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This study shows the enantioselective conjugate addition of ketones to maleimides organocatalyzed by a simple primary amine-salicylamide derived from a chiral trans-cyclohexane-1,2-diamine, which provides the desired succinimides in good to excellent yields (up to 98%) and with moderate to excellent enantioselectivities (up to 99%).<\/jats:p>","DOI":"10.3390\/molecules27196668","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T23:31:43Z","timestamp":1665358303000},"page":"6668","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Asymmetric Conjugate Addition of Ketones to Maleimides Organocatalyzed by a Chiral Primary Amine-Salicylamide"],"prefix":"10.3390","volume":"27","author":[{"given":"Alejandro","family":"Torregrosa-Chinillach","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Sciences, Institute of Organic Synthesis (ISO), University of Alicante, Apdo. 99, 03080 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9894-1671","authenticated-orcid":false,"given":"Rafael","family":"Chinchilla","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Sciences, Institute of Organic Synthesis (ISO), University of Alicante, Apdo. 99, 03080 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1016\/j.bmc.2005.04.054","article-title":"Methyllycaconitine analogues have mixed antagonist effects at nicotinic acetylcholine receptors","volume":"13","author":"Barker","year":"2005","journal-title":"Bioorg. 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