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For making such a hybrid system, NA was intercalated into LDH through a coprecipitation technique and then coated with Eudragit\u00ae S100 to make the final drug delivery system called Eudragit\u00ae S100-coated NA-LDH. The as-made drug delivery system not only improved the NA release profile but also exhibited good bio-compatibility as tested on L929 cells. Such an inorganic\u2013organic nanohybrid drug delivery agent is expected to reduce the undesirable side effects associated with NA and hopefully improve the pharmacological effects without inducing any undesirable toxicity.<\/jats:p>","DOI":"10.3390\/molecules27196439","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T23:09:29Z","timestamp":1664492969000},"page":"6439","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["pH-Responsive Inorganic\/Organic Nanohybrids System for Controlled Nicotinic Acid Drug Release"],"prefix":"10.3390","volume":"27","author":[{"given":"Seungjin","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Korea"},{"name":"Intelligent Nanohybrid Materials Laboratory (INML), Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyan","family":"Piao","sequence":"additional","affiliation":[{"name":"Intelligent Nanohybrid Materials Laboratory (INML), Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-0563","authenticated-orcid":false,"given":"N. 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