{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:43:33Z","timestamp":1790808213029,"version":"4.1.0"},"reference-count":76,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research, Development and Innovation Fund of Hungary","award":["TKP2021-EGA-18"],"award-info":[{"award-number":["TKP2021-EGA-18"]}]},{"name":"National Research, Development and Innovation Fund of Hungary","award":["TKP2021-EGA"],"award-info":[{"award-number":["TKP2021-EGA"]}]},{"name":"National Research, Development and Innovation Fund of Hungary","award":["EFOP-3.6.1-16-2016-0002"],"award-info":[{"award-number":["EFOP-3.6.1-16-2016-0002"]}]},{"name":"National Research, Development and Innovation Fund of Hungary","award":["GINOP-2.3.4-15-2020-00008"],"award-info":[{"award-number":["GINOP-2.3.4-15-2020-00008"]}]},{"name":"Debrecen Venture Table S Catapult","award":["TKP2021-EGA-18"],"award-info":[{"award-number":["TKP2021-EGA-18"]}]},{"name":"Debrecen Venture Table S Catapult","award":["TKP2021-EGA"],"award-info":[{"award-number":["TKP2021-EGA"]}]},{"name":"Debrecen Venture Table S Catapult","award":["EFOP-3.6.1-16-2016-0002"],"award-info":[{"award-number":["EFOP-3.6.1-16-2016-0002"]}]},{"name":"Debrecen Venture Table S Catapult","award":["GINOP-2.3.4-15-2020-00008"],"award-info":[{"award-number":["GINOP-2.3.4-15-2020-00008"]}]},{"name":"European Union","award":["TKP2021-EGA-18"],"award-info":[{"award-number":["TKP2021-EGA-18"]}]},{"name":"European Union","award":["TKP2021-EGA"],"award-info":[{"award-number":["TKP2021-EGA"]}]},{"name":"European Union","award":["EFOP-3.6.1-16-2016-0002"],"award-info":[{"award-number":["EFOP-3.6.1-16-2016-0002"]}]},{"name":"European Union","award":["GINOP-2.3.4-15-2020-00008"],"award-info":[{"award-number":["GINOP-2.3.4-15-2020-00008"]}]},{"name":"Ministry of Hungary Domus Hungarica 2019","award":["TKP2021-EGA-18"],"award-info":[{"award-number":["TKP2021-EGA-18"]}]},{"name":"Ministry of Hungary Domus Hungarica 2019","award":["TKP2021-EGA"],"award-info":[{"award-number":["TKP2021-EGA"]}]},{"name":"Ministry of Hungary Domus Hungarica 2019","award":["EFOP-3.6.1-16-2016-0002"],"award-info":[{"award-number":["EFOP-3.6.1-16-2016-0002"]}]},{"name":"Ministry of Hungary Domus Hungarica 2019","award":["GINOP-2.3.4-15-2020-00008"],"award-info":[{"award-number":["GINOP-2.3.4-15-2020-00008"]}]},{"name":"Richter Gedeon Talent Foundation","award":["TKP2021-EGA-18"],"award-info":[{"award-number":["TKP2021-EGA-18"]}]},{"name":"Richter Gedeon Talent Foundation","award":["TKP2021-EGA"],"award-info":[{"award-number":["TKP2021-EGA"]}]},{"name":"Richter Gedeon Talent Foundation","award":["EFOP-3.6.1-16-2016-0002"],"award-info":[{"award-number":["EFOP-3.6.1-16-2016-0002"]}]},{"name":"Richter Gedeon Talent Foundation","award":["GINOP-2.3.4-15-2020-00008"],"award-info":[{"award-number":["GINOP-2.3.4-15-2020-00008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The aim of this study was to evaluate the phytochemical profile and antioxidant properties of the extracts from three Rosa species (R. canina, R. damascena, R. cairo), to develop and investigate topical formulations with lyophilized forms of extracts for the treatment of psoriasis. Phytochemical screening and in vitro total antioxidant capacity (DPPH, FRAP, CUPRAC, SOD) of studied samples were examined and compared. Lyophilized extracts of roses were dissolved in Transcutol HP and different formulations of creams were prepared. Franz diffusion method was used to evaluate the drug release and biocompatibility was tested on HaCaT cells. Rosa damascene had the best results regarding all the analyses that were conducted. After the evaluation of topical products, the formulation with Rosa damascena extract in a self-emulsifying drug delivery system was tested on a human clinical study that involved 20 patients. At the end of the clinical study an improvement in the quality of life of the patients was observed and erythema, induration and scaling were reduced. The present study indicates that our examined extracts exhibited great phenolic content, antioxidant capacity and safety profile of topical formulation and therefore can be used as a reliable source of natural antioxidants and may be used as a complementary treatment to improve the quality life of patients with psoriasis or may be tested on another diseases.<\/jats:p>","DOI":"10.3390\/molecules27175499","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T03:34:56Z","timestamp":1661744096000},"page":"5499","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["In Vitro and Human Pilot Studies of Different Topical Formulations Containing Rosa Species for the Treatment of Psoriasis"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7226-5062","authenticated-orcid":false,"given":"Diana Ioana","family":"Gavra","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, H-410028 Oradea, Romania"},{"name":"Doctoral School of Biomedical Sciences, University of Oradea, H-410073 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3315-2364","authenticated-orcid":false,"given":"Laura","family":"Endres","sequence":"additional","affiliation":[{"name":"Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, H-410073 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gota","family":"Pet\u0151","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei K\u00f6r\u00fat 98, H-4032 Debrecen, Hungary"},{"name":"Doctoral School of Pharmaceutical Sciences, University of Debrecen, Nagyerdei K\u00f6r\u00fat 98, H-4032 Debrecen, Hungary"},{"name":"Institute of Healthcare Industry, University of Debrecen, Nagyerdei K\u00f6r\u00fat 98, H-4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5835-5304","authenticated-orcid":false,"given":"Liza","family":"J\u00f3zsa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei K\u00f6r\u00fat 98, H-4032 Debrecen, Hungary"},{"name":"Doctoral School of Pharmaceutical Sciences, University of Debrecen, Nagyerdei K\u00f6r\u00fat 98, H-4032 Debrecen, Hungary"},{"name":"Institute of Healthcare Industry, University of Debrecen, Nagyerdei K\u00f6r\u00fat 98, H-4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e1lma","family":"Feh\u00e9r","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei K\u00f6r\u00fat 98, H-4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9724-0614","authenticated-orcid":false,"given":"Zolt\u00e1n","family":"Ujhelyi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei K\u00f6r\u00fat 98, H-4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7146-3040","authenticated-orcid":false,"given":"Annam\u00e1ria","family":"Pallag","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, H-410028 Oradea, Romania"},{"name":"Doctoral School of Biomedical Sciences, University of Oradea, H-410073 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-1590","authenticated-orcid":false,"given":"Eleonora","family":"Marian","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, H-410028 Oradea, Romania"},{"name":"Doctoral School of Biomedical Sciences, University of Oradea, H-410073 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5328-333X","authenticated-orcid":false,"given":"Laura Gratiela","family":"Vicas","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, H-410028 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8981-1958","authenticated-orcid":false,"given":"Timea 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