{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:55:31Z","timestamp":1791593731369,"version":"4.3.4"},"reference-count":147,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T00:00:00Z","timestamp":1665273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Princess Nourah bint Abdulrahman University"},{"name":"Mumbai University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This study investigated the effects of syringic acid (SA) on renal, cardiac, hepatic, and neuronal diabetic complications in streptozotocin-induced neonatal (nSTZ) diabetic rats. STZ (110 mg\/kg i.p) was injected into Wistar rat neonates as a split dose (second and third postnatal day). Diabetes mellitus was diagnosed in adults by measuring fasting blood glucose levels, urine volume, and food and water intake. The treatment of SA (25 mg\/kg, 50 mg\/kg p.o) was given from the 8th to 18th postnatal week. To assess the development of diabetic complications and the effect of therapy, biochemical indicators in serum and behavioural parameters were recorded at specific intervals during the study period. SA (25 mg\/kg, 50 mg\/kg p.o) treatment reduced hyperglycaemia, polydipsia, polyphagia, polyuria, relative organ weight, cardiac hypertrophic indices, inflammatory markers, cell injury markers, glycated haemoglobin, histopathological score, and oxidative stress, and increased Na\/K ATPase activity. These findings suggest that SA might significantly alleviate diabetic complications and\/or renal, neuronal, cardiac, and hepatic damage in nSTZ diabetic rats.<\/jats:p>","DOI":"10.3390\/molecules27196722","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T23:31:43Z","timestamp":1665358303000},"page":"6722","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Syringic Acid Ameliorates Cardiac, Hepatic, Renal and Neuronal Damage Induced by Chronic Hyperglycaemia in Wistar Rats: A Behavioural, Biochemical and Histological Analysis"],"prefix":"10.3390","volume":"27","author":[{"given":"Anwarbaig C.","family":"Mirza","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Institute of Pharmacy, Nirma University, Sarkhej-Ghandinagar Highway, Ahmedabad 382481, Gujarat, India"},{"name":"Department of Pharmacology, School of Pharmacy, AI\u2019s Kalsekar Technical Campus, Navi Mumbai 410206, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shital S.","family":"Panchal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Pharmacy, Nirma University, Sarkhej-Ghandinagar Highway, Ahmedabad 382481, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Allam","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah I.","family":"Othman","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Satia","sequence":"additional","affiliation":[{"name":"Ethicare Clinical Trial Services, Ahmedabad 380015, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay N.","family":"Mandhane","sequence":"additional","affiliation":[{"name":"Biological Research Pharmacology Department, Sun Pharma Advanced Research Company Ltd., Vadodara 390010, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,9]]},"reference":[{"key":"ref_1","unstructured":"(2022, March 05). 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