{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:03:21Z","timestamp":1788897801859,"version":"build-2803163510"},"reference-count":30,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T00:00:00Z","timestamp":1663459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005980","name":"Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi Republik Indonesia","doi-asserted-by":"publisher","award":["NKB-1057\/UN2.RST\/HKP.05.00\/2022"],"award-info":[{"award-number":["NKB-1057\/UN2.RST\/HKP.05.00\/2022"]}],"id":[{"id":"10.13039\/501100005980","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This study aims to optimize ultrasonic-assisted natural deep eutectic solvents (NADES) based extraction from C. longa. Choline chloride-lactic acid (CCLA-H2O = 1:1, b\/v) was used to investigate the impact of various process parameters such as solvent\u2019s water content, solid loading, temperature, and extraction time. The optimal yield of 79.635 mg\/g of C. longa was achieved from extraction in 20% water content NADES with a 4% solid loading in 35 \u00b0C temperature for 1 h. Peleg\u2019s model was used to describe the kinetics of the optimized ultrasonic-assisted extraction (UAE) method, and the results were found to be compatible with experimental data. The optimum conditions obtained from C. longa extraction were then used for the extraction of C. xanthorriza and C. mangga, which give yields of 2.056 and 31.322 mg\/g, respectively. Furthermore, n-hexane was utilized as an anti-solvent in the separation process of curcuminoids extract from C. longa, C. xanthorriza, and C. mangga, which gave curcuminoid recovery of 39%, 0.74%, and 27%, respectively. Solidification of curcuminoids was also carried out using the crystallization method with n-hexane and isopropanol. However, the solution of CCLA and curcuminoids formed a homogeneous mixture with isopropanol. Hence, the curcuminoids could not be solidified due to the presence of NADES in the extract solution.<\/jats:p>","DOI":"10.3390\/molecules27186080","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T02:06:50Z","timestamp":1663553210000},"page":"6080","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Optimization of Ultrasonic\u2014Assisted Extraction (UAE) Method Using Natural Deep Eutectic Solvent (NADES) to Increase Curcuminoid Yield from Curcuma longa L., Curcuma xanthorrhiza, and Curcuma mangga Val."],"prefix":"10.3390","volume":"27","author":[{"given":"Desy","family":"Rosarina","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16424, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimas Rafi","family":"Narawangsa","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16424, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila Shaffa Rizky","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16424, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eka","family":"Sari","sequence":"additional","affiliation":[{"name":"Bioengineering & Biomedical Engineering, Research Centre CoE, Engineering Faculty, Sultan Ageng Tirtayasa University, Cilegon 42434, Indonesia"},{"name":"Chemical Engineering, Engineering Faculty, Sultan Ageng Tirtayasa University, Cilegon 42434, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9632-9964","authenticated-orcid":false,"given":"Heri","family":"Hermansyah","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16424, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.bcp.2007.08.016","article-title":"Curcumin as \"Curecumin\": From Kitchen to Clinic","volume":"75","author":"Goel","year":"2008","journal-title":"Biochem. 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