{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:21:12Z","timestamp":1791976872012,"version":"4.4.0"},"reference-count":121,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Iron is the most abundant mineral in the human body and plays essential roles in sustaining life, such as the transport of oxygen to systemic organs. The Fenton reaction is the reaction between iron and hydrogen peroxide, generating hydroxyl radical, which is highly reactive and highly toxic to living cells. \u201cFerroptosis\u201d, a programmed cell death in which the Fenton reaction is closely involved, has recently received much attention. Furthermore, various applications of the Fenton reaction have been reported in the medical and nutritional fields, such as cancer treatment or sterilization. Here, this review summarizes the recent growing interest in the usefulness of iron and its biological relevance through basic and practical information of the Fenton reaction and recent reports.<\/jats:p>","DOI":"10.3390\/molecules27175451","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T02:04:32Z","timestamp":1661479472000},"page":"5451","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":143,"title":["Current Use of Fenton Reaction in Drugs and Food"],"prefix":"10.3390","volume":"27","author":[{"given":"Chizumi","family":"Abe","sequence":"first","affiliation":[{"name":"New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai 980-8579, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8937-5110","authenticated-orcid":false,"given":"Taiki","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai 980-8579, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5712-0204","authenticated-orcid":false,"given":"Teruo","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai 980-8579, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3177\/jnsv.68.162","article-title":"Biological Functions of Antioxidant Dipeptides","volume":"68","author":"Ozawa","year":"2022","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1001\/jama.1929.02700420009004","article-title":"The Etiology of Beriberi","volume":"92","author":"Matsumura","year":"1929","journal-title":"J. Am. Med. Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/iub.2008","article-title":"Vitamin E: Regulatory Redox Interactions","volume":"71","author":"Miyazawa","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1046\/j.1365-2141.2003.04529.x","article-title":"Early History of Iron Deficiency","volume":"122","author":"Poskitt","year":"2003","journal-title":"Br. J. Haematol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1039\/D0CS00688B","article-title":"Organic Synthesis with the Most Abundant Transition Metal\u2013Iron: From Rust to Multitasking Catalysts","volume":"50","author":"Rana","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1146\/annurev.genom.1.1.75","article-title":"Iron Metabolism: Iron Deficiency and Iron Overload","volume":"1","author":"Andrews","year":"2000","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"ref_7","first-page":"2","article-title":"Transition Metal Ions at the Crossroads of Mucosal Immunity and Microbial Pathogenesis","volume":"4","author":"Jellbauer","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bbagen.2011.08.002","article-title":"The Long History of Iron in the Universe and in Health and Disease","volume":"1820","author":"Sheftel","year":"2012","journal-title":"Biochim. Biophys. Acta-Gen. Subj."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.3389\/fimmu.2020.01221","article-title":"The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria","volume":"11","author":"Kell","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1242\/jeb.023697","article-title":"The Dual Roles of Red Blood Cells in Tissue Oxygen Delivery: Oxygen Carriers and Regulators of Local Blood Flow","volume":"212","author":"Jensen","year":"2009","journal-title":"J. Exp. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1039\/C7MT00116A","article-title":"The Elemental Role of Iron in DNA Synthesis and Repair","volume":"9","author":"Puig","year":"2017","journal-title":"Metallomics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1039\/CT8946500899","article-title":"LXXIII.\u2014Oxidation of Tartaric Acid in Presence of Iron","volume":"65","author":"Fenton","year":"1894","journal-title":"J. Chem. Soc. Trans."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1021\/acsabm.9b00879","article-title":"Doxorubicin\u2013Metal Coordinated Micellar Nanoparticles for Intracellular Codelivery and Chemo\/Chemodynamic Therapy In Vitro","volume":"2","author":"Ruan","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_14","first-page":"28975","article-title":"Acidity-Triggered Tumor-Targeted Nanosystem for Synergistic Therapy via a Cascade of ROS Generation and NO Release","volume":"12","author":"Cao","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1007\/s12274-021-3758-4","article-title":"BSA Stabilized Photothermal-Fenton Reactor with Cisplatin for Chemo\/Chemodynamic Cascade Oncotherapy","volume":"15","author":"Yang","year":"2022","journal-title":"Nano Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.fct.2017.10.023","article-title":"Current Evidence on the Effect of Dietary Polyphenols Intake on Chronic Diseases","volume":"110","author":"Costa","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1021\/acs.jafc.1c06289","article-title":"Bioactive Peptides: From Basic Research to Clinical Trials and Commercialization","volume":"70","author":"Duffuler","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Ahn-Jarvis, J.H., Parihar, A., and Doseff, A.I. (2019). Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease. Antioxidants, 8.","DOI":"10.3390\/antiox8070202"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ccell.2017.02.018","article-title":"O2\u2212 and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate","volume":"31","author":"Schoenfeld","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0031-9422(91)83011-9","article-title":"Effect of Flavonoids on Hydroxyl Radical Formation by Fenton-Type Reactions; Influence of the Iron Chelator","volume":"31","author":"Puppo","year":"1992","journal-title":"Phytochemistry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"114584","DOI":"10.1016\/j.bcp.2021.114584","article-title":"Recent Progress on Targeting Ferroptosis for Cancer Therapy","volume":"190","author":"Xu","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1002\/cber.19310641118","article-title":"Unpaarigkeit Und Radikalketten Im Reaktionsmechanismus Organischer Und Enzymatischer Vorg\u00e4nge","volume":"64","author":"Haber","year":"1931","journal-title":"Ber. Dtsch. Chem. Ges."},{"key":"ref_23","first-page":"332","article-title":"The Catalytic Decomposition of Hydrogen Peroxide by Iron Salts","volume":"147","author":"Haber","year":"1934","journal-title":"Proc. R. Soc. London. Ser. A Math. Phys. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1039\/D1DT03645A","article-title":"The Principle of Detailed Balancing, the Iron-Catalyzed Disproportionation of Hydrogen Peroxide, and the Fenton Reaction","volume":"51","author":"Stanbury","year":"2022","journal-title":"Dalton Trans."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"22890","DOI":"10.1039\/C8CP04381G","article-title":"A Computational Study of the Fenton Reaction in Different PH Ranges","volume":"20","author":"Lu","year":"2018","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1021\/jp020654p","article-title":"The Fenton Reaction. Dependence of the Rate on PH","volume":"107","author":"Kremer","year":"2003","journal-title":"J. Phys. Chem. A"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"14105","DOI":"10.1021\/acsomega.9b02023","article-title":"Why the Reactive Oxygen Species of the Fenton Reaction Switches from Oxoiron(IV) Species to Hydroxyl Radical in Phosphate Buffer Solutions? A Computational Rationale","volume":"4","author":"Chen","year":"2019","journal-title":"ACS Omega"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1073\/pnas.1314885111","article-title":"Fenton Chemistry at Aqueous Interfaces","volume":"111","author":"Shinichi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.chemosphere.2005.03.052","article-title":"Impact of Radical versus Non-Radical Pathway in the Fenton Chemistry on the Iron Redox Cycle in Clouds","volume":"60","author":"Deguillaume","year":"2005","journal-title":"Chemosphere"},{"key":"ref_30","unstructured":"Prasad, R., Majumdar, K., Shivay, Y., and Kapil, U. (2016). Minerals in Plant and Human Nutrition and Health, International Plant Nutrition Institute (IPNI) Peachtree Corners."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1172\/JCI104747","article-title":"Is Hemoglobin an Essential Structural Component of Human Erythrocyte Membranes?","volume":"42","author":"Weed","year":"1963","journal-title":"J. Clin. Investig."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/bjaceaccp\/mks025","article-title":"Physiology of Haemoglobin","volume":"12","author":"Thomas","year":"2012","journal-title":"Contin. Educ. Anaesth. Crit. Care Pain"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(20)32594-0","article-title":"Iron Deficiency","volume":"397","author":"Pasricha","year":"2021","journal-title":"Lancet"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1017\/S0007114508066762","article-title":"Haem and Folate Transport by Proton-Coupled Folate Transporter\/Haem Carrier Protein 1 (SLC46A1)","volume":"101","author":"Laftah","year":"2008","journal-title":"Br. J. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/41343","article-title":"Cloning and Characterization of a Mammalian Proton-Coupled Metal-Ion Transporter","volume":"388","author":"Gunshin","year":"1997","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cmet.2005.01.003","article-title":"The Iron Exporter Ferroportin\/Slc40a1 Is Essential for Iron Homeostasis","volume":"1","author":"Donovan","year":"2005","journal-title":"Cell Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41586-020-2668-z","article-title":"Structure of Hepcidin-Bound Ferroportin Reveals Iron Homeostatic Mechanisms","volume":"586","author":"Azumaya","year":"2020","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1182\/blood-2018-05-815944","article-title":"Iron Deficiency","volume":"133","author":"Camaschella","year":"2019","journal-title":"Blood"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Yiannikourides, A., and Latunde-Dada, G.O. (2019). A Short Review of Iron Metabolism and Pathophysiology of Iron Disorders. Medicines, 6.","DOI":"10.3390\/medicines6030085"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Lesjak, M., and Srai, S.K.S. (2019). Role of Dietary Flavonoids in Iron Homeostasis. Pharmaceuticals, 12.","DOI":"10.3390\/ph12030119"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Lesjak, M., Hoque, R., Balesaria, S., Skinner, V., Debnam, E.S., Srai, S.K.S., and Sharp, P.A. (2014). Quercetin Inhibits Intestinal Iron Absorption and Ferroportin Transporter Expression In Vivo and In Vitro. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102900"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1093\/jn\/nxab159","article-title":"Tea Consumption Reduces Iron Bioavailability from NaFeEDTA in Nonanemic Women and Women with Iron Deficiency Anemia: Stable Iron Isotope Studies in Morocco","volume":"151","author":"Lazrak","year":"2021","journal-title":"J. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tifs.2020.02.021","article-title":"Iron Deficiency Anemia: A Comprehensive Review on Iron Absorption, Bioavailability and Emerging Food Fortification Approaches","volume":"99","author":"Shubham","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.jnutbio.2011.10.013","article-title":"High-Fat Diet Causes Iron Deficiency via Hepcidin-Independent Reduction of Duodenal Iron Absorption","volume":"23","author":"Sonnweber","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.3945\/ajcn.114.099218","article-title":"In Overweight and Obese Women, Dietary Iron Absorption Is Reduced and the Enhancement of Iron Absorption by Ascorbic Acid Is One-Half That in Normal-Weight Women","volume":"102","author":"Zimmermann","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Villa\u00f1o, D., Vilaplana, C., Medina, S., Algaba-Chueca, F., Cejuela-Anta, R., Mart\u00ednez-Sanz, J.M., Ferreres, F., and Gil-Izquierdo, A. (2016). Relationship between the Ingestion of a Polyphenol-Rich Drink, Hepcidin Hormone, and Long-Term Training. Molecules, 21.","DOI":"10.3390\/molecules21101333"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jnutbio.2015.10.015","article-title":"The Dietary Flavonoid Myricetin Regulates Iron Homeostasis by Suppressing Hepcidin Expression","volume":"30","author":"Mu","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2215\/CJN.05931108","article-title":"Hepcidin\u2014A Potential Novel Biomarker for Iron Status in Chronic Kidney Disease","volume":"4","author":"Zaritsky","year":"2009","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1210\/en.2011-2045","article-title":"17\u03b2-Estradiol Inhibits Iron Hormone Hepcidin Through an Estrogen Responsive Element Half-Site","volume":"153","author":"Yang","year":"2012","journal-title":"Endocrinology"},{"key":"ref_50","first-page":"24","article-title":"Factors Affecting Iron Absorption and Mitigation Mechanisms: A Review","volume":"4","author":"Dasa","year":"2018","journal-title":"Int. J. Agric. Sci. Food Technol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.freeradbiomed.2016.04.198","article-title":"Mitochondrial ROS Regulation of Proliferating Cells","volume":"100","author":"Diebold","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1093\/jxb\/ery168","article-title":"ROS and Redox Balance as Multifaceted Players of Cross-Tolerance: Epigenetic and Retrograde Control of Gene Expression","volume":"69","author":"Locato","year":"2018","journal-title":"J. Exp. Bot."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1073\/pnas.0400265101","article-title":"A Fenton Reaction at the Endoplasmic Reticulum Is Involved in the Redox Control of Hypoxia-Inducible Gene Expression","volume":"101","author":"Qing","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6344","DOI":"10.1039\/D0CC00233J","article-title":"An Endoplasmic Reticulum-Targeting Fluorescent Probe for Imaging \u02d9OH in Living Cells","volume":"56","author":"Zhao","year":"2020","journal-title":"Chem. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.emboj.7601974","article-title":"Protein Quality Control in the Early Secretory Pathway","volume":"27","author":"Anelli","year":"2008","journal-title":"EMBO J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1002\/asia.201400099","article-title":"Effect of Various Intercalators on the Fenton-Type Oxidative Cleavage of Double-Stranded DNA","volume":"9","author":"Kim","year":"2014","journal-title":"Chem. Asian J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.2834821","article-title":"Toxic DNA Damage by Hydrogen Peroxide Through the Fenton Reaction in Vivo and in Vitro","volume":"240","author":"Imlay","year":"1988","journal-title":"Science"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-5793(86)80626-3","article-title":"Iron Promoters of the Fenton Reaction and Lipid Peroxidation Can Be Released from Haemoglobin by Peroxides","volume":"201","author":"Gutteridge","year":"1986","journal-title":"FEBS Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2183\/pjab.97.010","article-title":"Lipid Hydroperoxides in Nutrition, Health, and Diseases","volume":"97","author":"Miyazawa","year":"2021","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"12691","DOI":"10.1073\/pnas.202312699","article-title":"Protein Nitration Is Mediated by Heme and Free Metals through Fenton-Type Chemistry: An Alternative to the NO\/O2\u2212 Reaction","volume":"99","author":"Thomas","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"654207","DOI":"10.4061\/2011\/654207","article-title":"Formation of the 42-Mer and Amyloid \u03b2 Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer\u2019s Disease","volume":"2011","author":"Murakami","year":"2011","journal-title":"J. Amino Acids"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2183\/pjab.60.345","article-title":"Resonance Raman Evidence for the Presence of the FeIV=O Bond in Horseradish Peroxidase Compound II","volume":"60","author":"Hachimoto","year":"1984","journal-title":"Proc. Jpn. Acad. Ser. B"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"SCI-20","DOI":"10.1182\/blood.V128.22.SCI-20.SCI-20","article-title":"Ferritinophagy and Cell Cycle Control","volume":"128","author":"Carlomagno","year":"2016","journal-title":"Blood"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"723801","DOI":"10.3389\/fcell.2021.723801","article-title":"Iron-Dependent Autophagic Cell Death Induced by Radiation in MDA-MB-231 Breast Cancer Cells","volume":"9","author":"Ma","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","article-title":"Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells","volume":"15","author":"Yang","year":"2008","journal-title":"Chem. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41419-019-2064-5","article-title":"ROS-Mediated Autophagy Increases Intracellular Iron Levels and Ferroptosis by Ferritin and Transferrin Receptor Regulation","volume":"10","author":"Park","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: Process and Function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: Machinery and Regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Bebber, C.M., M\u00fcller, F., Prieto Clemente, L., Weber, J., and von Karstedt, S. (2020). Ferroptosis in Cancer Cell Biology. Cancers, 12.","DOI":"10.3390\/cancers12010164"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/jcp.54.3.176","article-title":"Antioxidants in Health and Disease","volume":"54","author":"Young","year":"2001","journal-title":"J. Clin. Pathol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"100864","DOI":"10.1016\/j.apmt.2020.100864","article-title":"Fenton Reaction-Based Nanomedicine in Cancer Chemodynamic and Synergistic Therapy","volume":"21","author":"Meng","year":"2020","journal-title":"Appl. Mater. Today"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"11819","DOI":"10.1021\/acsnano.8b07635","article-title":"Cancer Treatment through Nanoparticle-Facilitated Fenton Reaction","volume":"12","author":"Gurr","year":"2018","journal-title":"ACS Nano"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.2147\/IJN.S298606","article-title":"A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology","volume":"16","author":"Miyazawa","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jconrel.2021.09.019","article-title":"Photothermal Nanozyme-Ignited Fenton Reaction-Independent Ferroptosis for Breast Cancer Therapy","volume":"339","author":"Xing","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.7150\/thno.41882","article-title":"Ellagic Acid-Fe@BSA Nanoparticles for Endogenous H2S Accelerated Fe(III)\/Fe(II) Conversion and Photothermal Synergistically Enhanced Chemodynamic Therapy","volume":"10","author":"Tian","year":"2020","journal-title":"Theranostics"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1021\/jacs.9b12873","article-title":"Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy","volume":"142","author":"Sang","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1039\/C9NJ05860E","article-title":"Mitochondria-Targeted Delivery and Light Controlled Release of Iron Prodrug and CO to Enhance Cancer Therapy by Ferroptosis","volume":"44","author":"Gao","year":"2020","journal-title":"New J. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1021\/acs.molpharmaceut.9b00819","article-title":"Enhanced Reactive Oxygen Species Levels by an Active Benzothiazole Complex-Mediated Fenton Reaction for Highly Effective Antitumor Therapy","volume":"16","author":"You","year":"2019","journal-title":"Mol. Pharm."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"10142","DOI":"10.1021\/acsami.0c00170","article-title":"Hollow Porous Carbon Coated FeS2-Based Nanocatalysts for Multimodal Imaging-Guided Photothermal, Starvation, and Triple-Enhanced Chemodynamic Therapy of Cancer","volume":"12","author":"Wu","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"101353","DOI":"10.1016\/j.apmt.2021.101353","article-title":"Targeted Delivery of Fenton Reaction Packages and Drugs for Cancer Theranostics","volume":"26","author":"Fu","year":"2022","journal-title":"Appl. Mater. Today"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"30551","DOI":"10.1021\/acsami.9b09323","article-title":"Tumor-Specific Expansion of Oxidative Stress by Glutathione Depletion and Use of a Fenton Nanoagent for Enhanced Chemodynamic Therapy","volume":"11","author":"Chen","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Sun, F., Peng, Y., Li, Y., Xu, M., and Cai, T. (2022). Fenton-Reaction-Triggered Metabolism of Acetaminophen for Enhanced Cancer Therapy. Chin. Chem. Lett., in press.","DOI":"10.1016\/j.cclet.2022.05.021"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"121810","DOI":"10.1016\/j.ijpharm.2022.121810","article-title":"Mitochondrial Targeted Drug Delivery Combined with Manganese Catalyzed Fenton Reaction for the Treatment of Breast Cancer","volume":"622","author":"Zhong","year":"2022","journal-title":"Int. J. Pharm."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1039\/D0TB00008F","article-title":"A Metal\u2013Phenolic Network-Based Multifunctional Nanocomposite with PH-Responsive ROS Generation and Drug Release for Synergistic Chemodynamic\/Photothermal\/Chemo-Therapy","volume":"8","author":"Meng","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"111750","DOI":"10.1016\/j.colsurfb.2021.111750","article-title":"A PH-Sensitive Drug Delivery System Based on Hyaluronic Acid Co-Deliver Doxorubicin and Aminoferrocene for the Combined Application of Chemotherapy and Chemodynamic Therapy","volume":"203","author":"Lei","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"121898","DOI":"10.1016\/j.ijpharm.2022.121898","article-title":"Dual-Responsive Multifunctional \u201cCore\u2013Shell\u201d Magnetic Nanoparticles Promoting Fenton Reaction for Tumor Ferroptosis Therapy","volume":"622","author":"Chi","year":"2022","journal-title":"Int. J. Pharm."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1021\/acsami.1c14135","article-title":"Dual-Responsive and ROS-Augmented Nanoplatform for Chemo\/Photodynamic\/Chemodynamic Combination Therapy of Triple Negative Breast Cancer","volume":"14","author":"Chen","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"567652","DOI":"10.3389\/fchem.2020.567652","article-title":"Magnetic Silica Nanosystems With NIR-Responsive and Redox Reaction Capacity for Drug Delivery and Tumor Therapy","volume":"8","author":"Jia","year":"2020","journal-title":"Front. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1021\/acsanm.9b02405","article-title":"Pharmacologic Vitamin C-Based Cell Therapy via Iron Oxide Nanoparticle-Induced Intracellular Fenton Reaction","volume":"3","author":"Pal","year":"2020","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bbrc.2021.02.126","article-title":"Vitamin C Induces Ferroptosis in Anaplastic Thyroid Cancer Cells by Ferritinophagy Activation","volume":"551","author":"Wang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.cej.2019.02.078","article-title":"Tea Polyphenols Promote Fenton-like Reaction: PH Self-Driving Chelation and Reduction Mechanism","volume":"366","author":"Ouyang","year":"2019","journal-title":"Chem. Eng. J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"12246","DOI":"10.1039\/D0CC03607B","article-title":"Therapeutic Iminoboronate-Based Polymersomes with a Cu(II)-Mediated Fenton Reaction-Enhanced ROS-Response","volume":"56","author":"Cheng","year":"2020","journal-title":"Chem. Commun."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1906128","DOI":"10.1002\/adfm.201906128","article-title":"Boosting H2O2-Guided Chemodynamic Therapy of Cancer by Enhancing Reaction Kinetics through Versatile Biomimetic Fenton Nanocatalysts and the Second Near-Infrared Light Irradiation","volume":"30","author":"Wang","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"10559","DOI":"10.1039\/D0TB01794A","article-title":"A Porous Material Excited by Near-Infrared Light for Photo\/Chemodynamic and Photothermal Dual-Mode Combination Therapy","volume":"8","author":"Sun","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"111635","DOI":"10.1016\/j.jinorgbio.2021.111635","article-title":"The Effect of Luteolin on DNA Damage Mediated by a Copper Catalyzed Fenton Reaction","volume":"226","author":"Jomova","year":"2022","journal-title":"J. Inorg. Biochem."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Simunkova, M., Barbierikova, Z., Jomova, K., Hudecova, L., Lauro, P., Alwasel, S.H., Alhazza, I., Rhodes, C.J., and Valko, M. (2021). Antioxidant vs. Prooxidant Properties of the Flavonoid, Kaempferol, in the Presence of Cu(II) Ions: A ROS-Scavenging Activity, Fenton Reaction and DNA Damage Study. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041619"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"9982","DOI":"10.1039\/c0dt00752h","article-title":"Kinetics of Iron Oxidation upon Polyphenol Binding","volume":"39","author":"Perron","year":"2010","journal-title":"Dalt. Trans."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free Radicals and Antioxidants in Normal Physiological Functions and Human Disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/10715760290019291","article-title":"Lysozyme Modification by the Fenton Reaction and Gamma Radiation","volume":"36","author":"Edwards","year":"2002","journal-title":"Free Radic. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s10753-016-0360-0","article-title":"Fenton Reaction-Generated Advanced Oxidation Protein Products Induces Inflammation in Human Embryonic Kidney Cells","volume":"39","author":"Bochi","year":"2016","journal-title":"Inflammation"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1271\/bbb.68.1324","article-title":"Egg Yolk Phosvitin Inhibits Hydroxyl Radical Formation from the Fenton Reaction","volume":"68","author":"Ishikawa","year":"2004","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Voltea, S., Karabagias, I.K., and Roussis, I.G. (2022). Use of Fe (II) and H2O2 along with Heating for the Estimation of the Browning Susceptibility of White Wine. Appl. Sci., 12.","DOI":"10.3390\/app12094422"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1080\/01919512.2017.1345617","article-title":"Better Lime Purification of Raw Sugar Beet Juice by Advanced Fenton Oxidation Process","volume":"40","author":"Keramat","year":"2018","journal-title":"Ozone Sci. Eng."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1021\/jf011329m","article-title":"Degradation of the Coffee Flavor Compound Furfuryl Mercaptan in Model Fenton-Type Reaction Systems","volume":"50","author":"Blank","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"106779","DOI":"10.1016\/j.foodhyd.2021.106779","article-title":"Structural, Antioxidant, Prebiotic and Anti-Inflammatory Properties of Pectic Oligosaccharides Hydrolyzed from Okra Pectin by Fenton Reaction","volume":"118","author":"Yeung","year":"2021","journal-title":"Food Hydrocoll."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"110847","DOI":"10.1016\/j.foodres.2021.110847","article-title":"Fenton Reaction-Assisted Photodynamic Inactivation of Calcined Melamine Sponge against Salmonella and Its Application","volume":"151","author":"Shi","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1515\/gps-2013-0113","article-title":"A New Green Approach to Fenton\u2019s Chemistry Using Tea Dregs and Coffee Grounds as Raw Material","volume":"3","author":"Morikawa","year":"2014","journal-title":"Green Process. Synth."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ijantimicag.2010.11.034","article-title":"The Ferritin-like Protein Dps Protects Salmonella Enterica Serotype Enteritidis from the Fenton-Mediated Killing Mechanism of Bactericidal Antibiotics","volume":"37","author":"Calhoun","year":"2011","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.foodchem.2009.10.024","article-title":"Fluorometric Determination of Hydrogen Peroxide in Milk by Using a Fenton Reaction System","volume":"120","author":"Abbas","year":"2010","journal-title":"Food Chem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"7826","DOI":"10.3168\/jds.2020-18256","article-title":"Dual-Mode Immunoassay System Based on Glucose Oxidase-Triggered Fenton Reaction for Qualitative and Quantitative Detection of Danofloxacin in Milk","volume":"103","author":"Wang","year":"2020","journal-title":"J. Dairy Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1021\/acssuschemeng.7b04191","article-title":"Fenton Reaction-Oxidized Bamboo Lignin Surface and Structural Modification to Reduce Nonproductive Cellulase Binding and Improve Enzyme Digestion of Cellulose","volume":"6","author":"Wu","year":"2018","journal-title":"ACS Sustain. Chem. Eng."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.biortech.2016.05.032","article-title":"Enhancing Enzymolysis and Fermentation Efficiency of Sugarcane Bagasse by Synergistic Pretreatment of Fenton Reaction and Sodium Hydroxide Extraction","volume":"214","author":"Zhang","year":"2016","journal-title":"Bioresour. Technol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"127558","DOI":"10.1016\/j.chemosphere.2020.127558","article-title":"Efficient Degradation of Chloroquine Drug by Electro-Fenton Oxidation: Effects of Operating Conditions and Degradation Mechanism","volume":"260","author":"Midassi","year":"2020","journal-title":"Chemosphere"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"101171","DOI":"10.1016\/j.jwpe.2020.101171","article-title":"Degradation of NSAIDs by Optimized Photo-Fenton Process Using UV-LEDs at near-Neutral PH","volume":"35","author":"Marchetti","year":"2020","journal-title":"J. Water Process Eng."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jelechem.2014.03.027","article-title":"Electro-Fenton Degradation of the Food Dye Amaranth Using a Gas Diffusion Electrode Modified with Cobalt (II) Phthalocyanine","volume":"722\u2013723","author":"Barros","year":"2014","journal-title":"J. Electroanal. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"129943","DOI":"10.1016\/j.cej.2021.129943","article-title":"Fenton Oxidation of Synthetic Food Dyes by Fe-Embedded Coffee Biochar Catalysts Prepared at Different Pyrolysis Temperatures: A Mechanism Study","volume":"421","author":"Shin","year":"2021","journal-title":"Chem. Eng. J."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"11105","DOI":"10.1073\/pnas.0804226105","article-title":"Pharmacologic Doses of Ascorbate Act as a Prooxidant and Decrease Growth of Aggressive Tumor Xenografts in Mice","volume":"105","author":"Chen","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41568-019-0135-7","article-title":"Targeting Cancer Vulnerabilities with High-Dose Vitamin C","volume":"19","author":"Ngo","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1126\/science.aaa5004","article-title":"Vitamin C Selectively Kills KRAS and BRAF Mutant Colorectal Cancer Cells by Targeting GAPDH","volume":"350","author":"Yun","year":"2015","journal-title":"Science"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1039\/D1AN02160E","article-title":"Determination of Intracellular Ascorbic Acid Using Tandem Mass Spectrometry","volume":"147","author":"Abe","year":"2022","journal-title":"Analyst"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/17\/5451\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:15:20Z","timestamp":1760141720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/17\/5451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,25]]},"references-count":121,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["molecules27175451"],"URL":"https:\/\/doi.org\/10.3390\/molecules27175451","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,25]]}}}