{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:57:58Z","timestamp":1787029078835,"version":"build-2736575974"},"reference-count":26,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>N-(Aminoalkyl)azabicyclo[3.2.2]nonanes possess antiplasmodial and antitrypanosomal activity. A series with terminal tetrazole or sulfonamido partial structure was prepared. The structures of all new compounds were confirmed by NMR and IR spectroscopy and by mass spectral data. A single crystal structure analysis enabled the distinction between isomers. The antiprotozoal activities were examined in vitro against strains of Plasmodium falciparum and Trypanosoma brucei rhodesiense (STIB 900). The most active sulfonamide and tetrazole derivates showed activities in the submicromolar range.<\/jats:p>","DOI":"10.3390\/molecules27196217","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T05:33:14Z","timestamp":1663824794000},"page":"6217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Antiprotozoal Activity of Azabicyclo-Nonanes Linked to Tetrazole or Sulfonamide Cores"],"prefix":"10.3390","volume":"27","author":[{"given":"Johanna","family":"Dolensky","sequence":"first","affiliation":[{"name":"Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Schubertstra\u00dfe 1, A-8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Hinteregger","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Schubertstra\u00dfe 1, A-8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Leitner","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Schubertstra\u00dfe 1, A-8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Seebacher","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Schubertstra\u00dfe 1, A-8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Saf","sequence":"additional","affiliation":[{"name":"Institute for Chemistry and Technology of Materials (ICTM), Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9749-2109","authenticated-orcid":false,"given":"Ferdinand","family":"Belaj","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry, Institute of Chemistry, University of Graz, Schubertstra\u00dfe 1, A-8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3122-1941","authenticated-orcid":false,"given":"Pascal","family":"M\u00e4ser","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Kreuzstra\u00dfe 2, CH-4123 Allschwil, Switzerland"},{"name":"Swiss Tropical and Public Health Institute, University of Basel, Petersplatz 1, CH-4003 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-7302","authenticated-orcid":false,"given":"Marcel","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Kreuzstra\u00dfe 2, CH-4123 Allschwil, Switzerland"},{"name":"Swiss Tropical and Public Health Institute, University of Basel, Petersplatz 1, CH-4003 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7174-6673","authenticated-orcid":false,"given":"Robert","family":"Weis","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Schubertstra\u00dfe 1, A-8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"ref_1","unstructured":"WHO (2021). 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