{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:37:16Z","timestamp":1789011436439,"version":"build-2803163510"},"reference-count":37,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key R&amp;D Program of China","award":["2021YFF0502900"],"award-info":[{"award-number":["2021YFF0502900"]}]},{"name":"National Key R&amp;D Program of China","award":["62175161\/61835009\/62127819\/61975132"],"award-info":[{"award-number":["62175161\/61835009\/62127819\/61975132"]}]},{"name":"National Key R&amp;D Program of China","award":["2021M702240"],"award-info":[{"award-number":["2021M702240"]}]},{"name":"National Key R&amp;D Program of China","award":["JCYJ20210324095810028\/JCYJ20210324095613036\/JCYJ20190808151215399"],"award-info":[{"award-number":["JCYJ20210324095810028\/JCYJ20210324095613036\/JCYJ20190808151215399"]}]},{"name":"National Natural Science Foundation of China","award":["2021YFF0502900"],"award-info":[{"award-number":["2021YFF0502900"]}]},{"name":"National Natural Science Foundation of China","award":["62175161\/61835009\/62127819\/61975132"],"award-info":[{"award-number":["62175161\/61835009\/62127819\/61975132"]}]},{"name":"National Natural Science Foundation of China","award":["2021M702240"],"award-info":[{"award-number":["2021M702240"]}]},{"name":"National Natural Science Foundation of China","award":["JCYJ20210324095810028\/JCYJ20210324095613036\/JCYJ20190808151215399"],"award-info":[{"award-number":["JCYJ20210324095810028\/JCYJ20210324095613036\/JCYJ20190808151215399"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021YFF0502900"],"award-info":[{"award-number":["2021YFF0502900"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["62175161\/61835009\/62127819\/61975132"],"award-info":[{"award-number":["62175161\/61835009\/62127819\/61975132"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M702240"],"award-info":[{"award-number":["2021M702240"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["JCYJ20210324095810028\/JCYJ20210324095613036\/JCYJ20190808151215399"],"award-info":[{"award-number":["JCYJ20210324095810028\/JCYJ20210324095613036\/JCYJ20190808151215399"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Basic Research Program","award":["2021YFF0502900"],"award-info":[{"award-number":["2021YFF0502900"]}]},{"name":"Shenzhen Basic Research Program","award":["62175161\/61835009\/62127819\/61975132"],"award-info":[{"award-number":["62175161\/61835009\/62127819\/61975132"]}]},{"name":"Shenzhen Basic Research Program","award":["2021M702240"],"award-info":[{"award-number":["2021M702240"]}]},{"name":"Shenzhen Basic Research Program","award":["JCYJ20210324095810028\/JCYJ20210324095613036\/JCYJ20190808151215399"],"award-info":[{"award-number":["JCYJ20210324095810028\/JCYJ20210324095613036\/JCYJ20190808151215399"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>High-quality fluorescent probes based on carbon dots (CDs) have promising applications in many fields owing to their good stability, low toxicity, high quantum yield, and low raw material price. The fluorine- and nitrogen-doped fluorescent CDs (NFCDs) with blue fluorescence was successfully synthesized using 3-aminophenol and 2,4-difluorobenzoic acid as the raw material by the hydrothermal method. The NFCDs as probe can be used to directly and indirectly detect Fe3+ (detection range: 0.1\u2013150 \u03bcM and detection limit: 0.14 \u03bcM) and ascorbic acid (AA) (detection range: 10\u201380 \u03bcM and detection limit: 0.11 \u03bcM). The NFCDs-based probe shows exceptional selectivity and strong anti-interference for Fe3+ and ascorbic acid (AA). In addition, we examined the response of NFCDs to Fe3+ and AA in living cells, which showed that the timely use of AA can reduce the effects of iron poisoning. This has important biological significance. This means that using NFCDs as fluorescent probes is beneficial for Fe3+ and AA detection and observing their dynamic changes in living cells. Thus, this work may contribute to the study of Fe3+- and AA-related diseases.<\/jats:p>","DOI":"10.3390\/molecules27196158","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T22:36:44Z","timestamp":1663713404000},"page":"6158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fluorine-Nitrogen-Codoped Carbon Dots as Fluorescent Switch Probes for Selective Fe(III) and Ascorbic Acid Sensing in Living Cells"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9862-4983","authenticated-orcid":false,"given":"Shuai","family":"Ye","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory of Photonics and Biophotonics, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Photonics and Biophotonics, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqing","family":"Guo","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Photonics and Biophotonics, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiantong","family":"Yu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Photonics and Biophotonics, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Song","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Photonics and Biophotonics, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengju","family":"Zeng","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Photonics and Biophotonics, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7833-4711","authenticated-orcid":false,"given":"Junle","family":"Qu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Photonics and Biophotonics, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Photonics and Biophotonics, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3796-6952","authenticated-orcid":false,"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Photonics and Biophotonics, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.snb.2016.11.150","article-title":"D-penicillamine-functionalized graphene quantum dots for fluorescent detection of Fe3+ in iron supplement oral liquids","volume":"243","author":"Xuan","year":"2017","journal-title":"Sens. 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