{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:14:57Z","timestamp":1792289697654,"version":"4.4.0"},"reference-count":137,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Wounds are structural and functional disruptions of skin that occur because of trauma, surgery, acute illness, or chronic disease conditions. Chronic wounds are caused by a breakdown in the finely coordinated cascade of events that occurs during healing. Wound healing is a long process that split into at least three continuous and overlapping processes: an inflammatory response, a proliferative phase, and finally the tissue remodeling. Therefore, these processes are extensively studied to develop novel therapeutics in order to achieve maximum recovery with minimum scarring. Several growth hormones and cytokines secreted at the site of lesions tightly regulates the healing processes. The traditional approach for wound management has been represented by topical treatments. Metal nanoparticles (e.g., silver, gold and zinc) are increasingly being employed in dermatology due to their favorable effects on healing, as well as in treating and preventing secondary bacterial infections. In the current review, a brief introduction on traditional would healing approach is provided, followed by focus on the potential of wound dressing therapeutic techniques functionalized with Ag-NPs.<\/jats:p>","DOI":"10.3390\/molecules27175587","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:13:56Z","timestamp":1661904836000},"page":"5587","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Silver Nanoparticles and Its Mechanistic Insight for Chronic Wound Healing: Review on Recent Progress"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1727-0870","authenticated-orcid":false,"given":"Manoj","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana 133207, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanita","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana 133207, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6044-3239","authenticated-orcid":false,"given":"Vikas","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana 133207, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana 133207, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana 133207, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana 133207, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil Kumar","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana 133207, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00e9ta","family":"Macho","sequence":"additional","affiliation":[{"name":"Laboratory of Algal Biotechnology-Centre Algatech, Institute of Microbiology of the Czech Academy of Sciences, 37901 T\u0159ebo\u0148, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avik","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Laboratory of Algal Biotechnology-Centre Algatech, Institute of Microbiology of the Czech Academy of Sciences, 37901 T\u0159ebo\u0148, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ewe","sequence":"additional","affiliation":[{"name":"Laboratory of Algal Biotechnology-Centre Algatech, Institute of Microbiology of the Czech Academy of Sciences, 37901 T\u0159ebo\u0148, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7084-4204","authenticated-orcid":false,"given":"Kumar","family":"Saurav","sequence":"additional","affiliation":[{"name":"Laboratory of Algal Biotechnology-Centre Algatech, Institute of Microbiology of the Czech Academy of Sciences, 37901 T\u0159ebo\u0148, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1524-475X.1994.20305.x","article-title":"Definitions and guidelines for assessment of wounds and evaluation of healing","volume":"2","author":"Lazarus","year":"1994","journal-title":"Wound Repair Regen."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1067\/msg.2001.111167","article-title":"Wound healing: Biologic features and approaches to maximize healing trajectories","volume":"38","author":"Robson","year":"2001","journal-title":"Curr. 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