{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:45:36Z","timestamp":1762177536238,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T00:00:00Z","timestamp":1665273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"KAKENHI from the Japan Society for the Promotion of Science (JSPS)","award":["20K09885","5U54MD007592"],"award-info":[{"award-number":["20K09885","5U54MD007592"]}]},{"name":"National Institutes on Minority Health and Health Disparities (NIMHD), a component of the National Institutes of Health (NIH)","award":["20K09885","5U54MD007592"],"award-info":[{"award-number":["20K09885","5U54MD007592"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Two series of novel unsymmetrical 3,5-bis(benzylidene)-4 piperidones 2a\u2013f and 3a\u2013e were designed as candidate antineoplastic agents. These compounds display potent cytotoxicity towards two colon cancers, as well as several oral squamous cell carcinomas. These compounds are less toxic to various non-malignant cells giving rise to large selectivity index (SI) figures. Many of the compounds are also cytotoxic towards CEM lymphoma and HL-60 leukemia cells. Representative compounds induced apoptotic cell death characterized by caspase-3 activation and subG1 accumulation in some OSCC cells, as well as the depolarization of the mitochondrial membrane potential in CEM cells. A further line of inquiry was directed to finding if the SI values are correlated with the atomic charges on the olefinic carbon atoms. The potential of these compounds as antineoplastic agents was enhanced by an ADME (absorption, distribution, metabolism, and excretion) evaluation of five lead molecules, which revealed no violations.<\/jats:p>","DOI":"10.3390\/molecules27196718","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T23:31:43Z","timestamp":1665358303000},"page":"6718","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Novel Unsymmetric 3,5-Bis(benzylidene)-4-piperidones That Display Tumor-Selective Toxicity"],"prefix":"10.3390","volume":"27","author":[{"given":"Aruna","family":"Chhikara","sequence":"first","affiliation":[{"name":"Department of Chemistry, Dyal Singh College, University of Delhi, New Delhi 110003, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-5790","authenticated-orcid":false,"given":"Praveen 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