{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:39:39Z","timestamp":1785796779128,"version":"3.56.0"},"reference-count":88,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico (DGAPA-UNAM)","award":["PAPIIT IN308120"],"award-info":[{"award-number":["PAPIIT IN308120"]}]},{"name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico (DGAPA-UNAM)","award":["CVU 706595"],"award-info":[{"award-number":["CVU 706595"]}]},{"name":"osgrado en Ciencias Biol\u00f3gicas, UNAM; and Consejo Nacional de Ciencia y Tecnolog\u00eda","award":["PAPIIT IN308120"],"award-info":[{"award-number":["PAPIIT IN308120"]}]},{"name":"osgrado en Ciencias Biol\u00f3gicas, UNAM; and Consejo Nacional de Ciencia y Tecnolog\u00eda","award":["CVU 706595"],"award-info":[{"award-number":["CVU 706595"]}]},{"name":"Programa para la Investigaci\u00f3n Bibliogr\u00e1fica Cient\u00edfica sobre Salud (PIBCIS) de la FES Zaragoza, UNAM","award":["PAPIIT IN308120"],"award-info":[{"award-number":["PAPIIT IN308120"]}]},{"name":"Programa para la Investigaci\u00f3n Bibliogr\u00e1fica Cient\u00edfica sobre Salud (PIBCIS) de la FES Zaragoza, UNAM","award":["CVU 706595"],"award-info":[{"award-number":["CVU 706595"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Background: Several clinical trials have suggested that resveratrol has hypoglycemic properties; however, there are other studies in which such an effect has not been observed. Methods: We carried out a systematic search in several databases; seventeen studies were selected for the systematic review and fifteen were included in the meta-analysis. Results: Resveratrol decreases glucose levels in subjects aged 45\u201359 years at doses &lt;250 mg\/day (\u22128.64 mg\/dL, p &lt; 0.00001), 250\u2013500 mg\/day (\u221222.24 mg\/dL, p = 0.0003), and 500\u20131000 mg\/day (\u221228.40 mg\/dL, p = 0.0008), while in subjects older than 60 years, it only decreases with doses of 250\u2013500 mg\/day. Likewise, HbA1c improved in subjects aged 45\u201359 years with doses of 250\u2013500 mg (\u22120.60%, p &lt; 0.00001), but not in subjects older than 60 years. Insulin levels improved in subjects aged 45\u201359 years with doses &lt; 250 mg\/day (\u22120.80 mIU\/L, p = 0.0003) and doses of 250\u2013500 mg\/day (\u22125.0 mIU\/L, p = 0.0003), although in subjects older than 60 years, they only improved with doses of 250\u2013500 mg\/day (\u22121.79 mIU\/L, p = 0.01). On the other hand, HOMA-IR only improved in subjects older than 60 years with doses of 250\u2013500 mg\/day (\u22120.40, p = 0.01). Conclusions: Resveratrol has a statistically significant dose\u2013response effect on glucose concentrations, HbA1c, and insulin levels; however, there is not enough scientific evidence to propose a therapeutic dose.<\/jats:p>","DOI":"10.3390\/molecules27165232","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T03:15:27Z","timestamp":1660706127000},"page":"5232","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Influence of Age and Dose on the Effect of Resveratrol for Glycemic Control in Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1815-3537","authenticated-orcid":false,"given":"Beatriz Isabel","family":"Garc\u00eda-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Research Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, Mexico City 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirna","family":"Ruiz-Ramos","sequence":"additional","affiliation":[{"name":"Research Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, Mexico City 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6628-4411","authenticated-orcid":false,"given":"Jos\u00e9","family":"Pedraza-Chaverri","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico (UNAM), Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4876-0688","authenticated-orcid":false,"given":"Edelmiro","family":"Santiago-Osorio","sequence":"additional","affiliation":[{"name":"Hematopoiesis and Leukemia Laboratory, Research Unit on Cell Differentiation and Cancer, FES Zaragoza, National Autonomous University of Mexico, Mexico City 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9137-3405","authenticated-orcid":false,"given":"V\u00edctor Manuel","family":"Mendoza-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Research Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, Mexico City 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3389\/fimmu.2020.01582","article-title":"The effects of type 2 diabetes mellitus on organ metabolism and the immune system","volume":"11","author":"Daryabor","year":"2020","journal-title":"Front. 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