{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:21:53Z","timestamp":1790677313169,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Euromed University of Fes"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In the present study, new 2-phenyl-5,6,7,8-tetrahydroimidazo [1,2-b]pyridazines bearing sulfonamides were synthesized, characterized and evaluated for their anticancer activities. The structures of these derivatives were elucidated by 1H NMR, 13C NMR, infrared and high-resolution mass spectrometry for further validation of the target compound structures. The anticancer activities of the new molecules were evaluated against five human cancer cell lines, including A-549, Hs-683, MCF-7, SK-MEL-28 and B16-F10 cell lines using 5-fluorouracil and etoposide as the reference drugs. Among the tested compounds, 4e and 4f exhibited excellent activities in the same range of the positive controls, 5-fluorouracil and etoposide, against MCF-7 and SK-MEL-28 cancer cell lines, with IC50 values ranging from 1 to 10 \u03bcM. The molecular docking studies of 4e and 4f showed a strong binding with some kinases, which are linked to MCF-7 and SK-MEL-28 cancer cell lines.<\/jats:p>","DOI":"10.3390\/molecules27165238","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T03:15:27Z","timestamp":1660706127000},"page":"5238","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Synthesis, Anticancer Activities and Molecular Docking Studies of a Novel Class of 2-Phenyl-5,6,7,8-tetrahydroimidazo [1,2-b]pyridazine Derivatives Bearing Sulfonamides"],"prefix":"10.3390","volume":"27","author":[{"given":"Otmane","family":"Bourzikat","sequence":"first","affiliation":[{"name":"Euromed Research Center, Euromed Faculty of Pharmacy, Euromed University of Fes (UEMF), Meknes Road, Fez 30000, Morocco"},{"name":"Institut de Chimie Organique et Analytique, Universit\u00e9 d\u2019Orl\u00e9ans, UMR CNRS 7311, BP 6759, CEDEX 2, 45067 Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0296-4044","authenticated-orcid":false,"given":"Abdelmoula","family":"El Abbouchi","sequence":"additional","affiliation":[{"name":"Euromed Research Center, Euromed Faculty of Pharmacy, Euromed University of Fes (UEMF), Meknes Road, Fez 30000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Ghammaz","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique et Technique (CNRST), Angle Avenues des FAR et Allal El Fassi, Hay Ryad, Rabat 10102, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"El Brahmi","sequence":"additional","affiliation":[{"name":"Euromed Research Center, Euromed Faculty of Pharmacy, Euromed University of Fes (UEMF), Meknes Road, Fez 30000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmostfa","family":"El Fahime","sequence":"additional","affiliation":[{"name":"Euromed Research Center, Euromed Faculty of Pharmacy, Euromed University of Fes (UEMF), Meknes Road, Fez 30000, Morocco"},{"name":"Centre National de la Recherche Scientifique et Technique (CNRST), Angle Avenues des FAR et Allal El Fassi, Hay Ryad, Rabat 10102, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-549X","authenticated-orcid":false,"given":"Arnaud","family":"Paris","sequence":"additional","affiliation":[{"name":"Institut de Chimie Organique et Analytique, Universit\u00e9 d\u2019Orl\u00e9ans, UMR CNRS 7311, BP 6759, CEDEX 2, 45067 Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7296-3736","authenticated-orcid":false,"given":"Richard","family":"Daniellou","sequence":"additional","affiliation":[{"name":"Institut de Chimie Organique et Analytique, Universit\u00e9 d\u2019Orl\u00e9ans, UMR CNRS 7311, BP 6759, CEDEX 2, 45067 Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1394-1603","authenticated-orcid":false,"given":"Franck","family":"Suzenet","sequence":"additional","affiliation":[{"name":"Institut de Chimie Organique et Analytique, Universit\u00e9 d\u2019Orl\u00e9ans, UMR CNRS 7311, BP 6759, CEDEX 2, 45067 Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rald","family":"Guillaumet","sequence":"additional","affiliation":[{"name":"Euromed Research Center, Euromed Faculty of Pharmacy, Euromed University of Fes (UEMF), Meknes Road, Fez 30000, Morocco"},{"name":"Institut de Chimie Organique et Analytique, Universit\u00e9 d\u2019Orl\u00e9ans, UMR CNRS 7311, BP 6759, CEDEX 2, 45067 Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5021-3571","authenticated-orcid":false,"given":"Sa\u00efd","family":"El Kazzouli","sequence":"additional","affiliation":[{"name":"Euromed Research Center, Euromed Faculty of Pharmacy, Euromed University of Fes (UEMF), Meknes Road, Fez 30000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ejmech.2018.10.037","article-title":"Research advances on anticancer activities of matrine and its derivatives: An updated overview","volume":"161","author":"Xu","year":"2019","journal-title":"Eur. 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