{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:40:22Z","timestamp":1791747622017,"version":"4.3.4"},"reference-count":144,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Benem\u00e9rita Universidad Aut\u00f3noma de Puebla"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cancer is a global public health problem that is related to different environmental and lifestyle factors. Although the combination of screening, prevention, and treatment of cancer has resulted in increased patient survival, conventional treatments sometimes have therapeutic limitations such as resistance to drugs or severe side effects. Oriental culture includes herbal medicine as a complementary therapy in combination with chemotherapy or radiotherapy. This study aimed to identify the bioactive ingredients in Kalanchoe pinnata, a succulent herb with ethnomedical applications for several diseases, including cancer, and reveal its anticancer mechanisms through a molecular approach. The herb contains gallic acid, caffeic acid, coumaric acid, quercetin, quercitrin, isorhamnetin, kaempferol, bersaldegenin, bryophyllin a, bryophyllin c, bryophynol, bryophyllol and bryophollone, stigmasterol, campesterol, and other elements. Its phytochemicals participate in the regulation of proliferation, apoptosis, cell migration, angiogenesis, metastasis, oxidative stress, and autophagy. They have the potential to act as epigenetic drugs by reverting the acquired epigenetic changes associated with tumor resistance to therapy\u2014such as the promoter methylation of suppressor genes, inhibition of DNMT1 and DNMT3b activity, and HDAC regulation\u2014through methylation, thereby regulating the expression of genes involved in the PI3K\/Akt\/mTOR, Nrf2\/Keap1, MEK\/ERK, and Wnt\/\u03b2-catenin pathways. All of the data support the use of K. pinnata as an adjuvant in cancer treatment.<\/jats:p>","DOI":"10.3390\/molecules27196425","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T23:09:29Z","timestamp":1664492969000},"page":"6425","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Potential of Kalanchoe pinnata as a Cancer Treatment Adjuvant and an Epigenetic Regulator"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-2118","authenticated-orcid":false,"given":"Marta Elena","family":"Hern\u00e1ndez-Caballero","sequence":"first","affiliation":[{"name":"Facultad de Medicina, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Biomedicina, 13 sur 2702 Col. Volcanes, Puebla C.P. 72410, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Alfredo","family":"Sierra-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Salvador D\u00edaz Mir\u00f3n Esq. Plan de San Luis S\/N, Miguel Hidalgo, Casco de Santo Tomas, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Villalobos-Valencia","sequence":"additional","affiliation":[{"name":"UMAE Hospital de Oncolog\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauht\u00e9moc 330, Col. Doctores, Cd M\u00e9xico C.P. 06725, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Sese\u00f1a-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Biomedicina, 13 sur 2702 Col. Volcanes, Puebla C.P. 72410, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nm1087","article-title":"Cancer genes and the pathways they control","volume":"10","author":"Vogelstein","year":"2004","journal-title":"Nat. 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