral chroman-fused pyrrolidinediones with three contiguous stereocenters in good to high yields (up to 88%), with excellent diastereoselectivities (up to &gt;20:1 dr) and enantioselectivities (up to 96% ee) at \u221216 \u00b0C. Moreover, a scale-up synthesis was also carried out, and a possible reaction mechanism was proposed.<\/jats:p>","DOI":"10.3390\/molecules27165081","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T09:42:56Z","timestamp":1660124576000},"page":"5081","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Enantioselective Michael\/Hemiketalization Cascade Reactions between Hydroxymaleimides and 2-Hydroxynitrostyrenes for the Construction of Chiral Chroman-Fused Pyrrolidinediones"],"prefix":"10.3390","volume":"27","author":[{"given":"Dong-Hua","family":"Xie","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Niu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9924-5117","authenticated-orcid":false,"given":"Da-Ming","family":"Du","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1002\/ejoc.200500936","article-title":"New \u03b1-glucosidase inhibitors and antibacterial compounds from Myrtus communis L.","volume":"2006","author":"Shaheen","year":"2006","journal-title":"Eur. 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