{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:58:23Z","timestamp":1768438703664,"version":"3.49.0"},"reference-count":87,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Poverty Alleviation by Science and Technology in Sichuan Province","award":["2017NFP0080"],"award-info":[{"award-number":["2017NFP0080"]}]},{"name":"Poverty Alleviation by Science and Technology in Sichuan Province","award":["202000092"],"award-info":[{"award-number":["202000092"]}]},{"name":"Poverty Alleviation by Science and Technology in Sichuan Province","award":["QNXZ2018041"],"award-info":[{"award-number":["QNXZ2018041"]}]},{"name":"Administration for market regulation of Chengdu (Chengdu Intellectual Property Administration)","award":["2017NFP0080"],"award-info":[{"award-number":["2017NFP0080"]}]},{"name":"Administration for market regulation of Chengdu (Chengdu Intellectual Property Administration)","award":["202000092"],"award-info":[{"award-number":["202000092"]}]},{"name":"Administration for market regulation of Chengdu (Chengdu Intellectual Property Administration)","award":["QNXZ2018041"],"award-info":[{"award-number":["QNXZ2018041"]}]},{"name":"Chengdu University of Traditional Chinese Medicine","award":["2017NFP0080"],"award-info":[{"award-number":["2017NFP0080"]}]},{"name":"Chengdu University of Traditional Chinese Medicine","award":["202000092"],"award-info":[{"award-number":["202000092"]}]},{"name":"Chengdu University of Traditional Chinese Medicine","award":["QNXZ2018041"],"award-info":[{"award-number":["QNXZ2018041"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The application of the seed oil of Prunus mira Koehne (Tibetan name \u0f41\u0f58\u0f56\u0f74\u0f0d), a plant belonging to the Rosaceae family, for the treatment of alopecia has been recorded in Jingzhu Materia Medica (\u0f64\u0f7a\u0f63\u0f0b\u0f42\u0f7c\u0f44\u0f0b\u0f64\u0f7a\u0f63\u0f0b\u0f55\u0fb2\u0f7a\u0f44\u0f0b\u0f0d) (the classic of Tibetan medicine) and Dictionary of Chinese Ethnic Medicine. This study aims to reveal the effective components and mechanism of hair growth promotion in the kernel of Prunus mira Koehne. Network pharmacology was used to predict the mechanism of action and effective components in the treatment of the kernel of Prunus mira Koehne. The contents of amygdalin in 12 batches of the kernel of Prunus mira Koehne were determined by HPLC. An animal model of the depilation of KM mice induced by sodium sulfide was created, and five effective components that promoted hair growth were initially screened. In the study of the effectiveness and mechanism of action, KM and C57BL\/6 mice are selected as experimental objects, three screening tests for active components of the kernel of P. mira are performed, and three effective components are screened out from the eight components. HE staining was used to detect the number of hair follicles and the thickness of the dermis. RT-PCR and immunohistochemistry were used to evaluate the influence of the expression of indicators in the Wnt\/\u03b2-catenin signaling pathway in skin, including \u03b2-catenin, GSK-3\u03b2, and mRNA and protein expression levels of Cyclin D 1 and LEF 1. The network pharmacology study showed 12 signaling pathways involving 25 targets in the treatment of alopecia by the kernel of Prunus mira Koehne. vitamin E (3.125 mg\/cm2\/d), \u03b2-sitosterol (0.061 mg\/cm2\/d), and linoleic acid (0.156 mg\/cm2\/d) in the kernel of Prunus mira Koehne can promote hair growth in mice, and the mechanism of action may be related to the Wnt\/\u03b2-catenin pathway.<\/jats:p>","DOI":"10.3390\/molecules27165242","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T22:53:30Z","timestamp":1660776810000},"page":"5242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Identification of Hair Growth Promoting Components in the Kernels of Prunus mira Koehne and Their Mechanism of Action"],"prefix":"10.3390","volume":"27","author":[{"given":"You","family":"Zhou","sequence":"first","affiliation":[{"name":"College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanyue","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijun","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Ethnomedicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Ethnomedicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1411-6365","authenticated-orcid":false,"given":"Hongxiang","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Ethnomedicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6169-1755","authenticated-orcid":false,"given":"Zhang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Ethnomedicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"ref_1","unstructured":"Ga, W. 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