{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T10:15:18Z","timestamp":1783160118699,"version":"3.54.6"},"reference-count":32,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T00:00:00Z","timestamp":1663459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21971161"],"award-info":[{"award-number":["21971161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["TP2019039"],"award-info":[{"award-number":["TP2019039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["KJ2019B10"],"award-info":[{"award-number":["KJ2019B10"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Institutions of Higher Learning","award":["21971161"],"award-info":[{"award-number":["21971161"]}]},{"name":"Shanghai Institutions of Higher Learning","award":["TP2019039"],"award-info":[{"award-number":["TP2019039"]}]},{"name":"Shanghai Institutions of Higher Learning","award":["KJ2019B10"],"award-info":[{"award-number":["KJ2019B10"]}]},{"name":"Natural Science Foundation of Educational Committee of Anhui Province","award":["21971161"],"award-info":[{"award-number":["21971161"]}]},{"name":"Natural Science Foundation of Educational Committee of Anhui Province","award":["TP2019039"],"award-info":[{"award-number":["TP2019039"]}]},{"name":"Natural Science Foundation of Educational Committee of Anhui Province","award":["KJ2019B10"],"award-info":[{"award-number":["KJ2019B10"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Thermoresponsive dendronized gelatins (GelG1) or gelatin methacrylates (GelG1MA) were used as precursors to modulate the efficient reduction of Au(III) to form stable gold nanoparticles (AuNPs) through UV irradiation. These dendronized gelatins were obtained through the amidation of gelatin or gelatin methacrylates with dendritic oligoethylene glycols (OEGs). Crowded OEG dendrons along the gelatin backbones create a hydrophobic microenvironment, which promotes the reduction of Au(III). Gelatin backbones act as ligands through the electron-rich groups to facilitate the reduction, while the dendritic OEGs provide shielding effects through crowding to form a hydrophobic microenvironment, which not only enhances the reduction but also stabilize the formed AuNPs through encapsulation. The effects of dendron coverage on the dendronized biomacromolecules and their thermoresponsiveness on the reduction kinetics were examined. Dendronized gelatin\/AuNPs hydrogels were further prepared through the in situ photo-crosslinking of GelG1MA. The modification of natural macromolecules through dendronization presented in this report facilitates a novel platform for the environmentally friendly synthesis of noble metal nanoparticles, which may form a new strategy for developing smart nano-biosensors and nano-devices.<\/jats:p>","DOI":"10.3390\/molecules27186096","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T02:06:50Z","timestamp":1663553210000},"page":"6096","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dendronized Gelatin-Mediated Synthesis of Gold Nanoparticles"],"prefix":"10.3390","volume":"27","author":[{"given":"Yan","family":"Ding","sequence":"first","affiliation":[{"name":"International Joint Laboratory of Biomimetic and Smart Polymers, School of Materials Science & Engineering, Shanghai University, Shanghai 200444, China"},{"name":"Institute of Chemistry and Materials Science, Huaibei Normal University, Dongshan Road 100, Huaibei 235000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiacong","family":"Zhang","sequence":"additional","affiliation":[{"name":"International Joint Laboratory of Biomimetic and Smart Polymers, School of Materials Science & Engineering, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-7406","authenticated-orcid":false,"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"International Joint Laboratory of Biomimetic and Smart Polymers, School of Materials Science & Engineering, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0078-3223","authenticated-orcid":false,"given":"Afang","family":"Zhang","sequence":"additional","affiliation":[{"name":"International Joint Laboratory of Biomimetic and Smart Polymers, School of Materials Science & Engineering, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1021\/acsnano.9b09213","article-title":"Tuning Nanoparticle Interactions with Ovarian Cancer through Layer-by-Layer Modification of Surface Chemistry","volume":"14","author":"Correa","year":"2020","journal-title":"ACS Nano"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1021\/acs.biomac.9b00792","article-title":"Biomacromolecules for Tissue Engineering: Emerging Biomimetic Strategies","volume":"20","author":"Guo","year":"2019","journal-title":"Biomacromolecules"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1021\/acsmaterialslett.2c00095","article-title":"Natural Material Inspired Organic Thin-Film Transistors for Biosensing: Properties and Applications","volume":"4","author":"Ma","year":"2022","journal-title":"ACS Mater. 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