{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:38:56Z","timestamp":1792805936522,"version":"4.5.0"},"reference-count":93,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Egyptian Ministry of Higher Education-Mission Sector","award":["ADDED MM 14\/19"],"award-info":[{"award-number":["ADDED MM 14\/19"]}],"id":[{"id":"https:\/\/ror.org\/0512bh102","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Egyptian Ministry of Higher Education-Mission Sector","award":["EP\/T022167\/1"],"award-info":[{"award-number":["EP\/T022167\/1"]}],"id":[{"id":"https:\/\/ror.org\/0512bh102","id-type":"ROR","asserted-by":"crossref"}]},{"name":"N8 research partnership","award":["ADDED MM 14\/19"],"award-info":[{"award-number":["ADDED MM 14\/19"]}]},{"name":"N8 research partnership","award":["EP\/T022167\/1"],"award-info":[{"award-number":["EP\/T022167\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The NLRP3 inflammasome is currently an exciting target for drug discovery due to its role in various inflammatory diseases; however, to date, no NLRP3 inhibitors have reached the clinic. Several studies have used natural products as hit compounds to facilitate the design of novel selective NLRP3 inhibitors. Here, we review selected natural products reported in the literature as NLRP3 inhibitors, with a particular focus on those targeting gout. To complement this survey, we also report a virtual screen of the ZINC20 natural product database, predicting favored chemical features that can aid in the design of novel small molecule NLRP3 inhibitors.<\/jats:p>","DOI":"10.3390\/molecules27196213","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T05:33:14Z","timestamp":1663824794000},"page":"6213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A Selective Review and Virtual Screening Analysis of Natural Product Inhibitors of the NLRP3 Inflammasome"],"prefix":"10.3390","volume":"27","author":[{"given":"Sherihan","family":"El-Sayed","sequence":"first","affiliation":[{"name":"Division of Pharmacy and Optometry, School of Health Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Oxford Road, Manchester M13 9PT, UK"},{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3831-9151","authenticated-orcid":false,"given":"Sally","family":"Freeman","sequence":"additional","affiliation":[{"name":"Division of Pharmacy and Optometry, School of Health Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Oxford Road, Manchester M13 9PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Bryce","sequence":"additional","affiliation":[{"name":"Division of Pharmacy and Optometry, School of Health Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Oxford Road, Manchester M13 9PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.molmed.2018.01.004","article-title":"Inflammasome, inflammation, and tissue homeostasis","volume":"24","author":"Rathinam","year":"2018","journal-title":"Trends Mol. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: Mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41586-019-1295-z","article-title":"Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome","volume":"570","author":"Sharif","year":"2019","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"El-Sayed, S., Freeman, S., and Bryce, R.A. (2022). Probing the effect of NEK7 and cofactor interactions on dynamics of NLRP3 monomer using molecular simulation. Prot. Sci., In press.","DOI":"10.1002\/pro.4420"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: Molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ribeiro, D.E., Roncalho, A.L., Glaser, T., Ulrich, H., Wegener, G., and Joca, S. (2019). P2X7 receptor signaling in stress and depression. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20112778"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms12504","article-title":"Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer\u2019s disease in rodent models","volume":"7","author":"Daniels","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_10","first-page":"1","article-title":"Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors","volume":"10","author":"Yang","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/ars.2014.5994","article-title":"Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?","volume":"22","author":"Abais","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ni.2237","article-title":"Regulation of inflammasome signaling","volume":"13","author":"Rathinam","year":"2012","journal-title":"Nat. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/ni.3333","article-title":"NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component","volume":"17","author":"Shi","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature16959","article-title":"NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux","volume":"530","author":"He","year":"2016","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bcp.2014.08.013","article-title":"Free fatty acids as modulators of the NLRP3 inflammasome in obesity\/type 2 diabetes","volume":"92","author":"Esser","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00395-017-0663-9","article-title":"Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases","volume":"113","author":"Liu","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice","volume":"493","author":"Heneka","year":"2013","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.abb.2019.01.031","article-title":"The NLRP3 inflammasome-interleukin 1 pathway as a therapeutic target in gout","volume":"670","author":"Szekanecz","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar2952","article-title":"Gout. Mechanisms of inflammation in gout","volume":"12","author":"Busso","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"ref_21","first-page":"39","article-title":"The role of the NLRP3 inflammasome in gout","volume":"4","author":"Kingsbury","year":"2011","journal-title":"J. Inflamm. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/HM9.0000000000000016","article-title":"The development from hyperuricemia to gout: Key mechanisms and natural products for treatment","volume":"2","author":"Liu","year":"2022","journal-title":"Acupunct. Herb. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrrheum.2017.155","article-title":"Inflammation in gout: Mechanisms and therapeutic targets","volume":"13","author":"So","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/imr.12833","article-title":"Urate-induced immune programming: Consequences for gouty arthritis and hyperuricemia","volume":"294","author":"Popp","year":"2020","journal-title":"Immunol. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"111822","DOI":"10.1016\/j.ejmech.2019.111822","article-title":"Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases","volume":"185","author":"Zhang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nature Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e2121353119","DOI":"10.1073\/pnas.2121353119","article-title":"Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation","volume":"119","author":"Ohto","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.1016\/j.cell.2021.11.011","article-title":"NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation","volume":"184","author":"Andreeva","year":"2021","journal-title":"Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41586-022-04467-w","article-title":"Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3","volume":"604","author":"Hochheiser","year":"2022","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41589-019-0278-6","article-title":"MCC950 closes the active conformation of NLRP3 to an inactive state","volume":"15","author":"Arostegui","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41589-019-0277-7","article-title":"MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition","volume":"15","author":"Coll","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1042\/CS20210865","article-title":"Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease","volume":"136","author":"Jha","year":"2022","journal-title":"Clin. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"175091","DOI":"10.1016\/j.ejphar.2022.175091","article-title":"Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome","volume":"928","author":"Li","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8158","DOI":"10.1021\/acsomega.2c00125","article-title":"Structure\u2013Stability Relationship of NLRP3 Inflammasome-Inhibiting Sulfonylureas","volume":"7","author":"Keuler","year":"2022","journal-title":"ACS Omega"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"167309","DOI":"10.1016\/j.jmb.2021.167309","article-title":"Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition","volume":"433","author":"Dekker","year":"2021","journal-title":"J. Mol. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.14336\/AD.2021.0318","article-title":"Targeting NLRP3 Inflammasome in the Treatment Of Diabetes and Diabetic Complications: Role of Natural Compounds from Herbal Medicine","volume":"12","author":"Bai","year":"2021","journal-title":"Aging Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1002\/ptr.7118","article-title":"Medicinal plants and bioactive natural products as inhibitors of NLRP3 inflammasome","volume":"35","author":"Bagherniya","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lee, J.H., Kim, H.J., Kim, J.U., Yook, T.H., Kim, K.H., Lee, J.Y., and Yang, G. (2021). A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer\u2019s and Parkinson\u2019s Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031324"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s10787-021-00918-4","article-title":"Phenols and terpenoids: Natural products as inhibitors of NLRP3 inflammasome in cardiovascular diseases","volume":"30","author":"Hua","year":"2022","journal-title":"Inflammopharmacology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"591393","DOI":"10.3389\/fphar.2020.591393","article-title":"Natural products that target the NLRP3 inflammasome to treat fibrosis","volume":"11","author":"Ding","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"104584","DOI":"10.1016\/j.jff.2021.104584","article-title":"Dietary supplementation of camel whey protein attenuates heat stress-induced liver injury by inhibiting NLRP3 inflammasome activation through the HMGB1\/RAGE signalling pathway","volume":"84","author":"Du","year":"2021","journal-title":"J. Funct. Foods"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3390\/biomedicines9020136","article-title":"Anti-NLRP3 inflammasome natural compounds: An update","volume":"9","author":"Liu","year":"2021","journal-title":"Biomedicines"},{"key":"ref_43","first-page":"743","article-title":"A review on the role of quinones in cardiovascular disease via inhibiting nlrp3 inflammasome","volume":"78","author":"ZHOU","year":"2021","journal-title":"Acta Pol. Pharm."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"105710","DOI":"10.1016\/j.phrs.2021.105710","article-title":"Phytochemical inhibitors of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"170","author":"Efferth","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"105388","DOI":"10.1016\/j.phrs.2020.105388","article-title":"Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury","volume":"164","author":"Zou","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1189\/jlb.3A0114-005RR","article-title":"Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation","volume":"96","author":"Honda","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"126944","DOI":"10.1016\/j.bmcl.2019.126944","article-title":"Development of novel NLRP3-XOD dual inhibitors for the treatment of gout","volume":"30","author":"Wang","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"107879","DOI":"10.1016\/j.intimp.2021.107879","article-title":"Celastrol inhibits rheumatoid arthritis through the ROS-NF-\u03baB-NLRP3 inflammasome axis","volume":"98","author":"Jing","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"67300","DOI":"10.18632\/oncotarget.18619","article-title":"Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation","volume":"8","author":"Yu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Ay, M., Charli, A., Jin, H., Anantharam, V., Kanthasamy, A., and Kanthasamy, A.G. (2021). Quercetin. Nutraceuticals, Elsevier.","DOI":"10.1016\/B978-0-12-821038-3.00043-4"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1039\/b311404j","article-title":"Anthocyanins and other flavonoids","volume":"21","author":"Williams","year":"2004","journal-title":"Nat. Prod. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1039\/D0FO01900C","article-title":"Quercetin improves cognitive disorder in aging mice by inhibiting NLRP3 inflammasome activation","volume":"12","author":"Li","year":"2021","journal-title":"Food Funct."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s10787-017-0356-x","article-title":"Quercetin inhibits gout arthritis in mice: Induction of an opioid-dependent regulation of inflammasome","volume":"25","author":"Mizokami","year":"2017","journal-title":"Inflammopharmacology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.jsps.2022.04.013","article-title":"A review on benefits of quercetin in hyperuricemia and gouty arthritis","volume":"30","author":"Nutmakul","year":"2022","journal-title":"Saudi Pharm. J."},{"key":"ref_55","first-page":"3","article-title":"Application of NMR spectroscopy in plant polyphenols associated with human health","volume":"Volume 2","author":"Rupasinghe","year":"2015","journal-title":"Applications of NMR Spectroscopy"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11101-017-9507-3","article-title":"Procyanidins: A comprehensive review encompassing structure elucidation via mass spectrometry","volume":"17","author":"Rue","year":"2018","journal-title":"Phytochem. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-017-0849-y","article-title":"Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression","volume":"14","author":"Liu","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"ref_58","unstructured":"(2022, January 07). OpenEye Scientific Software. Available online: https:\/\/www.eyesopen.com."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.foodchem.2016.09.178","article-title":"A computational investigation on the structure, global parameters and antioxidant capacity of a polyphenol, Gallic acid","volume":"220","author":"Rajan","year":"2017","journal-title":"Food Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"580208","DOI":"10.3389\/fimmu.2020.580208","article-title":"Impact of gallic acid on gut health: Focus on the gut microbiome, immune response, and mechanisms of action","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"580593","DOI":"10.3389\/fimmu.2020.580593","article-title":"Gallic acid alleviates gouty arthritis by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling","volume":"11","author":"Lin","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1021\/acs.jmedchem.1c01936","article-title":"SAR of Novel 3-Arylisoquinolinones: Meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules","volume":"65","author":"Elhemely","year":"2022","journal-title":"J. Med. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.jmb.2014.02.005","article-title":"The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization","volume":"426","author":"Prota","year":"2014","journal-title":"J. Mol. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1189\/jlb.1012510","article-title":"Technical advance: Inhibition of neutrophil chemotaxis by colchicine is modulated through viscoelastic properties of subcellular compartments","volume":"94","author":"Paschke","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00011-022-01540-y","article-title":"Colchicine for COVID-19: Targeting NLRP3 inflammasome to blunt hyperinflammation","volume":"71","author":"Bonaventura","year":"2022","journal-title":"Inflamm. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.clinthera.2014.07.017","article-title":"Mechanism of action of colchicine in the treatment of gout","volume":"36","author":"Dalbeth","year":"2014","journal-title":"Clin. Ther."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-04947-6","article-title":"Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity","volume":"9","author":"He","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tips.2022.04.003","article-title":"NLRP3 and pyroptosis blockers for treating inflammatory diseases","volume":"43","author":"Coll","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12272-021-01307-9","article-title":"Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases","volume":"44","author":"Seok","year":"2021","journal-title":"Arch. Pharm. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"9792","DOI":"10.1074\/jbc.M109.082305","article-title":"Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome","volume":"285","author":"Juliana","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Francomano, F., Caruso, A., Barbarossa, A., Fazio, A., La Torre, C., Ceramella, J., Mallamaci, R., Saturnino, C., Iacopetta, D., and Sinicropi, M.S. (2019). \u03b2-Caryophyllene: A sesquiterpene with countless biological properties. Appl. Sci., 9.","DOI":"10.3390\/app9245420"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.freeradbiomed.2021.01.046","article-title":"\u03b2-Caryophyllene, a natural bicyclic sesquiterpene attenuates \u03b2-adrenergic agonist-induced myocardial injury in a cannabinoid receptor-2 dependent and independent manner","volume":"167","author":"Meeran","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"651305","DOI":"10.3389\/fphar.2021.651305","article-title":"\u03b2-Caryophyllene Ameliorates MSU-Induced Gouty Arthritis and Inflammation Through Inhibiting NLRP3 and NF-\u03baB Signal Pathway: In Silico and In Vivo","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep38622","article-title":"Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: A novel strategy to treat acute gout","volume":"6","author":"Lee","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Hewlings, S.J., and Kalman, D.S. (2017). Curcumin: A review of its effects on human health. Foods, 6.","DOI":"10.3390\/foods6100092"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1021\/acschemneuro.1c00153","article-title":"Neuroprotective effects of curcumin in cerebral ischemia: Cellular and molecular mechanisms","volume":"12","author":"Subedi","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"104921","DOI":"10.1016\/j.phrs.2020.104921","article-title":"Curcumin: An inflammasome silencer","volume":"159","author":"Hasanzadeh","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_78","first-page":"368","article-title":"Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis","volume":"8","author":"Zhang","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1021\/acs.jafc.5b00244","article-title":"Degradation of curcumin: From mechanism to biological implications","volume":"63","author":"Schneider","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1007\/s12274-021-3864-3","article-title":"Natural product curcumin-based coordination nanoparticles for treating osteoarthritis via targeting Nrf2 and blocking NLRP3 inflammasome","volume":"15","author":"Zhou","year":"2022","journal-title":"Nano Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/art.41245","article-title":"Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3-Driven Inflammation and Gouty Arthritis","volume":"72","author":"Yang","year":"2020","journal-title":"Arthritis Rheumatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"47","DOI":"10.5661\/bger-28-47","article-title":"Plant natural products: History, limitations and the potential of cambial meristematic cells","volume":"28","author":"Yun","year":"2012","journal-title":"Biotechnol. Genet. Eng. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: Advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.tips.2004.12.002","article-title":"Overcoming limitations of natural anticancer drugs by combining with artificial agents","volume":"26","author":"Blagosklonny","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_85","first-page":"17","article-title":"The success of natural products in drug discovery","volume":"4","author":"Lahlou","year":"2013","journal-title":"Sci. Res."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Thomford, N.E., Senthebane, D.A., Rowe, A., Munro, D., Seele, P., Maroyi, A., and Dzobo, K. (2018). Natural products for drug discovery in the 21st century: Innovations for novel drug discovery. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061578"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"13633","DOI":"10.1021\/acs.jmedchem.1c01007","article-title":"Discovery of novel pterostilbene-based derivatives as potent and orally active NLRP3 inflammasome inhibitors with inflammatory activity for colitis","volume":"64","author":"Chen","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1084\/jem.20171419","article-title":"Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders","volume":"214","author":"Jiang","year":"2017","journal-title":"J. Exp. Med."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Omar, F., Tareq, A.M., Alqahtani, A.M., Dhama, K., Sayeed, M.A., Emran, T.B., and Simal-Gandara, J. (2021). Plant-based indole alkaloids: A comprehensive overview from a pharmacological perspective. Molecules, 26.","DOI":"10.3390\/molecules26082297"},{"key":"ref_90","first-page":"771","article-title":"A Facile Route towards the Synthesis of 2-(1H-indol-3-yl)-acetamides Using 1, 1-Carbonyldiimidazole","volume":"38","author":"Kanwal","year":"2016","journal-title":"J. Chem. Soc. Pak."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"114194","DOI":"10.1016\/j.ejmech.2022.114194","article-title":"Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis","volume":"232","author":"Jiao","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"ref_92","unstructured":"(2022, August 15). British National Formulary (BNF). Available online: https:\/\/www.bnf.org."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/acr.24180","article-title":"American College of Rheumatology guideline for the management of gout","volume":"72","author":"FitzGerald","year":"2020","journal-title":"Arthritis Care Res."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/19\/6213\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:36:49Z","timestamp":1760143009000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/19\/6213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,21]]},"references-count":93,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["molecules27196213"],"URL":"https:\/\/doi.org\/10.3390\/molecules27196213","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,21]]}}}