{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:55:20Z","timestamp":1792292120859,"version":"4.4.0"},"reference-count":250,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with improved bioavailability. Polydatin possesses potential biological activities predominantly through the modulation of pivotal signaling pathways involved in inflammation, oxidative stress, and apoptosis. Various imperative biological activities have been suggested for polydatin towards promising therapeutic effects, including anticancer, cardioprotective, anti-diabetic, gastroprotective, hepatoprotective, neuroprotective, anti-microbial, as well as health-promoting roles on the renal system, the respiratory system, rheumatoid diseases, the skeletal system, and women\u2019s health. In the present study, the therapeutic targets, biological activities, pharmacological mechanisms, and health benefits of polydatin are reviewed to provide new insights to researchers. The need to develop further clinical trials and novel delivery systems of polydatin is also considered to reveal new insights to researchers.<\/jats:p>","DOI":"10.3390\/molecules27196474","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T04:00:02Z","timestamp":1665288002000},"page":"6474","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":160,"title":["Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits"],"prefix":"10.3390","volume":"27","author":[{"given":"Ahmad","family":"Karami","sequence":"first","affiliation":[{"name":"Student Research Committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 6714415153, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8265-8284","authenticated-orcid":false,"given":"Sajad","family":"Fakhri","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Kooshki","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 6714415153, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroon","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/s41419-018-0635-5","article-title":"A new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo","volume":"9","author":"Mele","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1016\/j.bbadis.2016.09.003","article-title":"Polydatin protects cardiomyocytes against myocardial infarction injury by activating Sirt3","volume":"1863","author":"Zhang","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s11101-018-9574-0","article-title":"Recent advances in chemistry, therapeutic properties and sources of polydatin","volume":"17","author":"Baran","year":"2018","journal-title":"Phytochem. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jchromb.2019.04.005","article-title":"Comprehensive metabolism study of polydatin in rat plasma and urine using ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry","volume":"1117","author":"Mei","year":"2019","journal-title":"J. Chromatogr. B"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejphar.2018.10.039","article-title":"The protective mechanisms of polydatin in cerebral ischemia","volume":"842","author":"Tan","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.jep.2013.05.007","article-title":"Botany, phytochemistry, pharmacology, and potential application of Polygonum cuspidatum Sieb. et Zucc.: A review","volume":"148","author":"Peng","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Negrea, B.-M., Stoilov-Linu, V., Pop, C.-E., De\u00e1k, G., Cr\u0103ciun, N., and F\u0103g\u0103ra\u0219, M.M. (2022). Expansion of the Invasive Plant Species Reynoutria japonica Houtt in the Upper Bistri\u021ba Mountain River Basin with a Calculus on the Productive Potential of a Mountain Meadow. Sustainability, 14.","DOI":"10.3390\/su14095737"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3389\/fphar.2018.00557","article-title":"Berberine: Botanical occurrence, traditional uses, extraction methods, and relevance in cardiovascular, metabolic, hepatic, and renal disorders","volume":"9","author":"Neag","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00204-017-2073-z","article-title":"Protective effects of the resveratrol analog piceid in dopaminergic SH-SY5Y cells","volume":"92","author":"Potdar","year":"2018","journal-title":"Arch. Toxicol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3109\/13880209.2013.792849","article-title":"Polydatin: A review of pharmacology and pharmacokinetics","volume":"51","author":"Du","year":"2013","journal-title":"Pharm. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s10753-011-9310-z","article-title":"Anti-inflammatory effect of resveratrol and polydatin by in vitro IL-17 modulation","volume":"35","author":"Lanzilli","year":"2012","journal-title":"Inflammation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/odi.13518","article-title":"New intriguing possibility for prevention of coronavirus pneumonitis: Natural purified polyphenols","volume":"28","author":"Muzio","year":"2020","journal-title":"Oral Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"857879","DOI":"10.3389\/fnut.2022.857879","article-title":"Polydatin, A Glycoside of Resveratrol, Is Better Than Resveratrol in Alleviating Non-alcoholic Fatty Liver Disease in Mice Fed a High-Fructose Diet","volume":"9","author":"Zhao","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1042\/bj2480953","article-title":"Hydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans","volume":"248","author":"Bokkenheuser","year":"1987","journal-title":"Biochem. J."},{"key":"ref_15","first-page":"905215","article-title":"Bioavailability of dietary polyphenols and gut microbiota metabolism: Antimicrobial properties","volume":"2015","author":"Villar","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1002\/jsfa.6900","article-title":"Deglycosylation of isoflavone C-glycosides by newly isolated human intestinal bacteria","volume":"95","author":"Kim","year":"2015","journal-title":"J. Sci. Food Agric."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1021\/jf9900884","article-title":"Determination of stilbenes (trans-astringin, cis-and trans-piceid, and cis-and trans-resveratrol) in Portuguese wines","volume":"47","author":"Teissedre","year":"1999","journal-title":"J. Agric. Food Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jpha.2012.12.001","article-title":"A simple method for the isolation and purification of resveratrol from Polygonum cuspidatum","volume":"3","author":"Wang","year":"2013","journal-title":"J. Pharm. Anal."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1021\/jf000745o","article-title":"Method for the quantitative extraction of resveratrol and piceid isomers in grape berry skins. Effect of powdery mildew on the stilbene content","volume":"49","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Fakhri, S., Gravandi, M.M., Abdian, S.A.-O., Akkol, E.A.-O., Farzaei, M.A.-O., and Sobarzo-S\u00e1nchez, E.A.-O. (2021). The Neuroprotective Role of Polydatin: Neuropharmacological Mechanisms, Molecular Targets, Therapeutic Potentials, and Clinical Perspective. Molecules, 26.","DOI":"10.3390\/molecules26195985"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-019-1164-5","article-title":"Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation","volume":"38","author":"Mele","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1039\/C6FO01842D","article-title":"trans-Polydatin protects the mouse heart against ischemia\/reperfusion injury via inhibition of the renin\u2013angiotensin system (RAS) and Rho kinase (ROCK) activity","volume":"8","author":"Ming","year":"2017","journal-title":"Food Funct."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.freeradbiomed.2017.03.003","article-title":"Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys","volume":"106","author":"Gong","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.lfs.2018.11.053","article-title":"Polydatin attenuates spinal cord injury in rats by inhibiting oxidative stress and microglia apoptosis via Nrf2\/HO-1 pathway","volume":"217","author":"Lv","year":"2019","journal-title":"Life Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.redox.2018.07.002","article-title":"Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1\/Nrf2 pathway","volume":"18","author":"Zhao","year":"2018","journal-title":"Redox Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41374-019-0191-3","article-title":"Polydatin mediates Parkin-dependent mitophagy and protects against mitochondria-dependent apoptosis in acute respiratory distress syndrome","volume":"99","author":"Li","year":"2019","journal-title":"Lab. Investig."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"965961","DOI":"10.1155\/2015\/965961","article-title":"Polydatin alleviates small intestine injury during hemorrhagic shock as a SIRT1 activator","volume":"2015","author":"Zeng","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/aps.2016.123","article-title":"Polydatin ameliorates Staphylococcus aureus-induced mastitis in mice via inhibiting TLR2-mediated activation of the p38 MAPK\/NF-\u03baB pathway","volume":"38","author":"Jiang","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Masodsai, K., Lin, Y.Y., Chaunchaiyakul, R., Su, C.T., Lee, S.D., and Yang, A.L. (2019). Twelve-Week Protocatechuic Acid Administration Improves Insulin-Induced and Insulin-Like Growth Factor-1-Induced Vasorelaxation and Antioxidant Activities in Aging Spontaneously Hypertensive Rats. Nutrients, 11.","DOI":"10.3390\/nu11030699"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"117244","DOI":"10.1016\/j.lfs.2019.117244","article-title":"Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses","volume":"243","author":"Kang","year":"2020","journal-title":"Life Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"103720","DOI":"10.1016\/j.micpath.2019.103720","article-title":"Protective effects of polydatin on LPS-induced endometritis in mice","volume":"137","author":"Li","year":"2019","journal-title":"Microb. Pathog."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2174\/1570159X18666200611144825","article-title":"Protective Effects of Polydatin Against Dementia-Related Disorders","volume":"19","author":"Tang","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"ref_33","first-page":"1","article-title":"Polydatin protects neuronal cells from hydrogen peroxide damage by activating CREB\/Ngb signaling","volume":"25","author":"Zhang","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"110308","DOI":"10.1016\/j.biopha.2020.110308","article-title":"Polydatin for treating atherosclerotic diseases: A functional and mechanistic overview","volume":"128","author":"Wu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"117756","DOI":"10.1016\/j.lfs.2020.117756","article-title":"Insights into pharmacological mechanisms of polydatin in targeting risk factors-mediated atherosclerosis","volume":"254","author":"Ahmad","year":"2020","journal-title":"Life Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"103485","DOI":"10.1016\/j.bioorg.2019.103485","article-title":"Protective effects of polydatin on multiple organ ischemia-reperfusion injury","volume":"94","author":"Sun","year":"2019","journal-title":"Bioorganic Chem."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Liu, C., Wang, W., Zhang, K., Liu, Q., Ma, T., Tan, L., and Ma, L. (2022). Protective Effects of Polydatin from Grapes and Reynoutria japonica Houtt. on Damaged Macrophages Treated with Acetaminophen. Nutrients, 14.","DOI":"10.3390\/nu14102077"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Salem, M.A., Serag, A., El-Seedi, H.R., Hamdan, D.I., Ezzat, S.M., and Zayed, A. (2021). Identification and analysis of toxic phytochemicals. Phytochemistry, the Military and Health, Elsevier.","DOI":"10.1016\/B978-0-12-821556-2.00015-3"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.1002\/jcp.26479","article-title":"The multifaceted link between inflammation and human diseases","volume":"233","author":"Rajendran","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/wsbm.1331","article-title":"Signaling via the NF\u03baB system","volume":"8","author":"Mitchell","year":"2016","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1002\/cmdc.202000996","article-title":"The Role of Chronic Inflammation in Various Diseases and Anti-inflammatory Therapies Containing Natural Products","volume":"16","author":"Wang","year":"2021","journal-title":"ChemMedChem"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1016\/j.ejmech.2010.02.016","article-title":"Quantitative structure\u2013antioxidant activity relationship of trans-resveratrol oligomers, trans-4,4\u2032-dihydroxystilbene dimer, trans-resveratrol-3-O-glucuronide, glucosides: Trans-piceid, cis-piceid, trans-astringin and trans-resveratrol-4\u2032-O-\u03b2-D-glucopyranoside","volume":"45","author":"Mikulski","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"10137","DOI":"10.1002\/jcb.28297","article-title":"Polydatin suppresses the development of lung inflammation and fibrosis by inhibiting activation of the NACHT domain-, leucine-rich repeat-, and pyd-containing protein 3 inflammasome and the nuclear factor-\u03baB pathway after Mycoplasma pneumoniae infection","volume":"120","author":"Tang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1039\/C6FO01561A","article-title":"Polydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-\u03baB\/NLRP3 inflammasome activation via the AMPK\/SIRT1 pathway","volume":"8","author":"Chen","year":"2017","journal-title":"Food Funct."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Peritore, A.F., D\u2019Amico, R., Cordaro, M., Siracusa, R., Fusco, R., Gugliandolo, E., Genovese, T., Crupi, R., Di Paola, R., and Cuzzocrea, S. (2021). PEA\/Polydatin: Anti-Inflammatory and Antioxidant Approach to Counteract DNBS-Induced Colitis. Antioxidants, 10.","DOI":"10.3390\/antiox10030464"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"7953850","DOI":"10.1155\/2017\/7953850","article-title":"Polydatin Protects Rat Liver against Ethanol-Induced Injury: Involvement of CYP2E1\/ROS\/Nrf2 and TLR4\/NF-\u03baB p65 Pathway","volume":"2017","author":"Huang","year":"2017","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.intimp.2019.02.006","article-title":"Polydatin alleviates traumatic spinal cord injury by reducing microglial inflammation via regulation of iNOS and NLRP3 inflammasome pathway","volume":"70","author":"Lv","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"362158","DOI":"10.1155\/2015\/362158","article-title":"Nephroprotective Effects of Polydatin against Ischemia\/Reperfusion Injury: A Role for the PI3K\/Akt Signal Pathway","volume":"2015","author":"Liu","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/iid3.455","article-title":"Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis","volume":"9","author":"Chen","year":"2021","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fct.2012.10.037","article-title":"Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice","volume":"52","author":"Chen","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10571-018-00646-4","article-title":"MALAT1 Up-Regulator Polydatin Protects Brain Microvascular Integrity and Ameliorates Stroke Through C\/EBP\u03b2\/MALAT1\/CREB\/PGC-1\u03b1\/PPAR\u03b3 Pathway","volume":"39","author":"Ruan","year":"2019","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Shiyu, S., Zhiyu, L., Mao, Y., Lin, B., Lijia, W., Tianbao, Z., Jie, C., and Tingyu, L. (2011). Polydatin up-regulates Clara cell secretory protein to suppress phospholipase A2 of lung induced by LPS in vivo and in vitro. BMC Cell Biol., 12.","DOI":"10.1186\/1471-2121-12-31"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1177\/039463201202500410","article-title":"Polydatin Protects against Lipopolysaccharide-Induced Fulminant Hepatic Failure in D-Galactosamine-Sensitized Mice","volume":"25","author":"Wu","year":"2012","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1007\/s10753-018-0841-4","article-title":"Novel anti-arthritic mechanisms of Polydatin in complete Freund\u2019s adjuvant-induced arthritis in rats: Involvement of IL-6, STAT-3, IL-17, and NF-\u03baB","volume":"41","author":"Kamel","year":"2018","journal-title":"Inflammation"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative Stress: Harms and Benefits for Human Health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S1369-5274(99)80033-2","article-title":"Oxidative stress","volume":"2","author":"Storz","year":"1999","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1039\/C8FO01078A","article-title":"Polydatin protects against acetaminophen-induced hepatotoxicity in mice via anti-oxidative and anti-apoptotic activities","volume":"9","author":"Liu","year":"2018","journal-title":"Food Funct."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"100215","DOI":"10.1016\/j.mtbio.2022.100215","article-title":"Harnessing reactive oxygen\/nitrogen species and inflammation: Nanodrugs for liver injury","volume":"13","author":"Liu","year":"2022","journal-title":"Mater. Today Bio"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"529219","DOI":"10.1155\/2013\/529219","article-title":"Roles Nrf2 Plays in Myeloid Cells and Related Disorders","volume":"2013","author":"Kobayashi","year":"2013","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3389\/fphar.2019.00663","article-title":"Polydatin Attenuates Neuronal Loss via Reducing Neuroinflammation and Oxidative Stress in Rat MCAO Models","volume":"10","author":"Shah","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.brainresbull.2011.09.021","article-title":"Polydatin modulates inflammation by decreasing NF-\u03baB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood\u2013brain barrier permeability for its neuroprotective effect in pMCAO rat brain","volume":"87","author":"Ji","year":"2012","journal-title":"Brain Res. Bull."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.fct.2016.07.032","article-title":"Polydatin ameliorates renal ischemia\/reperfusion injury by decreasing apoptosis and oxidative stress through activating sonic hedgehog signaling pathway","volume":"96","author":"Meng","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.mce.2014.08.014","article-title":"Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-\u03b21 in rat glomerular messangial cells","volume":"399","author":"Huang","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2750695","DOI":"10.1155\/2018\/2750695","article-title":"Polydatin Protects Diabetic Heart against Ischemia-Reperfusion Injury via Notch1\/Hes1-Mediated Activation of Pten\/Akt Signaling","volume":"2018","author":"Yu","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Tan, Y.-Y., Chen, L.-X., Fang, L., and Zhang, Q. (2020). Cardioprotective effects of polydatin against myocardial injury in diabetic rats via inhibition of NADPH oxidase and NF-\u03baB activities. BMC Complement. Med. Ther., 20.","DOI":"10.1186\/s12906-020-03177-y"},{"key":"ref_68","first-page":"471","article-title":"Comparison of Resveratrol and Polydatin on Anti-oxidative Activities","volume":"4","author":"Dan","year":"2010","journal-title":"China Pharm."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"603678","DOI":"10.1155\/2012\/603678","article-title":"Antioxidant Activities of Stilbenoids from Rheum emodi Wall","volume":"2012","author":"Chai","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Zhang, H., Yu, C.-H., Jiang, Y.-P., Peng, C., He, K., Tang, J.-Y., and Xin, H.-L. (2012). Protective effects of polydatin from Polygonum cuspidatum against carbon tetrachloride-induced liver injury in mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0046574"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.phymed.2011.06.023","article-title":"Cardioprotective effect of polydatin against ischemia\/reperfusion injury: Roles of protein kinase C and mito KATP activation","volume":"19","author":"Miao","year":"2011","journal-title":"Phytomedicine"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"7180943","DOI":"10.1155\/2017\/7180943","article-title":"Polydatin Prevents Methylglyoxal-Induced Apoptosis through Reducing Oxidative Stress and Improving Mitochondrial Function in Human Umbilical Vein Endothelial Cells","volume":"2017","author":"Pang","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"110586","DOI":"10.1016\/j.biopha.2020.110586","article-title":"Polydatin attenuates hepatic stellate cell proliferation and liver fibrosis by suppressing sphingosine kinase 1","volume":"130","author":"Lan","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/0140-6736(93)91154-E","article-title":"Apoptosis and disease","volume":"341","author":"Carson","year":"1993","journal-title":"Lancet"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.intimp.2018.09.009","article-title":"Polydatin ameliorates dextran sulfate sodium-induced colitis by decreasing oxidative stress and apoptosis partially via Sonic hedgehog signaling pathway","volume":"64","author":"Lv","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Yu, H.I., Shen, H.C., Chen, S.H., Lim, Y.P., Chuang, H.H., Tai, T.S., Kung, F.P., Lu, C.H., Hou, C.Y., and Lee, Y.R. (2019). Autophagy Modulation in Human Thyroid Cancer Cells following Aloperine Treatment. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20215315"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"11511","DOI":"10.1038\/s41598-020-68880-9","article-title":"Retraction Note: Chondro-protective effects of polydatin in osteoarthritis through its effect on restoring dysregulated autophagy via modulating MAPK, and PI3K\/Akt signaling pathways","volume":"10","author":"Wu","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"8100195","DOI":"10.1155\/2022\/8100195","article-title":"Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury","volume":"2022","author":"Fakhri","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"836","DOI":"10.2174\/1570159X19666210809103346","article-title":"Phytochemicals Targeting Oxidative Stress, Interconnected Neuroinflammatory, and Neuroapoptotic Pathways Following Radiation","volume":"20","author":"Fakhri","year":"2022","journal-title":"Curr. Neuropharmacol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2991\/jegh.k.191008.001","article-title":"Current cancer epidemiology","volume":"9","author":"Mattiuzzi","year":"2019","journal-title":"J. Epidemiol. Glob. Health"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1080\/09168451.2020.1722057","article-title":"Polydatin ameliorates chemotherapy-induced cognitive impairment (chemobrain) by inhibiting oxidative stress, inflammatory response, and apoptosis in rats","volume":"84","author":"Tong","year":"2020","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3892\/ijo.2018.4661","article-title":"From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment","volume":"54","author":"Schirrmacher","year":"2019","journal-title":"Int. J. Oncol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01635581.2019.1673451","article-title":"The effects of anticancer medicinal herbs on vascular endothelial growth factor based on pharmacological aspects: A review study","volume":"73","author":"Fakhri","year":"2021","journal-title":"Nutr. Cancer"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"104895","DOI":"10.1016\/j.phrs.2020.104895","article-title":"The ameliorating effects of anthocyanins on the cross-linked signaling pathways of cancer dysregulated metabolism","volume":"159","author":"Fakhri","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Nouri, Z., Fakhri, S., Nouri, K., Wallace, C.E., Farzaei, M.H., and Bishayee, A. (2020). Targeting multiple signaling pathways in cancer: The rutin therapeutic approach. Cancers, 12.","DOI":"10.3390\/cancers12082276"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.3892\/mmr.2016.4909","article-title":"Polydatin-induced cell apoptosis and cell cycle arrest are potentiated by Janus kinase 2 inhibition in leukemia cells","volume":"13","author":"Cao","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.3389\/fonc.2021.680758","article-title":"Polydatin reduces cardiotoxicity and enhances the anticancer effects of sunitinib by decreasing pro-oxidative stress, pro-inflammatory cytokines, and NLRP3 inflammasome expression","volume":"11","author":"Quagliariello","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_88","first-page":"83","article-title":"Polydatin exerts an antitumor effect through regulating the miR-382\/PD-L1 axis in colorectal cancer","volume":"35","author":"Jin","year":"2020","journal-title":"Cancer Biother. Radiopharm."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"430","DOI":"10.7150\/ijbs.27050","article-title":"Polydatin increases radiosensitivity by inducing apoptosis of stem cells in colorectal cancer","volume":"15","author":"Chen","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/jbt.21779","article-title":"Polydatin induces apoptosis and inhibits growth of acute monocytic leukemia cells","volume":"30","author":"Wang","year":"2016","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e21900","DOI":"10.1002\/jbt.21900","article-title":"Polydatin inhibits cell proliferation and induces apoptosis in laryngeal cancer and HeLa cells via suppression of the PDGF\/AKT signaling pathway","volume":"31","author":"Li","year":"2017","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1002\/jcb.23303","article-title":"Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to polydatin-induced apoptosis in human nasopharyngeal carcinoma CNE cells","volume":"112","author":"Liu","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"279591","DOI":"10.1155\/2015\/279591","article-title":"Resveratrol, acetyl-resveratrol, and polydatin exhibit antigrowth activity against 3D cell aggregates of the SKOV-3 and OVCAR-8 ovarian cancer cell lines","volume":"2015","author":"Hogg","year":"2015","journal-title":"Obstet. Gynecol. Int."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.biopha.2018.09.051","article-title":"Polydatin suppresses proliferation and metastasis of non-small cell lung cancer cells by inhibiting NLRP3 inflammasome activation via NF-\u03baB pathway","volume":"108","author":"Zou","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/01635581.2020.1870705","article-title":"Polydatin-Induced Direct and Bystander Effects in A549 Lung Cancer Cell Line","volume":"74","author":"Verma","year":"2021","journal-title":"Nutr. Cancer"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3892\/ol.2013.1696","article-title":"Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest","volume":"7","author":"Zhang","year":"2014","journal-title":"Oncol. Lett."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"118158","DOI":"10.1016\/j.lfs.2020.118158","article-title":"Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT\/ERK1\/2\/STAT3-SOX2\/Snail signaling pathway","volume":"258","author":"Chen","year":"2020","journal-title":"Life Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"935","DOI":"10.2147\/OTT.S123398","article-title":"Polydatin regulates proliferation, apoptosis and autophagy in multiple myeloma cells through mTOR\/p70s6k pathway","volume":"10","author":"Yang","year":"2017","journal-title":"OncoTargets Ther."},{"key":"ref_99","first-page":"2345","article-title":"Polydatin induces human cervical cancer cell apoptosis via PI3K\/AKT\/mTOR signaling pathway","volume":"42","author":"Pan","year":"2017","journal-title":"Zhongguo Zhong Yao Za Zhi China J. Chin. Mater. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"587218","DOI":"10.3389\/fcell.2021.587218","article-title":"Polydatin Inhibits Cell Viability, Migration, and Invasion Through Suppressing the c-Myc Expression in Human Cervical Cancer","volume":"9","author":"Bai","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Chen, S., Tao, J., Zhong, F., Jiao, Y., Xu, J., Shen, Q., Wang, H., Fan, S., and Zhang, Y. (2017). Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0176501"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1111\/jcmm.14276","article-title":"Targeting the ROS\/PI3K\/AKT\/HIF-1\u03b1\/HK2 axis of breast cancer cells: Combined administration of Polydatin and 2-Deoxy-d-glucose","volume":"23","author":"Zhang","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"17481","DOI":"10.1002\/jcb.29012","article-title":"Polydatin enhances the chemosensitivity of osteosarcoma cells to paclitaxel","volume":"120","author":"Zhao","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s11418-020-01399-5","article-title":"Polydatin induces apoptosis and autophagy via STAT3 signaling in human osteosarcoma MG-63 cells","volume":"74","author":"Jiang","year":"2020","journal-title":"J. Nat. Med."},{"key":"ref_105","first-page":"922","article-title":"Polydatin promotes apoptosis through upregulation the ratio of Bax\/Bcl-2 and inhibits proliferation by attenuating the \u03b2-catenin signaling in human osteosarcoma cells","volume":"8","author":"Xu","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.taap.2019.04.005","article-title":"Polydatin inhibits proliferation and promotes apoptosis of doxorubicin-resistant osteosarcoma through LncRNA TUG1 mediated suppression of Akt signaling","volume":"371","author":"Hu","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e6867","DOI":"10.1590\/1414-431x20176867","article-title":"Polydatin inhibits cell proliferation, invasion and migration, and induces cell apoptosis in hepatocellular carcinoma","volume":"51","author":"Jiao","year":"2018","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_108","first-page":"4505","article-title":"Polydatin inhibits hepatocellular carcinoma via the AKT\/STAT3-FOXO1 signaling pathway Corrigendum in \/10.3892\/ol.2019.10856","volume":"17","author":"Jiang","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Bang, T.-H., Park, B.-S., Kang, H.-M., Kim, J.-H., and Kim, I.-R. (2021). Polydatin, a Glycoside of Resveratrol, Induces Apoptosis and Inhibits Metastasis Oral Squamous Cell Carcinoma Cells In Vitro. Pharmaceuticals, 14.","DOI":"10.3390\/ph14090902"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.fct.2014.07.022","article-title":"Protective effect of polydatin, a natural precursor of resveratrol, against cisplatin-induced toxicity in rats","volume":"72","author":"Ince","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"760","DOI":"10.14336\/AD.2016.0620","article-title":"Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation","volume":"8","author":"Xu","year":"2017","journal-title":"Aging Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2018.08.012","article-title":"Astaxanthin: A mechanistic review on its biological activities and health benefits","volume":"136","author":"Fakhri","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1146\/annurev.bi.46.070177.004341","article-title":"The low-density lipoprotein pathway and its relation to atherosclerosis","volume":"46","author":"Goldstein","year":"1977","journal-title":"Annu. Rev. Biochem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11418-018-1241-7","article-title":"Polydatin protects against acute myocardial infarction-induced cardiac damage by activation of Nrf2\/HO-1 signaling","volume":"73","author":"Chen","year":"2019","journal-title":"J. Nat. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.3892\/ijmm.2016.2554","article-title":"Polydatin inhibits the oxidative stress-induced proliferation of vascular smooth muscle cells by activating the eNOS\/SIRT1 pathway","volume":"37","author":"Ma","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"7776","DOI":"10.3390\/ijms13067776","article-title":"Polydatin attenuates hypoxic pulmonary hypertension and reverses remodeling through protein kinase C mechanisms","volume":"13","author":"Miao","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.phrs.2017.06.014","article-title":"Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury","volume":"123","author":"Gugliandolo","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s10753-019-01153-4","article-title":"Polydatin alleviates septic myocardial injury by promoting SIRT6-mediated autophagy","volume":"43","author":"Yuan","year":"2020","journal-title":"Inflammation"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.fitote.2010.06.023","article-title":"Effects of polydatin on attenuating ventricular remodeling in isoproterenol-induced mouse and pressure-overload rat models","volume":"81","author":"Gao","year":"2010","journal-title":"Fitoterapia"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1055\/s-0035-1545907","article-title":"Cardioprotective effect of polydatin on ventricular remodeling after myocardial infarction in coronary artery ligation rats","volume":"81","author":"Gao","year":"2015","journal-title":"Planta Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1177\/1535370214561958","article-title":"Polydatin prevents angiotensin II-induced cardiac hypertrophy and myocardial superoxide generation","volume":"240","author":"Zhang","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.bbrc.2017.09.151","article-title":"Polydatin ameliorates diabetic cardiomyopathy via Sirt3 activation","volume":"493","author":"Zhang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Pessina, A., Di Vincenzo, M., Maradonna, F., Marchegiani, F., Olivieri, F., Randazzo, B., Gioacchini, G., and Carnevali, O. (2021). Polydatin Beneficial Effects in Zebrafish Larvae Undergoing Multiple Stress Types. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18031116"},{"key":"ref_124","first-page":"4256","article-title":"Effect and mechanism of polydatin on diabetic myocardial hypertrophy in mice","volume":"40","author":"Huang","year":"2015","journal-title":"Zhongguo Zhong Yao Za Zhi China J. Chin. Mater. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.phymed.2008.10.001","article-title":"Lipid-lowering effects of polydatin from Polygonum cuspidatum in hyperlipidemic hamsters","volume":"16","author":"Du","year":"2009","journal-title":"Phytomedicine"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.biopha.2008.06.035","article-title":"Effects of polydatin from Polygonum cuspidatum on lipid profile in hyperlipidemic rabbits","volume":"63","author":"Xing","year":"2009","journal-title":"Biomed. Pharmacother."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"152935","DOI":"10.1016\/j.phymed.2019.152935","article-title":"Polydatin attenuates atherosclerosis in apolipoprotein E-deficient mice: Role of reverse cholesterol transport","volume":"62","author":"Peng","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1142\/S0192415X18500921","article-title":"Polydatin attenuates atherosclerosis in ApoE\u2212\/\u2212 mice through PBEF mediated reduction of cholesterol deposition","volume":"46","author":"Huang","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"153301","DOI":"10.1016\/j.phymed.2020.153301","article-title":"Polydatin alleviates high-fat diet induced atherosclerosis in apolipoprotein E-deficient mice by autophagic restoration","volume":"81","author":"Xiong","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"7196535","DOI":"10.1155\/2019\/7196535","article-title":"Polydatin inhibits adipose tissue inflammation and ameliorates lipid metabolism in high-fat-fed mice","volume":"2019","author":"Zheng","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"729017","DOI":"10.1155\/2015\/729017","article-title":"Polydatin inhibits formation of macrophage-derived foam cells","volume":"2015","author":"Wu","year":"2015","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_132","first-page":"367","article-title":"Polydatin attenuates ischemia\/reperfusion-induced apoptosis in myocardium of the rat","volume":"61","author":"Zhang","year":"2009","journal-title":"Sheng Li Xue Bao"},{"key":"ref_133","first-page":"161","article-title":"Protective effect of polydatin against ischemia\/reperfusion injury in rat heart","volume":"60","author":"Zhang","year":"2008","journal-title":"Sheng Li Xue Bao [Acta Physiol. Sin.]"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1042\/CS20160082","article-title":"Polydatin post-treatment alleviates myocardial ischaemia\/reperfusion injury by promoting autophagic flux","volume":"130","author":"Ling","year":"2016","journal-title":"Clin. Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.freeradbiomed.2013.02.030","article-title":"Polydatin protects cardiac function against burn injury by inhibiting sarcoplasmic reticulum Ca2+ leak by reducing oxidative modification of ryanodine receptors","volume":"60","author":"Jiang","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"111027","DOI":"10.1016\/j.biopha.2020.111027","article-title":"Polydatin mitigates pancreatic \u03b2-cell damage through its antioxidant activity","volume":"133","author":"Yousef","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3892\/mmr.2014.2708","article-title":"Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats","volume":"11","author":"Zhang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.mce.2012.06.008","article-title":"Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting the activation of NF-\u03baB signaling pathway in rat glomerular mesangial cells","volume":"362","author":"Xie","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mce.2016.03.003","article-title":"Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db\/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway","volume":"427","author":"Chen","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12933-015-0325-x","article-title":"Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin\/kexin type 9 (PCSK9)","volume":"15","author":"Wang","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejphar.2014.09.047","article-title":"Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway","volume":"745","author":"Hao","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Wu, Y., Xue, L., Du, W., Huang, B., Tang, C., Liu, C., Qiu, H., and Jiang, Q. (2015). Polydatin restores endothelium-dependent relaxation in rat aorta rings impaired by high glucose: A Novel insight into the PPAR\u03b2-NO signaling pathway. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0126249"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Wang, D., Zhou, Z., and Yuan, L. (2022). Polydatin reverses oxidation low lipoprotein (oxLDL)-induced apoptosis of human umbilical vein endothelial cells via regulating the miR-26a-5p\/BID axis. Eur. J. Histochem., 66.","DOI":"10.4081\/ejh.2022.3505"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s10571-020-00923-1","article-title":"SIRT1 activation by polydatin alleviates oxidative damage and elevates mitochondrial biogenesis in experimental diabetic neuropathy","volume":"41","author":"Bheereddy","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3389\/fphar.2018.00347","article-title":"Root extract of Polygonum cuspidatum Siebold & Zucc. ameliorates DSS-induced ulcerative colitis by affecting NF-kappaB signaling pathway in a mouse model via synergistic effects of polydatin, resveratrol, and emodin","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1055\/s-0030-1250462","article-title":"Polydatin ameliorates DSS-induced colitis in mice through inhibition of nuclear factor-kappaB activation","volume":"77","author":"Yao","year":"2011","journal-title":"Planta Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1080\/14728222.2016.1177023","article-title":"Polydatin ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3 activation-mediated mitochondrial protection","volume":"20","author":"Zeng","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1517\/14728222.2015.1054806","article-title":"Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD2 pathway","volume":"19","author":"Li","year":"2015","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1111\/jcmm.13194","article-title":"Polydatin reduces Staphylococcus aureus lipoteichoic acid-induced injury by attenuating reactive oxygen species generation and TLR 2-NF \u03baB signalling","volume":"21","author":"Zhao","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"8104","DOI":"10.1039\/C8RA08659A","article-title":"Polydatin ameliorates pulmonary fibrosis by suppressing inflammation and the epithelial mesenchymal transition via inhibiting the TGF-\u03b2\/Smad signaling pathway","volume":"9","author":"Qiu","year":"2019","journal-title":"RSC Adv."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"354087","DOI":"10.1155\/2013\/354087","article-title":"Protective effects of polydatin on septic lung injury in mice via upregulation of HO-1","volume":"2013","author":"Li","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Ricordi, C., Pacifici, F., Lanzoni, G., Palamara, A.T., Garaci, E., and Della-Morte, D. (2021). Dietary and protective factors to halt or mitigate progression of autoimmunity, COVID-19 and its associated metabolic diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063134"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jphs.2018.08.007","article-title":"Polydatin alleviated alcoholic liver injury in zebrafish larvae through ameliorating lipid metabolism and oxidative stress","volume":"138","author":"Lai","year":"2018","journal-title":"J. Pharmacol. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.1111\/jcmm.14320","article-title":"The phytochemical polydatin ameliorates non-alcoholic steatohepatitis by restoring lysosomal function and autophagic flux","volume":"23","author":"Chen","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Luo, J.-L., Chen, S., Wang, L., Zhao, X.-H., and Piao, C.-L. (2022). Pharmacological effects of polydatin in the treatment of metabolic diseases: A review. Phytomedicine, 154161.","DOI":"10.1016\/j.phymed.2022.154161"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3892\/mmr.2012.1015","article-title":"Polydatin alleviates non-alcoholic fatty liver disease in rats by inhibiting the expression of TNF-\u03b1 and SREBP-1c","volume":"6","author":"Zhang","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.7150\/ijbs.26086","article-title":"Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice","volume":"14","author":"Li","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2019.01.013","article-title":"Protective effects of polydatin against sulfur mustard-induced hepatic injury","volume":"367","author":"Zhang","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2017.06.017","article-title":"Polydatin protects against carbon tetrachloride-induced liver fibrosis in mice","volume":"629","author":"Zhao","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3748\/wjg.v5.i1.41","article-title":"Protective effects of polydatin against CCl4-induced injury to primarily cultured rat hepatocytes","volume":"5","author":"Huang","year":"1999","journal-title":"World J. Gastroenterol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jss.2015.05.041","article-title":"Polydatin: A new therapeutic agent against multiorgan dysfunction","volume":"198","author":"Zeng","year":"2015","journal-title":"J. Surg. Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.neurol.2020.01.356","article-title":"Epidemiology of neurological diseases in older adults","volume":"176","author":"Dumurgier","year":"2020","journal-title":"Rev. Neurol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1326-10-4","article-title":"Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson\u2019s disease","volume":"10","author":"Chen","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1007\/s12031-020-01546-3","article-title":"Effect of Polydatin on Neurological Function and the Nrf2 Pathway during Intracerebral Hemorrhage","volume":"70","author":"Zhao","year":"2020","journal-title":"J. Mol. Neurosci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1517\/13543784.2013.748033","article-title":"Polydatin\u2013a new mitochondria protector for acute severe hemorrhagic shock treatment","volume":"22","author":"Wang","year":"2013","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"R805","DOI":"10.1152\/ajpregu.00350.2011","article-title":"Polydatin, a natural polyphenol, protects arterial smooth muscle cells against mitochondrial dysfunction and lysosomal destabilization following hemorrhagic shock","volume":"302","author":"Wang","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.phymed.2012.03.002","article-title":"Polydatin protects learning and memory impairments in a rat model of vascular dementia","volume":"19","author":"Li","year":"2012","journal-title":"Phytomedicine"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbrc.2021.03.108","article-title":"Polydatin alleviates traumatic brain injury: Role of inhibiting ferroptosis","volume":"556","author":"Huang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.3389\/fimmu.2018.02527","article-title":"Polydatin prevents lipopolysaccharide (LPS)-induced Parkinson\u2019s disease via regulation of the AKT\/GSK3\u03b2-Nrf2\/NF-\u03baB signaling axis","volume":"9","author":"Huang","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"104671","DOI":"10.1016\/j.neuint.2020.104671","article-title":"Polydatin protects SH-SY5Y in models of Parkinson\u2019s disease by promoting Atg5-mediated but parkin-independent autophagy","volume":"134","author":"Bai","year":"2020","journal-title":"Neurochem. Int."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"104815","DOI":"10.1016\/j.neuint.2020.104815","article-title":"Polydatin alleviates parkinsonism in MPTP-model mice by enhancing glycolysis in dopaminergic neurons","volume":"139","author":"Zhang","year":"2020","journal-title":"Neurochem. Int."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1002\/ptr.7497","article-title":"Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies","volume":"36","author":"Schimith","year":"2022","journal-title":"Phytother. Res. PTR"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.3892\/mmr.2016.5936","article-title":"Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia\/reperfusion injury","volume":"14","author":"Gao","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1016\/j.clnu.2020.09.052","article-title":"Polydatin and its potential protective effect on COVID-19","volume":"39","author":"Bonucci","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.brainres.2006.06.065","article-title":"Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia\u2013reperfusion injury","volume":"1110","author":"Cheng","year":"2006","journal-title":"Brain Res."},{"key":"ref_176","first-page":"133","article-title":"Effect of polydatin on expression of p53 and Notch1 in brain tissue of ischemic cerebrovascular disease","volume":"32","author":"Chen","year":"2018","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_177","first-page":"158","article-title":"Effect of polydatin on expression of CDK5 in the prefrontal cortex of rats with chronic alcoholism","volume":"28","author":"Xu","year":"2012","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi Chin. J. Appl. Physiol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.3892\/mmr.2014.2577","article-title":"Protective effect of polydatin on learning and memory impairments in neonatal rats with hypoxic-ischemic brain injury by up-regulating brain-derived neurotrophic factor","volume":"10","author":"Sun","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"9394150","DOI":"10.1155\/2016\/9394150","article-title":"Polydatin protects bone marrow stem cells against oxidative injury: Involvement of Nrf 2\/ARE pathways","volume":"2016","author":"Chen","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"6687212","DOI":"10.1155\/2021\/6687212","article-title":"Polydatin Attenuates OGD\/R-Induced Neuronal Injury and Spinal Cord Ischemia\/Reperfusion Injury by Protecting Mitochondrial Function via Nrf2\/ARE Signaling Pathway","volume":"2021","author":"Zhan","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1111\/jcmm.15187","article-title":"Polydatin promotes the neuronal differentiation of bone marrow mesenchymal stem cells in vitro and in vivo: Involvement of Nrf2 signalling pathway","volume":"24","author":"Zhan","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_182","first-page":"3038","article-title":"Effect of polydatin on dynamic changes of excitatory amino acids in cerebrospinal fluid of cerebral hemorrhage rats","volume":"35","author":"Liu","year":"2010","journal-title":"Zhongguo Zhong Yao Za Zhi China J. Chin. Mater. Med."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"181","DOI":"10.5650\/jos.62.181","article-title":"Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin","volume":"62","author":"Maoka","year":"2012","journal-title":"J. Oleo Sci."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Wiwanitkit, V. (2021). Polydatin and COVID-19. Clin. Nutr.","DOI":"10.1016\/j.clnu.2021.03.027"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1038\/s41401-020-0475-6","article-title":"Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway","volume":"41","author":"Chen","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"103688","DOI":"10.1016\/j.micpath.2019.103688","article-title":"Polydatin prevents LPS-induced acute kidney injury through inhibiting inflammatory and oxidative responses","volume":"137","author":"Gu","year":"2019","journal-title":"Microb. Pathog."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12967-020-02283-2","article-title":"Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury","volume":"18","author":"Gao","year":"2020","journal-title":"J. Transl. Med."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"6943860","DOI":"10.1155\/2020\/6943860","article-title":"NMR-based metabonomic study reveals intervention effects of polydatin on potassium oxonate-induced hyperuricemia in rats","volume":"2020","author":"Han","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"111549","DOI":"10.1016\/j.biopha.2021.111549","article-title":"SIRT1 provides new pharmacological targets for polydatin through its role as a metabolic sensor","volume":"139","author":"Sun","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1213\/ANE.0000000000000977","article-title":"Polydatin inhibits mitochondrial dysfunction in the renal tubular epithelial cells of a rat model of sepsis-induced acute kidney injury","volume":"121","author":"Gao","year":"2015","journal-title":"Anesth. Analg."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1737185","DOI":"10.1155\/2016\/1737185","article-title":"Polydatin protecting kidneys against hemorrhagic shock-induced mitochondrial dysfunction via SIRT1 activation and p53 deacetylation","volume":"2016","author":"Zeng","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"111079","DOI":"10.1016\/j.mce.2020.111079","article-title":"Polydatin enhances glomerular podocyte autophagy homeostasis by improving Nrf2-dependent antioxidant capacity in fructose-fed rats","volume":"520","author":"Gu","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1111\/jcmm.13230","article-title":"Polydatin alleviated radiation-induced lung injury through activation of Sirt3 and inhibition of epithelial\u2013mesenchymal transition","volume":"21","author":"Cao","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/08923973.2018.1536985","article-title":"Polydatin protects against ovalbumin-induced bronchial asthma in rats; involvement of urocortin and surfactant-D expression","volume":"41","author":"Hanna","year":"2019","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.lfs.2018.08.013","article-title":"Polydatin attenuates reactive oxygen species-induced airway remodeling by promoting Nrf2-mediated antioxidant signaling in asthma mouse model","volume":"218","author":"Zeng","year":"2019","journal-title":"Life Sci."},{"key":"ref_196","first-page":"1","article-title":"Polydatin prevents bleomycin-induced pulmonary fibrosis by inhibiting the TGF-\u03b2\/Smad\/ERK signaling pathway","volume":"20","author":"Liu","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_197","first-page":"41","article-title":"The regulative effects of polydatin on toll-like receptor 4 signal transduction pathway in lung ischemia\/reperfusion injury in rabbits","volume":"25","author":"Jin","year":"2009","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi Chin. J. Appl. Physiol."},{"key":"ref_198","first-page":"62","article-title":"Protective effects of polydatin against lung ischemia\/reperfusion injury and the initial exploration for its mechanism","volume":"24","author":"Wang","year":"2008","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi Chin. J. Appl. Physiol."},{"key":"ref_199","first-page":"8401","article-title":"Polydatin attenuates ipopolysaccharide-induced acute lung injury in rats","volume":"7","author":"Li","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.4187\/respcare.02831","article-title":"Protective effect of polydatin against burn-induced lung injury in rats","volume":"59","author":"Li","year":"2014","journal-title":"Respir. Care"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s10522-021-09915-0","article-title":"Anti-SASP and anti-inflammatory activity of resveratrol, curcumin and \u03b2-caryophyllene association on human endothelial and monocytic cells","volume":"22","author":"Matacchione","year":"2021","journal-title":"Biogerontology"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.intimp.2015.10.027","article-title":"Protective effects of polydatin on lipopolysaccharide-induced acute lung injury through TLR4-MyD88-NF-\u03baB pathway","volume":"29","author":"Jiang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_203","first-page":"239","article-title":"Effect of polydatin on phospholipase A2 in lung tissues in rats with endotoxic shock","volume":"7","author":"Shu","year":"2004","journal-title":"Chin. J. Traumatol."},{"key":"ref_204","first-page":"3528","article-title":"Effects of polydatin on bleomycin-induced pulmonary fibrosis in rats","volume":"36","author":"Zhang","year":"2011","journal-title":"Zhongguo Zhong Yao Za Zhi China J. Chin. Mater. Med."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"765","DOI":"10.21037\/atm-20-4570","article-title":"Polydatin relieves paraquat-induced human MRC-5 fibroblast injury through inhibiting the activation of the NLRP3 inflammasome","volume":"8","author":"Fu","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"5357","DOI":"10.3892\/mmr.2016.5903","article-title":"Effective treatment of polydatin weakens the symptoms of collagen-induced arthritis in mice through its anti-oxidative and anti-inflammatory effects and the activation of MMP-9","volume":"14","author":"Li","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-018-1749-y","article-title":"Polydatin effectively attenuates disease activity in lupus-prone mouse models by blocking ROS-mediated NET formation","volume":"20","author":"Liao","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"105919","DOI":"10.1016\/j.intimp.2019.105919","article-title":"Inhibition of NET formation by polydatin protects against collagen-induced arthritis","volume":"77","author":"Yang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.3892\/mmr.2016.5432","article-title":"Polydatin possesses notable anti-osteoporotic activity via regulation of OPG, RANKL and \u03b2-catenin","volume":"14","author":"Zhou","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s13287-020-01705-8","article-title":"Polydatin improves osteogenic differentiation of human bone mesenchymal stem cells by stimulating TAZ expression via BMP2-Wnt\/\u03b2-catenin signaling pathway","volume":"11","author":"Shen","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"944","DOI":"10.7150\/ijms.24111","article-title":"Polydatin, natural precursor of resveratrol, promotes osteogenic differentiation of mesenchymal stem cells","volume":"15","author":"Posa","year":"2018","journal-title":"Int. J. Med. Sci."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.biopha.2016.04.059","article-title":"Polydatin induces bone marrow stromal cells migration by activation of ERK1\/2","volume":"82","author":"Chen","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1248\/bpb.b18-00522","article-title":"Polydatin regulates the apoptosis and autophagy of fibroblasts obtained from patients with ankylosing spondylitis","volume":"42","author":"Ma","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1111\/jcmm.13848","article-title":"Polydatin suppresses nucleus pulposus cell senescence, promotes matrix homeostasis and attenuates intervertebral disc degeneration in rats","volume":"22","author":"Wang","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_215","first-page":"125","article-title":"Micronized palmitoylethanolamide\/trans-polydatin treatment of endometriosis-related pain: A meta-analysis","volume":"53","author":"Indraccolo","year":"2017","journal-title":"Ann. Dell\u2019istituto Super. Sanita"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejogrb.2010.01.008","article-title":"Effect of palmitoylethanolamide\u2013polydatin combination on chronic pelvic pain associated with endometriosis: Preliminary observations","volume":"150","author":"Indraccolo","year":"2010","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_217","first-page":"382","article-title":"Co-micronized palmitoylethanolamide\/polydatin treatment causes endometriotic lesion regression in a rodent model of surgically induced endometriosis","volume":"7","author":"Fusco","year":"2016","journal-title":"Front. Pharmacol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2147\/IJWH.S204275","article-title":"Effect of ultramicronized-palmitoylethanolamide and co-micronized palmitoylethanolamide\/polydatin on chronic pelvic pain and quality of life in endometriosis patients: An open-label pilot study","volume":"11","author":"Loi","year":"2019","journal-title":"Int. J. Women\u2019s Health"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jss.2009.09.007","article-title":"Hypotensive resuscitation combined with polydatin improve microcirculation and survival in a rabbit model of uncontrolled hemorrhagic shock in pregnancy","volume":"168","author":"Sheng","year":"2011","journal-title":"J. Surg. Res."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"8824150","DOI":"10.1155\/2020\/8824150","article-title":"Exploring the Molecular Mechanism of Qing Guang An Granule in Treating Glaucoma Using Network Pharmacology and Molecular Docking","volume":"2020","author":"Ou","year":"2020","journal-title":"Evid. Based Complement. Altern. Med. Ecam"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"11895","DOI":"10.1038\/s41598-017-12252-3","article-title":"Polydatin inhibits mast cell-mediated allergic inflammation by targeting PI3K\/Akt, MAPK, NF-\u03baB and Nrf2\/HO-1 pathways","volume":"7","author":"Ye","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.taap.2012.08.024","article-title":"Polydatin (PD) inhibits IgE-mediated passive cutaneous anaphylaxis in mice by stabilizing mast cells through modulating Ca2+ mobilization","volume":"264","author":"Yuan","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.3748\/wjg.v19.i25.3980","article-title":"Polydatin attenuated food allergy via store-operated calcium channels in mast cell","volume":"19","author":"Yang","year":"2013","journal-title":"World J. Gastroenterol. WJG"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.taap.2017.06.005","article-title":"Effects of a co-micronized composite containing palmitoylethanolamide and polydatin in an experimental model of benign prostatic hyperplasia","volume":"329","author":"Cordaro","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1744806919900717","DOI":"10.1177\/1744806919900717","article-title":"Anxiolytic effects of polydatin through the blockade of neuroinflammation in a chronic pain mouse model","volume":"16","author":"Guan","year":"2020","journal-title":"Mol. Pain"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"108894","DOI":"10.1016\/j.cbi.2019.108894","article-title":"Polydatin attenuates orbital oxidative stress in Graves\u2019 orbitopathy through the NRF2 pathway","volume":"315","author":"Li","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1039\/C7FO01555K","article-title":"Polydatin inhibits the IL-1\u03b2-induced inflammatory response in human osteoarthritic chondrocytes by activating the Nrf2 signaling pathway and ameliorates murine osteoarthritis","volume":"9","author":"Tang","year":"2018","journal-title":"Food Funct."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.1039\/C6FO01057A","article-title":"Polydatin attenuates d-galactose-induced liver and brain damage through its anti-oxidative, anti-inflammatory and anti-apoptotic effects in mice","volume":"7","author":"Xu","year":"2016","journal-title":"Food Funct."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s10753-012-9516-8","article-title":"Polydatin, a natural precursor of resveratrol, induces \u03b2-defensin production and reduces inflammatory response","volume":"36","author":"Ravagnan","year":"2013","journal-title":"Inflammation"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"9136249","DOI":"10.1155\/2019\/9136249","article-title":"Prophylactic dermatologic treatment of afatinib-induced skin toxicities in patients with metastatic lung cancer: A pilot study","volume":"2019","author":"Fuggetta","year":"2019","journal-title":"Scientifica"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"9828397","DOI":"10.1155\/2019\/9828397","article-title":"Micronized palmitoylethanolamide-polydatin reduces the painful symptomatology in patients with interstitial cystitis\/bladder pain syndrome","volume":"2019","author":"Cervigni","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1002\/ptr.7177","article-title":"Polydatin protects Schwann cells from methylglyoxal induced cytotoxicity and promotes crushed sciatic nerves regeneration of diabetic rats","volume":"35","author":"Chen","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_233","first-page":"453","article-title":"Administration of micronized palmitoylethanolamide (PEA)-transpolydatin in the treatment of chronic pelvic pain in women affected by endometriosis: Preliminary results","volume":"65","author":"Soave","year":"2013","journal-title":"Minerva Ginecol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/apt.13958","article-title":"Randomised clinical trial: The analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome","volume":"45","author":"Cremon","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_235","first-page":"405","article-title":"Polydatin administration improves serum biochemical parameters and oxidative stress markers during chronic alcoholism: A pilot study","volume":"29","author":"Pace","year":"2015","journal-title":"Vivo"},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Biswas, P., Dellanoce, C., Vezzoli, A., Mrakic-Sposta, S., Malnati, M., Beretta, A., and Accinni, R. (2020). Antioxidant Activity with Increased Endogenous Levels of Vitamin C, E and A Following Dietary Supplementation with a Combination of Glutathione and Resveratrol Precursors. Nutrients, 12.","DOI":"10.3390\/nu12113224"},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Bavetta, M., Silvaggio, D., Campione, E., Sollena, P., Formica, V., Coletta, D., Graziani, G., Romano MC, P., Roselli, M., and Peris, K. (2021). The Effects of Association of Topical Polydatin Improves the Preemptive Systemic Treatment on EGFR Inhibitors Cutaneous Adverse Reactions. J. Clin. Med., 10.","DOI":"10.3390\/jcm10030466"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10735-020-09930-4","article-title":"Polydatin and polydatin-loaded chitosan nanoparticles attenuate diabetic cardiomyopathy in rats","volume":"52","author":"Mostafa","year":"2021","journal-title":"J. Mol. Histol."},{"key":"ref_239","first-page":"1805","article-title":"Novel nanoliposomal delivery system for polydatin: Preparation, characterization, and in vivo evaluation","volume":"9","author":"Wang","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1903138","DOI":"10.1002\/advs.201903138","article-title":"Nanodrug with ROS and pH Dual-Sensitivity Ameliorates Liver Fibrosis via Multicellular Regulation","volume":"7","author":"Lin","year":"2020","journal-title":"Adv. Sci."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1039\/c1mb05087g","article-title":"Effect of ZnO# ZnS QDs heterojunctures on the stilbenes\u2013plasma proteins interactions","volume":"7","author":"Xiao","year":"2011","journal-title":"Mol. BioSystems"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.pharep.2019.02.017","article-title":"Protective effects of polydatin in free and nanocapsulated form on changes caused by lipopolysaccharide in hippocampal organotypic cultures","volume":"71","author":"Szczepanowicz","year":"2019","journal-title":"Pharmacol. Rep."},{"key":"ref_243","first-page":"179","article-title":"Hepatoprotective Effects of Polydatin-Loaded Chitosan Nanoparticles in Diabetic Rats: Modulation of Glucose Metabolism, Oxidative Stress, and Inflammation Biomarkers","volume":"86","author":"Yousef","year":"2021","journal-title":"Biochemistry"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.ijbiomac.2019.11.031","article-title":"Novel polydatin-loaded chitosan nanoparticles for safe and efficient type 2 diabetes therapy: In silico, in vitro and in vivo approaches","volume":"154","author":"Yousef","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s40200-020-00699-7","article-title":"Polydatin-loaded chitosan nanoparticles ameliorates early diabetic nephropathy by attenuating oxidative stress and inflammatory responses in streptozotocin-induced diabetic rat","volume":"19","year":"2020","journal-title":"J. Diabetes Metab. Disord."},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Vijayalakshmi, S., Mariadoss AV, A., Ramachandran, V., Shalini, V., Agilan, B., Sangeetha, C.C., Balu, P., Kotakadi, V.S., Karthikkumar, V., and Ernest, D. (2019). Polydatin encapsulated poly [lactic-co-glycolic acid] nanoformulation counteract the 7, 12-dimethylbenz [a] anthracene mediated experimental carcinogenesis through the inhibition of cell proliferation. Antioxidants, 8.","DOI":"10.3390\/antiox8090375"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"e22869","DOI":"10.1002\/jbt.22869","article-title":"Polydatin gold nanoparticles potentiate antitumor effect of doxorubicin in Ehrlich ascites carcinoma-bearing mice","volume":"35","author":"Samra","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"4969","DOI":"10.2147\/IJN.S252027","article-title":"Polyphenol-conjugated bimetallic Au@ AgNPs for improved wound healing","volume":"15","author":"Orlowski","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_249","doi-asserted-by":"crossref","unstructured":"Magalh\u00e3es, P.R., Reis, P.B., Vila-Vi\u00e7osa, D., Machuqueiro, M., and Victor, B.L. (2021). Identification of Pan-Assay INterference compoundS (PAINS) Using an MD-Based Protocol. Computational Design of Membrane Proteins, Springer.","DOI":"10.1007\/978-1-0716-1468-6_15"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1038\/s41598-021-83032-3","article-title":"C-Glucosylation as a tool for the prevention of PAINS-induced membrane dipole potential alterations","volume":"11","author":"Sousa","year":"2021","journal-title":"Sci. Rep."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/19\/6474\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:45:03Z","timestamp":1760143503000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/19\/6474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,1]]},"references-count":250,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["molecules27196474"],"URL":"https:\/\/doi.org\/10.3390\/molecules27196474","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,1]]}}}