{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:05:01Z","timestamp":1768010701880,"version":"3.49.0"},"reference-count":54,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Agence Nationale de la Recherche","award":["2020 07132"],"award-info":[{"award-number":["2020 07132"]}]},{"name":"French Agence Nationale de la Recherche","award":["TURSP-2020\/310"],"award-info":[{"award-number":["TURSP-2020\/310"]}]},{"name":"Taif University","award":["2020 07132"],"award-info":[{"award-number":["2020 07132"]}]},{"name":"Taif University","award":["TURSP-2020\/310"],"award-info":[{"award-number":["TURSP-2020\/310"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The current study focused on the laboratory approach in conjunction with computational methods for the synthesis and bioactivity assessment of unique 2-tetradecanoylimino-3-aryl-4-methyl-1,3-thiazolines (2a\u20132k). Processes included cyclizing 1-aroyl-3-arylthioureas with propan-2-one in the presence of trimethylamine and bromine. By using spectroscopic techniques and elemental analyses, structures were elucidated. To assess the electronic properties, density functional theory (DFT) calculations were made, while binding interactions of synthesized derivatives were studied by the molecular docking tool. Promising results were found during the evaluation of bioactivity of synthesized compounds against alkaline phosphatase. The drug likeliness score, an indicator used for any chemical entity posing as a drug, was within acceptable limits. The data suggested that most of the derivatives were potent inhibitors of alkaline phosphatase, which in turn may act as lead molecules to synthesize derivatives having desired pharmacological profiles for the treatment of specific diseases associated with abnormal levels of ALPs.<\/jats:p>","DOI":"10.3390\/molecules27196766","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:50:01Z","timestamp":1665449401000},"page":"6766","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring 2-Tetradecanoylimino-3-aryl-4-methyl-1,3-thiazolines Derivatives as Alkaline Phosphatase Inhibitors: Biochemical Evaluation and Computational Analysis"],"prefix":"10.3390","volume":"27","author":[{"given":"Aftab","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajid-ur","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-7234","authenticated-orcid":false,"given":"Syeda Abida","family":"Ejaz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aamer","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabail","family":"Ujan","sequence":"additional","affiliation":[{"name":"Dr. M. A. Kazi Institute of Chemistry, University of Sindh, Jamshoro 66020, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pervaiz Ali","family":"Channar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan"},{"name":"Department of Basic Sciences, Mathematics and Humanities, Dawood University of Engineering and Technology, Karachi 74800, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalida","family":"Mahar","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Shah Abdul Latif University, Khairpur 66020, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reshma","family":"Sahito","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Sindh, Jamshoro 75500, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0774-5550","authenticated-orcid":false,"given":"Sarah M.","family":"Albogami","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-0798","authenticated-orcid":false,"given":"Qamar","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, University of Bahrain, Sakhir 32038, Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4326-6066","authenticated-orcid":false,"given":"Mohammed","family":"Alorabi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2782-9615","authenticated-orcid":false,"given":"Michel De","family":"Waard","sequence":"additional","affiliation":[{"name":"Smartox Biotechnology, 6 Rue des Platanes, 38120 Saint-Egr\u00e8ve, France"},{"name":"L\u2019institut du Thorax, INSERM, CNRS, Universit\u00e9 de Nantes, 44007 Nantes, France"},{"name":"LabEx \u00abIon Channels, Science & Therapeutics\u00bb, Universit\u00e9 de Nice Sophia-Antipolis, 06560 Valbonne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-425X","authenticated-orcid":false,"given":"Gaber El-Saber","family":"Batiha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour City 22511, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"ref_1","unstructured":"Lowe, D., Sanvictores, T., and John, S. 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