{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T02:31:23Z","timestamp":1776738683153,"version":"3.51.2"},"reference-count":13,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"COSMAX BTI"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The skin tissue of the scalp is unique from other skin tissues because it coexists with hair, and many differences in microbial composition have been confirmed. In scalp tissues, hair loss occurs due to a combination of internal and external factors, and several studies are being conducted to counteract this. However, not many studies have addressed hair loss from the perspective of the microbiome. In this study, subjects with hair loss and those with normal scalps were set as experimental and control groups, respectively. In the experimental group, hair loss had progressed, and there was a large difference in microbiome composition compared to the group with normal scalps. In particular, differences in Accumulibacter, Staphylococcus, and Corynebacterium were found. From Staphylococcus epidermidis Cicaria, two active components were isolated as a result of repeated column chromatography. Spectroscopic data led to the determination of chemical structures for adenosine and biotin. Fractions were obtained, and ex vivo tests were conducted using hair follicles derived from human scalp tissue. When the microbiome adenosine-treated group was compared to the control group, hair follicle length was increased, and hair root diameter was maintained during the experimental periods. In addition, the Cicaria culture medium and the microbial adenosine- and biotin-treated groups maintained the anagen phase, reducing progression to the catagen phase in the hair growth cycle. In conclusion, it was confirmed that the Cicaria culture medium and the microbial adenosine and biotin derived from the culture were effective in inhibiting hair loss.<\/jats:p>","DOI":"10.3390\/molecules27165136","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T03:33:20Z","timestamp":1660534400000},"page":"5136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Staphylococcus epidermidis Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss"],"prefix":"10.3390","volume":"27","author":[{"given":"HyungWoo","family":"Jo","sequence":"first","affiliation":[{"name":"COSMAX BTI, R&I Center, Seongnam 13486, Gyeonggi, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon Yu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Biotechnology, College of Life Science, Kyung Hee University, Yongin 17104, Gyeonggi, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Ha","family":"Kang","sequence":"additional","affiliation":[{"name":"COSMAX, Seongnam 13486, Pangyo-ro, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaeyun","family":"Baek","sequence":"additional","affiliation":[{"name":"COSMAX BTI, R&I Center, Seongnam 13486, Gyeonggi, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8672-8024","authenticated-orcid":false,"given":"Jeong Eun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Biotechnology, College of Life Science, Kyung Hee University, Yongin 17104, Gyeonggi, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Woo","family":"Jeang","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Biotechnology, College of Life Science, Kyung Hee University, Yongin 17104, Gyeonggi, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Mok","family":"Heo","sequence":"additional","affiliation":[{"name":"COSMAX BTI, R&I Center, Seongnam 13486, Gyeonggi, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4551-4964","authenticated-orcid":false,"given":"Hye-Been","family":"Kim","sequence":"additional","affiliation":[{"name":"COSMAX BTI, R&I Center, Seongnam 13486, Gyeonggi, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9003-7365","authenticated-orcid":false,"given":"Chan Yeong","family":"Heo","sequence":"additional","affiliation":[{"name":"H&BIO Corporation\/R&D Center, Seongnam 13605, Gyeonggi, Korea"},{"name":"Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam 13620, Gyeonggi, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Min","family":"Kang","sequence":"additional","affiliation":[{"name":"Korean Skin Research Center (KSRC), Seongnam 13558, Gyeonggi, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Ho","family":"Shin","sequence":"additional","affiliation":[{"name":"Korean Skin Research Center (KSRC), Seongnam 13558, Gyeonggi, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da Yeong","family":"Nam","sequence":"additional","affiliation":[{"name":"Korean Skin Research Center (KSRC), Seongnam 13558, Gyeonggi, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9133-5783","authenticated-orcid":false,"given":"Yeong-Geun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Biotechnology, College of Life Science, Kyung Hee University, Yongin 17104, Gyeonggi, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0790-2237","authenticated-orcid":false,"given":"Se Chan","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Biotechnology, College of Life Science, Kyung Hee University, Yongin 17104, Gyeonggi, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Geol","family":"Lee","sequence":"additional","affiliation":[{"name":"COSMAX BTI, R&I Center, Seongnam 13486, Gyeonggi, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s40257-018-0405-2","article-title":"The Medical and Psychosocial Associations of Alopecia: Recognizing Hair Loss as More Than a Cosmetic Concern","volume":"20","author":"Marks","year":"2019","journal-title":"Am. 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