{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:39:57Z","timestamp":1792805997411,"version":"4.5.0"},"reference-count":184,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Apoio \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco (FACEPE)","award":["APQ 0378-3.06\/14"],"award-info":[{"award-number":["APQ 0378-3.06\/14"]}]},{"name":"Funda\u00e7\u00e3o de Apoio \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco (FACEPE)","award":["405026\/2018-8"],"award-info":[{"award-number":["405026\/2018-8"]}]},{"name":"Funda\u00e7\u00e3o de Apoio \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco (FACEPE)","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["APQ 0378-3.06\/14"],"award-info":[{"award-number":["APQ 0378-3.06\/14"]}],"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["405026\/2018-8"],"award-info":[{"award-number":["405026\/2018-8"]}],"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","award":["APQ 0378-3.06\/14"],"award-info":[{"award-number":["APQ 0378-3.06\/14"]}],"id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","award":["405026\/2018-8"],"award-info":[{"award-number":["405026\/2018-8"]}],"id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Chronic ulcers are among the main causes of morbidity and mortality due to the high probability of infection and sepsis and therefore exert a significant impact on public health resources. Numerous types of dressings are used for the treatment of skin ulcers-each with different advantages and disadvantages. Bacterial cellulose (BC) has received enormous interest in the cosmetic, pharmaceutical, and medical fields due to its biological, physical, and mechanical characteristics, which enable the creation of polymer composites and blends with broad applications. In the medical field, BC was at first used in wound dressings, tissue regeneration, and artificial blood vessels. This material is suitable for treating various skin diseases due its considerable fluid retention and medication loading properties. BC membranes are used as a temporary dressing for skin treatments due to their excellent fit to the body, reduction in pain, and acceleration of epithelial regeneration. BC-based composites and blends have been evaluated and synthesized both in vitro and in vivo to create an ideal microenvironment for wound healing. This review describes different methods of producing and handling BC for use in the medical field and highlights the qualities of BC in detail with emphasis on biomedical reports that demonstrate its utility. Moreover, it gives an account of biomedical applications, especially for tissue engineering and wound dressing materials reported until date. This review also includes patents of BC applied as a wound dressing material.<\/jats:p>","DOI":"10.3390\/molecules27175580","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:13:56Z","timestamp":1661904836000},"page":"5580","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Bacterial Cellulose as a Versatile Biomaterial for Wound Dressing Application"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4518-5729","authenticated-orcid":false,"given":"Julia Didier Pedrosa","family":"de Amorim","sequence":"first","affiliation":[{"name":"Rede Nordeste de Biotecnologia (RENORBIO), Universidade Federal Rural de Pernambuco (UFRPE), Rua Dom Manuel de Medeiros, Dois Irm\u00e3os, Recife CEP 52171-900, Brazil"},{"name":"Instituto Avan\u00e7ado de Tecnologia e Inova\u00e7\u00e3o (IATI), Rua Potyra, n. 31, Prado, Recife CEP 50751-310, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Jos\u00e9 Galdino","family":"da Silva Junior","sequence":"additional","affiliation":[{"name":"Rede Nordeste de Biotecnologia (RENORBIO), Universidade Federal Rural de Pernambuco (UFRPE), Rua Dom Manuel de Medeiros, Dois Irm\u00e3os, Recife CEP 52171-900, Brazil"},{"name":"Instituto Avan\u00e7ado de Tecnologia e Inova\u00e7\u00e3o (IATI), Rua Potyra, n. 31, Prado, Recife CEP 50751-310, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre D\u2019Lamare Maia","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Rede Nordeste de Biotecnologia (RENORBIO), Universidade Federal Rural de Pernambuco (UFRPE), Rua Dom Manuel de Medeiros, Dois Irm\u00e3os, Recife CEP 52171-900, Brazil"},{"name":"Instituto Avan\u00e7ado de Tecnologia e Inova\u00e7\u00e3o (IATI), Rua Potyra, n. 31, Prado, Recife CEP 50751-310, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helenise Almeida","family":"do Nascimento","sequence":"additional","affiliation":[{"name":"Centro de Tecnologia e Geoci\u00eancias, Departamento de Engenharia Qu\u00edmica, Universidade Federal de Pernambuco (UFPE), Cidade Universit\u00e1ria, s\/n, Recife CEP 50740-540, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Sarubbo","sequence":"additional","affiliation":[{"name":"Instituto Avan\u00e7ado de Tecnologia e Inova\u00e7\u00e3o (IATI), Rua Potyra, n. 31, Prado, Recife CEP 50751-310, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6628-9033","authenticated-orcid":false,"given":"Thiago Pettrus Maia","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Brasileiro (UNIBRA), Rua Padre Ingl\u00eas, 257, R. Padre Ingl\u00eas, 356-Boa Vista, Recife CEP 50050-230, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a Fernanda de Santana","family":"Costa","sequence":"additional","affiliation":[{"name":"Instituto Avan\u00e7ado de Tecnologia e Inova\u00e7\u00e3o (IATI), Rua Potyra, n. 31, Prado, Recife CEP 50751-310, Brazil"},{"name":"Centro de Comunica\u00e7\u00e3o e Design, Centro Acad\u00eamico da Regi\u00e3o Agreste, Universidade Federal de Pernambuco (UFPE), BR 104, Km 59, s\/n, Nova Caruaru, Caruaru CEP 50670-90, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4746-0560","authenticated-orcid":false,"given":"Leonie Asfora","family":"Sarubbo","sequence":"additional","affiliation":[{"name":"Rede Nordeste de Biotecnologia (RENORBIO), Universidade Federal Rural de Pernambuco (UFRPE), Rua Dom Manuel de Medeiros, Dois Irm\u00e3os, Recife CEP 52171-900, Brazil"},{"name":"Instituto Avan\u00e7ado de Tecnologia e Inova\u00e7\u00e3o (IATI), Rua Potyra, n. 31, Prado, Recife CEP 50751-310, Brazil"},{"name":"Escola Icam Tech, Universidade Cat\u00f3lica de Pernambuco (UNICAP), Rua do Pr\u00edncipe, n. 526, Boa Vista, Recife CEP 50050-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1002\/anie.201001273","article-title":"Nanocelluloses: A new family of nature-based materials","volume":"50","author":"Klemm","year":"2011","journal-title":"Angew. 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