{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:44:47Z","timestamp":1760244287596,"version":"build-2065373602"},"reference-count":64,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"INSERM, France, and Semmelweis University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Benzylamine is a natural molecule present in food and edible plants, capable of activating hexose uptake and inhibiting lipolysis in human fat cells. These effects are dependent on its oxidation by amine oxidases present in adipocytes, and on the subsequent hydrogen peroxide production, known to exhibit insulin-like actions. Virtually, other substrates interacting with such hydrogen peroxide-releasing enzymes potentially can modulate lipid accumulation in adipose tissue. Inhibition of such enzymes has also been reported to influence lipid deposition. We have therefore studied in human adipocytes the lipolytic and lipogenic activities of pharmacological entities designed to interact with amine oxidases highly expressed in this cell type: the semicarbazide-sensitive amine oxidase (SSAO also known as PrAO or VAP-1) and the monoamine oxidases (MAO). The results showed that SZV-2016 and SZV-2017 behaved as better substrates than benzylamine, releasing hydrogen peroxide once oxidized, and reproduced or even exceeded its insulin-like metabolic effects in fat cells. Additionally, several novel SSAO inhibitors, such as SZV-2007 and SZV-1398, have been evidenced and shown to inhibit benzylamine metabolic actions. Taken as a whole, our findings reinforce the list of molecules that influence the regulation of triacylglycerol assembly\/breakdown, at least in vitro in human adipocytes. The novel compounds deserve deeper investigation of their mechanisms of interaction with SSAO or MAO, and constitute potential candidates for therapeutic use in obesity and diabetes.<\/jats:p>","DOI":"10.3390\/molecules27196224","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T05:33:14Z","timestamp":1663824794000},"page":"6224","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Chemical Structures Interacting with Amine Oxidases on Glucose, Lipid and Hydrogen Peroxide Handling by Human Adipocytes"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7765-6647","authenticated-orcid":false,"given":"Christian","family":"Carp\u00e9n\u00e9","sequence":"first","affiliation":[{"name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires, INSERM UMR1297, 31432 Toulouse, France"},{"name":"Team Dinamix, Institute of Metabolic and Cardiovascular Diseases (I2MC), Paul Sabatier University, 31432 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9n\u00e9lope","family":"Viana","sequence":"additional","affiliation":[{"name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires, INSERM UMR1297, 31432 Toulouse, France"},{"name":"Team Dinamix, Institute of Metabolic and Cardiovascular Diseases (I2MC), Paul Sabatier University, 31432 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsa","family":"Iffi\u00fa-Soltesz","sequence":"additional","affiliation":[{"name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires, INSERM UMR1297, 31432 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e1l","family":"Tapolcs\u00e1nyi","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Semmelweis University, H-1092 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna \u00c1gota","family":"F\u00f6ldi","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Semmelweis University, H-1092 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"M\u00e1tyus","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Semmelweis University, H-1092 Budapest, Hungary"},{"name":"E-Group ICT SOFTWARE, H-1027 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5445-8357","authenticated-orcid":false,"given":"Petra","family":"Dunkel","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Semmelweis University, H-1092 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1126\/science.1529341","article-title":"A 90-kilodalton endothelial cell molecule mediating lymphocyte binding in humans","volume":"257","author":"Salmi","year":"1992","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1089\/ars.2017.7418","article-title":"Vascular Adhesion Protein-1: A cell surface amine oxidase in translation","volume":"30","author":"Salmi","year":"2019","journal-title":"Antioxid. 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