{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:39:58Z","timestamp":1789670398227,"version":"4.0.1"},"reference-count":68,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jain University","award":["58269-ND1"],"award-info":[{"award-number":["58269-ND1"]}]},{"name":"ACSPRF-ND","award":["58269-ND1"],"award-info":[{"award-number":["58269-ND1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Coumarins are fused six-membered oxygen-containing benzoheterocycles that join two synthetically useful rings: \u03b1-pyrone and benzene. A survey of the literature shows that coumarins and their metal complexes have received great interest from synthetic chemists, medicinal scientists, and pharmacists due to their wide spectrum of biological applications. For instance, coumarin and its derivatives have been used as precursors to prepare a large variety of medicinal agents. Likewise, coumarin-derived imine\u2013metal complexes have been found to display a variety of therapeutic applications, such as antibacterial, antifungal, anticancer, antioxidant, anthelmintic, pesticidal, and nematocidal activities. This review highlights the current synthetic methodologies and known bioactivities of coumarin-derived imine\u2013metal complexes that make this molecule a more attractive scaffold for the discovery of newer drugs.<\/jats:p>","DOI":"10.3390\/molecules27165220","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T03:15:27Z","timestamp":1660706127000},"page":"5220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Comprehensive Review on Medicinal Applications of Coumarin-Derived Imine\u2013Metal Complexes"],"prefix":"10.3390","volume":"27","author":[{"given":"Siddappa A.","family":"Patil","sequence":"first","affiliation":[{"name":"Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Bangalore 562112, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0720-8264","authenticated-orcid":false,"given":"Vishal","family":"Kandathil","sequence":"additional","affiliation":[{"name":"Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Bangalore 562112, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Sobha","sequence":"additional","affiliation":[{"name":"Organic Chemistry Section, Chemical Sciences & Technology Division, National Institute for Interdisciplinary Science and Technology (CSIR), Thiruvananthapuram 695019, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1546-2083","authenticated-orcid":false,"given":"Sasidhar B.","family":"Somappa","sequence":"additional","affiliation":[{"name":"Organic Chemistry Section, Chemical Sciences & Technology Division, National Institute for Interdisciplinary Science and Technology (CSIR), Thiruvananthapuram 695019, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max R.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Chemistry & Physics, Florida Gulf Coast University, 10501 FGCU Boulevard South, Fort Myers, FL 33965, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8504-355X","authenticated-orcid":false,"given":"Alejandro","family":"Bugarin","sequence":"additional","affiliation":[{"name":"Department of Chemistry & Physics, Florida Gulf Coast University, 10501 FGCU Boulevard South, Fort Myers, FL 33965, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivaputra A.","family":"Patil","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Department, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Stefanachi, A., Leonetti, F., Pisani, L., Catto, M., and Carotti, A. 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