{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:43:52Z","timestamp":1790995432638,"version":"4.1.0"},"reference-count":86,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>For centuries, traditional medicine from plants (phytotherapy) was the only treatment for infectious and non-infectious diseases. Although it is still practiced in several countries with excellent therapeutic results, it is frequently underestimated because, unlike Western medicine, it is not based on an empirical scientific foundation. However, interest in the search for plant-based therapeutic resources has been stimulated by disciplines such as phytochemistry and the side effects of conventional pharmacological therapies. For example, Larrea tridentata is a perennial shrub used in traditional medicine in northern Mexico and the southern United States to treat infertility, rheumatism, arthritis, colds, diarrhea, skin problems, pain, inflammation and excess body weight. Scientific research has revealed its beneficial effects\u2014antioxidant, antitumor, neuroprotective, regenerative, antibacterial, antiviral, antifungal, anthelmintic, antiprotozoal and insecticidal\u2014although reports indicate that some compounds in Larrea tridentata may be hepatotoxic and nephrotoxic. Therefore, the aim of this review was to highlight the updates regarding phytochemical compounds and the pharmacological properties of Larrea tridentata.<\/jats:p>","DOI":"10.3390\/molecules27175393","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T23:48:58Z","timestamp":1661384938000},"page":"5393","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Phytochemical Compounds and Pharmacological Properties of Larrea tridentata"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9542-8242","authenticated-orcid":false,"given":"Ana Lizet","family":"Morales-Ubaldo","sequence":"first","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuarias, Universidad Aut\u00f3noma del Estado de Hidalgo, Rancho Universitario Av. Universidad km 1, EX-Hda de Aquetzalpa, Tulancingo 43600, Hidalgo, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6154-9983","authenticated-orcid":false,"given":"Nallely","family":"Rivero-Perez","sequence":"additional","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuarias, Universidad Aut\u00f3noma del Estado de Hidalgo, Rancho Universitario Av. Universidad km 1, EX-Hda de Aquetzalpa, Tulancingo 43600, Hidalgo, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0306-3560","authenticated-orcid":false,"given":"Benjam\u00edn","family":"Valladares-Carranza","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Veterinaria y Zootecnia, Universidad Aut\u00f3noma del Estado de M\u00e9xico, El Cerrillo Piedras Blancas, Toluca 50090, Estado de Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Madariaga-Navarrete","sequence":"additional","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Ciencias Agr\u00edcolas y Forestales, Universidad Aut\u00f3noma del Estado de Hidalgo, Instituto de Ciencias Agropecuarias, Rancho Universitario Av. Universidad km 1, EX-Hda de Aquetzalpa, Tulancingo 43600, Hidalgo, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9231-1556","authenticated-orcid":false,"given":"Rosa Isabel","family":"Higuera-Piedrahita","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Superiores Cuautitl\u00e1n, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Carretera Cuautitl\u00e1n-Teoloyucan km 2.5, San Sebasti\u00e1n Xhala, Cuautitl\u00e1n 54714, Estado de Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Delgadillo-Ruiz","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Medicina Veterinaria y Zootecnia, Universidad Aut\u00f3noma de Zacatecas, Kil\u00f3metro 31.5 Carretera Panamerica, Fresnillo 98500, Zacatecas, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3mulo","family":"Ba\u00f1uelos-Valenzuela","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Medicina Veterinaria y Zootecnia, Universidad Aut\u00f3noma de Zacatecas, Kil\u00f3metro 31.5 Carretera Panamerica, Fresnillo 98500, Zacatecas, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8537-5025","authenticated-orcid":false,"given":"Adrian","family":"Zaragoza-Bastida","sequence":"additional","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuarias, Universidad Aut\u00f3noma del Estado de Hidalgo, Rancho Universitario Av. Universidad km 1, EX-Hda de Aquetzalpa, Tulancingo 43600, Hidalgo, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/2395162","article-title":"Flora of Panama: Part VI. Family 88","volume":"56","author":"Woodson","year":"1969","journal-title":"Zygophyllaceae. Ann. Mo. Bot. Gard."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jep.2005.02.002","article-title":"Larrea tridentata (Creosote bush), an abundant plant of Mexican and US-American deserts and its metabolite nordihydroguaiaretic acid","volume":"98","author":"Arteaga","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"ref_3","unstructured":"Integrated Taxonomy Information System (ITIS) (2020, August 21). Larrea tridentata (DC.) 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