{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:53:37Z","timestamp":1787756017144,"version":"build-2784847793"},"reference-count":29,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe (IPPPP)"},{"name":"Funda\u00e7\u00e3o Arauc\u00e1ria scholarship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The plant Miconia albicans (Sw.) Triana has been popularly used in Brazil to treat chronic inflammatory disturbances, such as osteoarthritis. This disease affects 250 million people worldwide, and is associated with intense pain and loss of articular function. There is a lack of information about the phytochemistry and bioactivity of M. albicans. Therefore, this study determined the chemical composition of some extracts and evaluated their cytotoxicity, along with their antioxidant and anti-inflammatory, activities using in vitro models. Aqueous and ethanolic extracts were prepared. Afterwards, a liquid\u2013liquid partition was developed using chloroform, ethyl acetate, and n-butanol. The extracts were characterized by LC\u2013MS, and their biological activities were evaluated on epithelial cells (Vero), tumoral hepatic cells (Hep-G2), and THP-1 macrophages. LC\u2013MS analyses identified several flavonoids in all fractions, such as quercetin, myricetin, and their glycosides. The crude extracts and n-butanol fractions did not present cytotoxicity to the cells. The non-toxic fractions presented significant antioxidant activity when evaluated in terms of DPPH scavenging activity, lipid peroxidation, and ROS inhibition. THP-1 macrophages treated with the n-butanol fraction (250 \u00b5g\/mL) released fewer pro-inflammatory cytokines, even in the presence of LPS. In the future, it will be necessary to identify the phytochemicals that are responsible for anti-inflammatory effects for the discovery of new drugs. In vivo studies on M. albicans extracts are still required to confirm their possible mechanisms of action.<\/jats:p>","DOI":"10.3390\/molecules27185954","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T22:37:28Z","timestamp":1663108648000},"page":"5954","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phytochemical Evaluation and Anti-Inflammatory Potential of Miconia albicans (Sw.) Triana Extracts"],"prefix":"10.3390","volume":"27","author":[{"given":"Mariana Inocencio","family":"Manzano","sequence":"first","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"},{"name":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana","family":"Centa","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"},{"name":"Laborat\u00f3rio de Pesquisa Translacional em Sa\u00fade, Universidade Alto Vale do Rio do Peixe, Rua Victor Baptista Adami, 800, Centro, Ca\u00e7ador CEP 89500-000, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0488-3010","authenticated-orcid":false,"given":"Alan de Almeida","family":"Veiga","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayara Souza","family":"da Costa","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"},{"name":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7262-3766","authenticated-orcid":false,"given":"Sandro J. R.","family":"Bonatto","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9166-2146","authenticated-orcid":false,"given":"Lauro M.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"},{"name":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9094-2258","authenticated-orcid":false,"given":"Fhernanda Ribeiro","family":"Smiderle","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"},{"name":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"116786","DOI":"10.1016\/j.lfs.2019.116786","article-title":"The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review","volume":"234","author":"Asmaa","year":"2019","journal-title":"Life Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1136\/annrheumdis-2013-203355","article-title":"Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: Influences of age, gender and osteoarthritis affecting other joints","volume":"73","author":"Judge","year":"2014","journal-title":"Ann. Rheum. 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