{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:15:25Z","timestamp":1790806525665,"version":"4.1.0"},"reference-count":58,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["21676062"],"award-info":[{"award-number":["21676062"]}]},{"name":"National Natural Science Foundation of China","award":["21466010"],"award-info":[{"award-number":["21466010"]}]},{"name":"National Natural Science Foundation of China","award":["21504018"],"award-info":[{"award-number":["21504018"]}]},{"name":"National Natural Science Foundation of China","award":["2016010103"],"award-info":[{"award-number":["2016010103"]}]},{"name":"Guangxi Zhuang Autonomous Region","award":["21676062"],"award-info":[{"award-number":["21676062"]}]},{"name":"Guangxi Zhuang Autonomous Region","award":["21466010"],"award-info":[{"award-number":["21466010"]}]},{"name":"Guangxi Zhuang Autonomous Region","award":["21504018"],"award-info":[{"award-number":["21504018"]}]},{"name":"Guangxi Zhuang Autonomous Region","award":["2016010103"],"award-info":[{"award-number":["2016010103"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>As a biocompatible biomaterial, bagasse xylan (BX) has been widely used in the biomedical field. The low biological activity of andrographolide (AD) restricts its development, so AD with certain anticancer activity is introduced. We use chemical modification methods such as grafting and esterification to improve the biological activity and make a novel anticancer nanomaterial. On the basis of the esterification of a mixture of BX and AD with folic acid (FA), a novel anticancer nanoderivative of bagasse xylan\/andrographolide folate-g-dimethylaminoethyl methacrylate (DMAEMA)\/diethylene glycol dimethacrylate (DEGDMA) nanoparticles (FA-BX\/AD-g-DMAEMA\/DEGDMA NPs) was synthesized by introducing DMAEMA and DEGDMA monomers through a graft copolymerization and nanoprecipitation method. The effects of reaction temperature, reaction time, the initiator concentration and the mass ratio of FA-BX\/AD to mixed monomers on the grafting rate (GR) were investigated. The structure of the obtained product was characterized by FTIR, SEM, XRD and DTG. Further, molecular docking and MTT assays were performed to understand the possible docking sites with the target proteins and the anticancer activity of the product. The results showed that the GR of the obtained product was 79% under the conditions of the initiator concentration 55 mmol\/L, m (FA-BX\/AD):m (mixed monomer) = 1:2, reaction temperature 50 \u00b0C and reaction time 5 h. The inhibition rate of FA-BX\/AD-g-DMAEMA\/DEGDMA NPs on human lung cancer cells (NCI-H460) can reach 39.77 \u00b1 5.62%, which is about 7.6 times higher than that of BX. Therefore, this material may have potential applications in the development of anticancer drug or carriers and functional materials.<\/jats:p>","DOI":"10.3390\/molecules27185970","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T23:16:36Z","timestamp":1663197396000},"page":"5970","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dimethylaminoethyl Methacrylate\/Diethylene Glycol Dimethacrylate Grafted onto Folate-Esterified Bagasse Xylan\/Andrographolide Composite Nanoderivative: Synthesis, Molecular Docking and Biological Activity"],"prefix":"10.3390","volume":"27","author":[{"given":"Yue","family":"Su","sequence":"first","affiliation":[{"name":"College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufen","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heping","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Zou","sequence":"additional","affiliation":[{"name":"College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/cac2.12195","article-title":"Trends in cancer mortality in China from 2004 to 2018: A nationwide longitudinal study","volume":"41","author":"Jiang","year":"2021","journal-title":"Cancer Commun."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/CM9.0000000000002108","article-title":"Cancer statistics in China and United States, 2022: Profiles, trends, and determinants","volume":"135","author":"Xia","year":"2022","journal-title":"Chin. 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