{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:15:30Z","timestamp":1774685730809,"version":"3.50.1"},"reference-count":53,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda de Mexico (CONACYT)","award":["A1-S-10616 CB 2017\u20132018"],"award-info":[{"award-number":["A1-S-10616 CB 2017\u20132018"]}]},{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda de Mexico (CONACYT)","award":["266273"],"award-info":[{"award-number":["266273"]}]},{"name":"CONACYT","award":["A1-S-10616 CB 2017\u20132018"],"award-info":[{"award-number":["A1-S-10616 CB 2017\u20132018"]}]},{"name":"CONACYT","award":["266273"],"award-info":[{"award-number":["266273"]}]},{"name":"Fundaci\u00f3n IMSS, A.C.","award":["A1-S-10616 CB 2017\u20132018"],"award-info":[{"award-number":["A1-S-10616 CB 2017\u20132018"]}]},{"name":"Fundaci\u00f3n IMSS, A.C.","award":["266273"],"award-info":[{"award-number":["266273"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Current antineoplastic agents present multiple disadvantages, driving an ongoing search for new and better compounds. Four lupane-type triterpenes, 3\u03b1,24-dihydroxylup-20(29)-en-28-oic acid (1), 3\u03b1,23-dihydroxy-30-oxo-lup-20(29)-en-28-oic acid (2), 3\u03b1,23-O-isopropylidenyl-3\u03b1,23-dihydroxylup-20(29)-en-28-oic acid (3), and 3\u03b1,23-dihydroxylup-20(29)-en-28-oic acid (4), previously isolated from Phoradendron wattii, were evaluated on two cell lines of chronic (K562) and acute (HL60) myeloid leukemia. Compounds 1, 2, and 4 decreased cell viability and inhibit proliferation, mainly in K562, and exhibited an apoptotic effect from 24 h of treatment. Of particular interest is compound 2, which caused arrest in active phases (G2\/M) of the cell cycle, as shown by in silico study of the CDK1\/Cyclin B\/Csk2 complex by molecular docking. This compound [3\u03b1,23-dihydroxy-30-oxo-lup-20(29)-en-28-oic acid] s a promising candidate for incorporation into cancer treatments and deserves further study.<\/jats:p>","DOI":"10.3390\/molecules27175616","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T01:50:51Z","timestamp":1661997051000},"page":"5616","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Apoptotic and Cell Cycle Effects of Triterpenes Isolated from Phoradendron wattii on Leukemia Cell Lines"],"prefix":"10.3390","volume":"27","author":[{"given":"L\u00eda S.","family":"Valencia-Chan","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica Yucat\u00e1n, Unidad M\u00e9dica de Alta Especialidad, Centro M\u00e9dico Ignacio Garc\u00eda T\u00e9llez, Instituto Mexicano del Seguro Social (IMSS), Calle 41 No. 439, Col. Industrial, M\u00e9rida 97200, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3029-4241","authenticated-orcid":false,"given":"Dafn\u00e9","family":"Moreno-Lorenzana","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Oncol\u00f3gica, Hospital de Oncolog\u00eda, Centro M\u00e9dico Nacional, Instituto Mexicano del Seguro Social (IMSS), Avenida Cuauht\u00e9moc 330, Ciudad de Mexico 06720, Mexico"},{"name":"CONACyT\u2013Instituto Nacional de Pediatr\u00eda (INP), Avenida Insurgentes Sur 1582, Cr\u00e9dito Constructor, Ciudad de Mexico 03940, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy Josu\u00e9","family":"Ceballos-Cruz","sequence":"additional","affiliation":[{"name":"Unidad de Biotecnolog\u00eda, Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n (CICY), Calle 43 No. 130, Col. Chuburn\u00e1 de Hidalgo, M\u00e9rida 97205, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-501X","authenticated-orcid":false,"given":"Sergio R.","family":"Peraza-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Unidad de Biotecnolog\u00eda, Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n (CICY), Calle 43 No. 130, Col. Chuburn\u00e1 de Hidalgo, M\u00e9rida 97205, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4542-1023","authenticated-orcid":false,"given":"Antonieta","family":"Ch\u00e1vez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Oncol\u00f3gica, Hospital de Oncolog\u00eda, Centro M\u00e9dico Nacional, Instituto Mexicano del Seguro Social (IMSS), Avenida Cuauht\u00e9moc 330, Ciudad de Mexico 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9204-6062","authenticated-orcid":false,"given":"Rosa E.","family":"Moo-Puc","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica Yucat\u00e1n, Unidad M\u00e9dica de Alta Especialidad, Centro M\u00e9dico Ignacio Garc\u00eda T\u00e9llez, Instituto Mexicano del Seguro Social (IMSS), Calle 41 No. 439, Col. 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