{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:35:26Z","timestamp":1793918126663,"version":"4.8.0"},"reference-count":48,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973671"],"award-info":[{"award-number":["81973671"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZR2019BB071"],"award-info":[{"award-number":["ZR2019BB071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZR2020MH222"],"award-info":[{"award-number":["ZR2020MH222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["81973671"],"award-info":[{"award-number":["81973671"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019BB071"],"award-info":[{"award-number":["ZR2019BB071"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MH222"],"award-info":[{"award-number":["ZR2020MH222"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Due to the body\u2019s systemic distribution of photothermal agents (PTAs), and to the imprecise exposure of lasers, photothermal therapy (PTT) is challenging to use in treating tumor sites selectively. Striving for PTT with high selectivity and precise treatment is nevertheless important, in order to raise the survival rate of cancer patients and lower the likelihood of adverse effects on other body sections. Here, we studied cold atmospheric plasma (CAP) as a supplementary procedure to enhance selectivity of PTT for cancer, using the classical photothermic agent\u2019s gold nanostars (AuNSs). In in vitro experiments, CAP decreases the effective power of PTT: the combination of PTT with CAP at lower power has similar cytotoxicity to that using higher power irradiation alone. In in vivo experiments, combination therapy can achieve rapid tumor suppression in the early stages of treatment and reduce side effects to surrounding normal tissues, compared to applying PTT alone. This research provides a strategy for the use of selective PTT for cancer, and promotes the clinical transformation of CAP.<\/jats:p>","DOI":"10.3390\/molecules27185941","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T22:37:28Z","timestamp":1663108648000},"page":"5941","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cold Atmospheric Plasma Activates Selective Photothermal Therapy of Cancer"],"prefix":"10.3390","volume":"27","author":[{"given":"Jiamin","family":"Qin","sequence":"first","affiliation":[{"name":"School of Pharmacy, Weifang Medical University, Weifang 261053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Weifang Medical University, Weifang 261053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojuan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Skin, Weifang Hospital of Traditional Chinese Medicine, Weifang 261000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Weifang Medical University, Weifang 261053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Weifang Medical University, Weifang 261053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Weifang Medical University, Weifang 261053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yapei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Michigan State University, East Lansing, MI 48824, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfa","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering and Environmental Chemistry, Weifang University, Weifang 261061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6761-3408","authenticated-orcid":false,"given":"Jin","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Weifang Medical University, Weifang 261053, China"},{"name":"Collaborative Innovation Center for Target Drug Delivery System, Weifang Medical University, Weifang 261053, China"},{"name":"Shandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang 261053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Weifang Medical University, Weifang 261053, China"},{"name":"Collaborative Innovation Center for Target Drug Delivery System, Weifang Medical University, Weifang 261053, China"},{"name":"Shandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang 261053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4321-9024","authenticated-orcid":false,"given":"Jinlong","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Weifang Medical University, Weifang 261053, China"},{"name":"Collaborative Innovation Center for Target Drug Delivery System, Weifang Medical University, Weifang 261053, China"},{"name":"Shandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang 261053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/ijc.33188","article-title":"Intracellular prodrug gene therapy for cancer mediated by tumor cell suicide gene exosomes","volume":"148","author":"Altanerova","year":"2020","journal-title":"Int. J. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.2147\/IJN.S239751","article-title":"Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment","volume":"15","author":"Wang","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3322\/caac.21706","article-title":"Integrative oncology: Addressing the global challenges of cancer prevention and treatment","volume":"72","author":"Mao","year":"2021","journal-title":"CA A Cancer J. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/CM9.0000000000002108","article-title":"Cancer statistics in China and United States, 2022: Profiles, trends, and determinants","volume":"135","author":"Xia","year":"2022","journal-title":"Chin. Med. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13045-021-01096-0","article-title":"Nanomaterials for cancer therapy: Current progress and perspectives","volume":"14","author":"Cheng","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"111429","DOI":"10.1016\/j.jinorgbio.2021.111429","article-title":"3D CoPt nanostructures hybridized with iridium complexes for multimodal imaging and combined photothermal-chemotherapy","volume":"219","author":"Zhang","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e202115939","DOI":"10.1002\/anie.202115939","article-title":"Intercalation-Activated Layered MoO3 Nanobelts as Biodegradable Nanozymes for Tu-mor-Specific Photo-Enhanced Catalytic Therapy","volume":"61","author":"Zhou","year":"2022","journal-title":"Angew Chem. Int. Ed Engl."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6126","DOI":"10.1039\/D2CS00236A","article-title":"Layered dou-ble hydroxide-based nanomaterials for biomedical applications","volume":"51","author":"Hu","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"17772","DOI":"10.1039\/D0DT03031G","article-title":"Ionic liquid induced highly dense assembly of porphyrin in MOF nanosheets for photodynamic therapy","volume":"49","author":"Qin","year":"2020","journal-title":"Dalton Trans."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"7253","DOI":"10.1039\/D0TB01063D","article-title":"Cancer cell membrane-coated gold nano-rods for photothermal therapy and radiotherapy on oral squamous cancer","volume":"8","author":"Sun","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/s12951-021-01080-3","article-title":"Recent advances in selective photothermal therapy of tumor","volume":"19","author":"Zhao","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1039\/D0CS00664E","article-title":"Second near-infrared photothermal materials for combinational nanotheranostics","volume":"50","author":"Xu","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.jcis.2021.07.134","article-title":"Selective thermo-therapy of tumor by self-regulating photothermal conversion system","volume":"605","author":"Zhao","year":"2022","journal-title":"J. Colloid. Interface Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"9328","DOI":"10.1021\/acs.inorgchem.2c01091","article-title":"Growth of Cu2O Nanoparticles on Two-Dimensional Zr-Ferrocene-Metal-Organic Frame-work Nanosheets for Photothermally Enhanced Chemodynamic Antibacterial Therapy","volume":"61","author":"Zhao","year":"2022","journal-title":"Inorg. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s13046-021-02105-3","article-title":"Dendrimer-modified gold nanorods as a platform for combinational gene therapy and photothermal therapy of tumors","volume":"40","author":"Ye","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Motaln, H., Recek, N., and Rogelj, B. (2021). Intracellular Responses Triggered by Cold Atmospheric Plasma and Plasma-Activated Media in Cancer Cells. Molecules, 26.","DOI":"10.3390\/molecules26051336"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"166","DOI":"10.7150\/thno.36999","article-title":"pH-responsive perylenediimide nanoparticles for cancer tri-modality imaging and photothermal therapy","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.1021\/acsnano.0c08790","article-title":"Temperature-Sensitive Lipid-Coated Carbon Nanotubes for Synergistic Photothermal Therapy and Gene Therapy","volume":"15","author":"Zhao","year":"2021","journal-title":"ACS Nano"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Boeckmann, L., Sch\u00e4fer, M., Bernhardt, T., Semmler, M.L., Jung, O., Ojak, G., Fischer, T., Peters, K., Nebe, B., and M\u00fcller-Hilke, B. (2020). Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment. Appl. Sci., 10.","DOI":"10.3390\/app10196898"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Jacoby, J.M., Strakeljahn, S., Nitsch, A., Bekeschus, S., Hinz, P., Mustea, A., Ekkernkamp, A., Tzvetkov, M.V., Haralambiev, L., and Stope, M.B. (2020). An Innovative Therapeutic Option for the Treatment of Skeletal Sar-comas: Elimination of Osteo- and Ewing\u2019s Sarcoma Cells Using Physical Gas Plasma. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124460"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Aryal, S., and Bisht, G. (2017). New Paradigm for a Targeted Cancer Therapeutic Approach: A Short Review on Potential Synergy of Gold Nanoparticles and Cold Atmospheric Plasma. Biomedicines, 5.","DOI":"10.3390\/biomedicines5030038"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zubor, P., Wang, Y., Liskova, A., Samec, M., Koklesova, L., Dankova, Z., D\u00f8rum, A., Kajo, K., Dvorska, D., and Lucansky, V. (2020). Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21217988"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Verloy, R., Privat-Maldonado, A., Smits, E., and Bogaerts, A. (2020). Cold Atmospheric Plasma Treatment for Pancreatic Cancer-The Importance of Pancreatic Stellate Cells. Cancers, 12.","DOI":"10.3390\/cancers12102782"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Semmler, M.L., Bekeschus, S., Sch\u00e4fer, M., Bernhardt, T., Fischer, T., Witzke, K., Seebauer, C., Rebl, H., Grambow, E., and Vollmar, B. (2020). Molecular Mechanisms of the Efficacy of Cold Atmospheric Pressure Plasma (CAP) in Cancer Treatment. Cancers, 12.","DOI":"10.3390\/cancers12020269"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s10495-021-01682-0","article-title":"Programmed cell death, redox imbalance, and cancer therapeutics","volume":"26","author":"Dai","year":"2021","journal-title":"Apoptosis"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Lee, J.H., Om, J.Y., Kim, Y.H., Kim, K.M., Choi, E.H., and Kim, K.N. (2016). Selective Killing Effects of Cold Atmospheric Pressure Plasma with NO Induced Dysfunction of Epidermal Growth Factor Receptor in Oral Squamous Cell Carcinoma. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150279"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.freeradbiomed.2018.10.429","article-title":"Cold atmospheric plasma and iron oxide-based magnetic nanoparticles for synergetic lung cancer therapy","volume":"130","author":"Li","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1038\/s41596-021-00521-5","article-title":"Evaluation of the effects of cold atmospheric plasma and plasma-treated liquids in cancer cell cultures","volume":"16","author":"Tornin","year":"2021","journal-title":"Nat. Protoc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"abg5686","DOI":"10.1126\/sciadv.abg5686","article-title":"Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment","volume":"7","author":"Chen","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Bengtson, C., and Bogaerts, A. (2020). On the Anti-Cancer Effect of Cold Atmospheric Plasma and the Possible Role of Catalase-Dependent Apoptotic Pathways. Cells, 9.","DOI":"10.3390\/cells9102330"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Dai, X., Bazaka, K., Thompson, E.W., and Ostrikov, K.K. (2020). Cold Atmospheric Plasma: A Promising Con-troller of Cancer Cell States. Cancers, 12.","DOI":"10.3390\/cancers12113360"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1073\/pnas.1917891117","article-title":"Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy","volume":"117","author":"Chen","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s12951-021-00933-1","article-title":"Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy","volume":"19","author":"Hu","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"14577","DOI":"10.1021\/acsami.1c00184","article-title":"Folic Acid and Poly(ethylene glycol) Decorated Paclitaxel Nanocrystals Exhibit Enhanced Stability and Breast Cancer-Targeting Capability","volume":"13","author":"Zhao","year":"2021","journal-title":"ACS Appl. Mater Interfaces"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1021\/acs.molpharmaceut.0c01008","article-title":"Folic Acid-Modified Erythrocyte Membrane Loading Dual Drug for Targeted and Chemo-Photothermal Synergistic Cancer Therapy","volume":"18","author":"Chen","year":"2020","journal-title":"Mol. Pharm."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"111558","DOI":"10.1016\/j.jinorgbio.2021.111558","article-title":"Triformyl cholic acid and folic acid functionalized magnetic graphene oxide nanocomposites: Multiple-targeted dual-modal synergis-tic chemotherapy\/photothermal therapy for liver cancer","volume":"223","author":"Gong","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Dallari, C., Capitini, C., Calamai, M., Trabocchi, A., Pavone, F.S., and Credi, C. (2021). Gold Nanostars Bioconju-gation for Selective Targeting and SERS Detection of Biofluids. Nanomaterials, 11.","DOI":"10.3390\/nano11030665"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.jcis.2022.06.009","article-title":"Buffet-style Cu(II) for enhance disulfiram-based cancer therapy","volume":"624","author":"Zhao","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"100484","DOI":"10.1016\/j.apmt.2019.100484","article-title":"Clothing spiny nanoprobes against the mononuclear phagocyte system clearance in vivo: Photoacoustic diagnosis and photothermal treat-ment of early stage liver cancer with erythrocyte membrane-camouflaged gold nanostars","volume":"18","author":"Huang","year":"2020","journal-title":"Appl. Mater. Today"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6259","DOI":"10.2147\/IJN.S141164","article-title":"Photothermal ablation of inflammatory breast cancer tumor emboli using plasmonic gold nanostars","volume":"12","author":"Crawford","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-019-0360-4","article-title":"Cold atmospheric plasma and silymarin nanoemulsion synergistically inhibits human melanoma tumorigenesis via targeting HGF\/c-MET downstream pathway","volume":"17","author":"Adhikari","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.actbio.2016.09.030","article-title":"Cold atmospheric plasma (CAP) surface nanomodified 3D printed polylactic acid (PLA) scaffolds for bone regeneration","volume":"46","author":"Wang","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bios.2016.04.072","article-title":"Multifunctional graphene micro-islands: Rapid, low-temperature plasma-enabled synthesis and facile integration for bioengineering and genosensing applications","volume":"89","author":"Pineda","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.ijbiomac.2019.10.268","article-title":"Study on the atmospheric cold plasma (ACP) treatment of zein film: Surface properties and cytocompatibility","volume":"153","author":"Dong","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s11706-021-0576-2","article-title":"A nanosystem of cop-per(II)-disulfiram for cancer treatment with high efficacy and few side effects","volume":"15","author":"Zhao","year":"2021","journal-title":"Front. Mater. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/smll.201503319","article-title":"Polypyrrole Composite Nanoparticles with Morphology-Dependent Photothermal Effect and Immunological Responses","volume":"12","author":"Tian","year":"2016","journal-title":"Small"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"108820","DOI":"10.1016\/j.biopha.2019.108820","article-title":"Nasopharyngeal cancer combination chemoradiation therapy based on folic acid modified, gefitinib and yttrium 90 co-loaded, core-shell structured lipid-polymer hybrid nanoparticles","volume":"114","author":"Yugui","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"7689","DOI":"10.1038\/s41598-018-25990-9","article-title":"Comparison of Direct and Indirect cold atmospheric-pressure plasma methods in the B16F10 melanoma cancer cells treatment","volume":"8","author":"Saadati","year":"2018","journal-title":"Sci. Rep."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/18\/5941\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:30:17Z","timestamp":1760142617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/18\/5941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,13]]},"references-count":48,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["molecules27185941"],"URL":"https:\/\/doi.org\/10.3390\/molecules27185941","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,13]]}}}