{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:11:13Z","timestamp":1783476673146,"version":"3.55.0"},"reference-count":42,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21871227"],"award-info":[{"award-number":["21871227"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["XCL-085"],"award-info":[{"award-number":["XCL-085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Six Talent Peak Projects in Jiangsu Province","award":["21871227"],"award-info":[{"award-number":["21871227"]}]},{"name":"Six Talent Peak Projects in Jiangsu Province","award":["XCL-085"],"award-info":[{"award-number":["XCL-085"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Theranostics play an important role in cancer treatment due to its realized real-time tracking of therapeutic efficacy in situ. In this work, we have designed and synthesized a terpyridine-modified pillar [5]arenes (TP5). By the coordination of terpyridine and Zn2+, the complex TP5\/Zn was obtained. Then, supramolecular amphiphile can be constructed by using host\u2013guest complexation between a polyethylene glycol contained guest (PM) and TP5\/Zn. Combining the fluorescence properties from the terpyridine group and the amphiphilicity from the system, the obtained TP5\/Zn\/PM can further be self-assembled into fluorescent particles with diameters of about 150 nm in water. The obtained particles can effectively load anti-cancer drugs and realize living cell imaging and a precise release of the drugs.<\/jats:p>","DOI":"10.3390\/molecules27196428","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T23:09:29Z","timestamp":1664492969000},"page":"6428","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Nano-Theranostics Constructed from Terpyridine-Modified Pillar [5]arene-Based Supramolecular Amphiphile and Its Application in Both Cell Imaging and Cancer Therapy"],"prefix":"10.3390","volume":"27","author":[{"given":"Youjun","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225001, China"},{"name":"School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longtao","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225001, China"},{"name":"School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Han","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Guo","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5566-4822","authenticated-orcid":false,"given":"Yong","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.1021\/ja711260m","article-title":"para-Bridged Symmetrical Pillar [5]arenes: Their Lewis Acid Catalyzed Synthesis and Host\u2013Guest Property","volume":"130","author":"Ogoshi","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9721","DOI":"10.1002\/anie.200904765","article-title":"A Facile and Efficient Preparation of Pillararenes and a Pillarquinone","volume":"48","author":"Cao","year":"2009","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1016\/j.cclet.2021.04.046","article-title":"Rim-differentiated pillar [5]arenes","volume":"32","author":"Wu","year":"2021","journal-title":"Chin. Chem. Lett."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9590","DOI":"10.1039\/D0TA03169K","article-title":"A highly efficient artificial light-harvesting system with two-step sequential energy transfer based on supramolecular self-assembly","volume":"8","author":"Sun","year":"2020","journal-title":"J. Mater. Chem. A"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1021\/acs.inorgchem.0c03645","article-title":"Pillar [5]arene-Based 3D Hybrid Supramolecular Polymer for Green Catalysis in Water","volume":"60","author":"Cai","year":"2021","journal-title":"Inorg. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1039\/C9CC08728A","article-title":"Stabilization of Grignard reagents by a pillar [5]arene host-Schlenk equilibria and Grignard reactions","volume":"56","author":"Shen","year":"2020","journal-title":"Chem. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"11296","DOI":"10.1002\/anie.201904183","article-title":"Formation of a Pillar [5]arene-Based Two-Dimensional Poly-Pseudo-Rotaxane: Threading and Crosslinking by the Same Guest Molecules","volume":"58","author":"Lee","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"11915","DOI":"10.1021\/acs.inorgchem.0c01752","article-title":"Pillar [5]arene-Based [2]Rotaxane: Synthesis, Characterization, and Application in a Coupling Reaction","volume":"59","author":"Guo","year":"2020","journal-title":"Inorg. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"10155","DOI":"10.1039\/D0CC04375C","article-title":"Oxacalix [4]arene-bridged pillar [5]arene dimers: Syntheses, planar chirality and construction of chiral rotaxanes","volume":"56","author":"Wan","year":"2020","journal-title":"Chem. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5302","DOI":"10.1002\/anie.201900217","article-title":"pH-Responsive Pillar [6]arene-based Water-Soluble Supramolecular Hexagonal Boxes","volume":"58","author":"Hadar","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.cclet.2020.11.030","article-title":"Hybrid vesicles of pillar [5]arene\/silica: Host-guest complexation and application in pH-triggered release","volume":"32","author":"Hou","year":"2021","journal-title":"Chin. Chem. Lett."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1039\/D1NJ05461A","article-title":"[1]Rotaxanes based on phosphorylated pillar [5]arenes","volume":"46","author":"Nazarova","year":"2022","journal-title":"New J. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"11976","DOI":"10.1021\/jacs.1c07006","article-title":"Pyridine-Conjugated Pillar [5]arene: From Molecular Crystals of Blue Luminescence to Red-Emissive Coordination Nanocrystals","volume":"143","author":"Lou","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1021\/jacs.0c11833","article-title":"Guest-Binding-Induced Interhetero Hosts Charge Transfer Crystallization: Selective Coloration of Commonly Used Organic Solvents","volume":"143","author":"Mi","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"ref_15","first-page":"371","article-title":"Guest induced morphology transitions of star shaped pillar [5]arene trimer via endo host-guest and \u201cexo-wall\u201d electron-transfer interactions","volume":"32","author":"Ali","year":"2021","journal-title":"Chem. Lett."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1039\/D0QM00547A","article-title":"Morphology, structure and cytotoxicity of dye-loaded lipid nanoparticles based on monoamine pillar [5]arenes","volume":"4","author":"Yakimova","year":"2020","journal-title":"Mater. Chem. Front."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"108073","DOI":"10.1016\/j.dyepig.2019.108073","article-title":"A pillar [5]arene-based and OH\u2212 dependent dual-channel supramolecular chemosensor for recyclable CO2 gas detection: High sensitive and selective off-on-off response","volume":"174","author":"Zhu","year":"2020","journal-title":"Dye. Pigment."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cclet.2020.03.058","article-title":"CO2 and photo-controlled reversible conversion of supramolecular assemblies based on water soluble pillar [5]arene and coumarin-containing guest","volume":"32","author":"Cao","year":"2021","journal-title":"Chin. Chem. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"10642","DOI":"10.1039\/D0CC04149A","article-title":"Tumor microenvironment responsive supramolecular glyco-nanovesicles based on diselenium-bridged pillar [5]arene dimer for targeted chemotherapy","volume":"56","author":"Wang","year":"2020","journal-title":"Chem. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"15665","DOI":"10.1002\/anie.201906740","article-title":"Pillar [5]arene-Stabilized Silver Nanoclusters: Extraordinary Stability and Luminescence Enhancement Induced by Host-Guest Interactions","volume":"58","author":"Muhammed","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.cclet.2020.08.001","article-title":"Ultra-stable and multistimuli-responsive nanoparticles coated with zwitterionic pillar[n]arene for enhanced cellular uptake","volume":"32","author":"Jiao","year":"2021","journal-title":"Chin. Chem. Lett."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1039\/C9QM00428A","article-title":"Stimuli-responsive nanocarriers constructed from pillar[n]arene-based supra-amphiphiles","volume":"3","author":"Xiao","year":"2019","journal-title":"Mater. Chem. Front."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1038\/s41467-019-10385-9","article-title":"Supramolecular peptide constructed by molecular Lego allowing programmable self-assembly for photodynamic therapy","volume":"10","author":"Zhu","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"10328","DOI":"10.1039\/C8CC05560B","article-title":"Multifunctional supramolecular vesicles for combined photothermal\/photodynamic\/hypoxia-activated chemotherapy","volume":"54","author":"Wang","year":"2018","journal-title":"Chem. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1021\/acsmacrolett.0c00714","article-title":"Cationic Water-Soluble Pillar [5]arene-Modified Cu2\u2013xSe Nanoparticles: Supramolecular Trap for ATP and Application in Targeted Photothermal Therapy in the NIR-II Window","volume":"9","author":"Cen","year":"2020","journal-title":"ACS Macro Lett."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1039\/C9TB00555B","article-title":"Dual acid-responsive bola-type supramolecular vesicles for efficient intracellular anticancer drug delivery","volume":"7","author":"Sun","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1039\/C8CS00030A","article-title":"Terpyridine-based metallosupramolecular constructs: Tailored monomers to precise 2D-motifs and 3D-metallocages","volume":"47","author":"Chakraborty","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1039\/C4DT02728K","article-title":"Synthesis, structure and photophysical properties of a highly luminescent terpyridine-diphenylacetylene hybrid fluorophore and its metal complexes","volume":"44","author":"Ghosh","year":"2015","journal-title":"Dalton Trans."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8243","DOI":"10.1039\/D0DT03989F","article-title":"Copper chloride complexes with substituted 4\u2032-phenyl-terpyridine ligands: Synthesis, characterization, antiproliferative activities and DNA interactions","volume":"50","author":"Li","year":"2021","journal-title":"Dalton Trans."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1126\/science.8342038","article-title":"Transition Metals in Control of Gene Expression","volume":"261","author":"Ohalloran","year":"1993","journal-title":"Science"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.271.5252.1081","article-title":"The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc","volume":"271","author":"Berg","year":"1996","journal-title":"Science"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1021\/acsami.8b19667","article-title":"Phase-Change Material Packaged within Hollow Copper Sulfide Nanoparticles Carrying Doxorubicin and Chlorin e6 for Fluorescence-Guided Trimodal Therapy of Cancer","volume":"11","author":"Li","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0034-5687(81)90011-6","article-title":"Effect of CO2 and lactic acid on intracellular pH of ascites tumor cells","volume":"45","author":"Albers","year":"1981","journal-title":"Resp. Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12951-021-01237-0","article-title":"GOx-assisted synthesis of pillar [5]arene based supramolecular polymeric nanoparticles for targeted\/synergistic chemo-chemodynamic cancer therapy","volume":"20","author":"Wang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"37466","DOI":"10.1021\/acsami.1c07106","article-title":"Orthogonal Design of a Water-Soluble meso-Tetraphenylethene-Functionalized Pillar [5]arene with Aggregation-Induced Emission Property and Its Therapeutic Application","volume":"13","author":"Tian","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"11443","DOI":"10.1039\/D1CC04672A","article-title":"Luminescent lanthanide\u2013macrocycle supramolecular assembly","volume":"57","author":"Zhou","year":"2021","journal-title":"Chem. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"7627","DOI":"10.1021\/acs.inorgchem.1c00962","article-title":"Platinum(II) Metallatriangle: Construction, Coassembly with Polypeptide, and Application in Combined Cancer Photodynamic and Chemotherapy","volume":"60","author":"Zhang","year":"2021","journal-title":"Inorg. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1039\/D1CC05584D","article-title":"Controlled release of drug molecules by pillararene-modified nanosystems","volume":"58","author":"Yang","year":"2022","journal-title":"Chem. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"116649","DOI":"10.1016\/j.bmc.2022.116649","article-title":"Dual-responsive drug release and fluorescence imaging based on disulfide-pillar [4]arene aggregate in cancer cells","volume":"57","author":"Tang","year":"2022","journal-title":"Bioorgan. Med. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e202203786","DOI":"10.1002\/anie.202203786","article-title":"A Hybrid Supramolecular Polymeric Nanomedicine for Cascade-Amplified Synergetic Cancer Therapy","volume":"61","author":"Yang","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"9039","DOI":"10.1039\/c3ra46681g","article-title":"A water-soluble pillar[6]arene: Synthesis, host\u2013guest chemistry, controllable self-assembly, and application in controlled release","volume":"4","author":"Yao","year":"2014","journal-title":"RSC Adv."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1039\/C5CC00535C","article-title":"Formation of fluorescent supramolecular polymeric assemblies via orthogonal pillar[5]arene-based molecular recognition and metal ion coordination","volume":"51","author":"Shi","year":"2015","journal-title":"Chem. Commun."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/19\/6428\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:41:49Z","timestamp":1760143309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/19\/6428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":42,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["molecules27196428"],"URL":"https:\/\/doi.org\/10.3390\/molecules27196428","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,29]]}}}