{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T04:52:28Z","timestamp":1783227148169,"version":"3.54.6"},"reference-count":25,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Project of Liaoning Education Department","award":["LJKZ0645"],"award-info":[{"award-number":["LJKZ0645"]}]},{"name":"Scientific Research Project of Liaoning Education Department","award":["32172454"],"award-info":[{"award-number":["32172454"]}]},{"name":"Scientific Research Project of Liaoning Education Department","award":["2019JH2\/10200012"],"award-info":[{"award-number":["2019JH2\/10200012"]}]},{"name":"National Natural Science Foundation of China","award":["LJKZ0645"],"award-info":[{"award-number":["LJKZ0645"]}]},{"name":"National Natural Science Foundation of China","award":["32172454"],"award-info":[{"award-number":["32172454"]}]},{"name":"National Natural Science Foundation of China","award":["2019JH2\/10200012"],"award-info":[{"award-number":["2019JH2\/10200012"]}]},{"name":"Hightech R&amp;D Program of Liaoning","award":["LJKZ0645"],"award-info":[{"award-number":["LJKZ0645"]}]},{"name":"Hightech R&amp;D Program of Liaoning","award":["32172454"],"award-info":[{"award-number":["32172454"]}]},{"name":"Hightech R&amp;D Program of Liaoning","award":["2019JH2\/10200012"],"award-info":[{"award-number":["2019JH2\/10200012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>To develop new fungicides with high efficiency, 46 novel sulfonamide derivatives were designed and synthesized by introducing pinacolone fragment into chesulfamide which was used as lead compound. All compounds were characterized by 1H NMR, 13C NMR, and MS spectra, and the structure of compound P-27 was also confirmed by X-ray single crystal diffraction. It was found that a variety of compounds present excellent inhibitory effect against Botrytis cinerea. The inhibition rates of P-29 on tomato and strawberry were 90.24% (200 mg\/L) and 100% (400 mg\/L) in vivo respectively, which were better than the lead compound chesulfamide (59.23% on tomato seedlings and 29.63% on strawberries).<\/jats:p>","DOI":"10.3390\/molecules27175468","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T02:04:32Z","timestamp":1661479472000},"page":"5468","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Design, Synthesis and Structure-Activity Relationship of Novel Pinacolone Sulfonamide Derivatives against Botrytis cinerea as Potent Antifungal Agents"],"prefix":"10.3390","volume":"27","author":[{"given":"Chaojie","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiu","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6536-752X","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1094\/PHYTO-10-20-0475-IA","article-title":"Botrytis spp.: A contemporary perspective and synthesis of recent scientific developments of a widespread genus that threatens global food security","volume":"111","author":"Richards","year":"2021","journal-title":"Phytopathology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1126\/science.aar3780","article-title":"Wicked evolution: Can we address the 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Lett."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/17\/5468\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:15:33Z","timestamp":1760141733000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/17\/5468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,25]]},"references-count":25,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["molecules27175468"],"URL":"https:\/\/doi.org\/10.3390\/molecules27175468","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,25]]}}}