{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:24:47Z","timestamp":1788391487951,"version":"build-2803163510"},"reference-count":130,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Saponins are triterpenoid or steroidal glycosides and are an important group of naturally occurring compounds of plant origin. They exhibit diverse pharmacological potentials including radical scavenging, as well as neuroprotective, anti-diabetic and anti-inflammatory activities, owing to their diverse chemical scaffolds. Saponins consist of an aglycone part (non-sugar) and a glycone part (sugar) and have at least one glycosidic (C\u2013O sugar bond) linkage present between the glycone and aglycone mostly at C-3. On the basis of the aglycone part, saponins are classified into triterpenoid glycosides, steroid glycosides and alkaloid glycosides. Saponins exhibit neuroprotective activities against various disorders of the central nervous system (CNS) including stroke, Alzheimer\u2019s disease (AD), Huntington\u2019s disease (HD) and Parkinson\u2019s disease (PD). They mediate their therapeutic effects by modulation of various pathological targets. This study highlights various neuroprotective mechanisms of saponins including free radical scavenging, modulation of neuroprotective signaling pathways, activation of neurotrophic factors, modulation of neurotransmitters, inhibition of BACE1 enzyme and tau hyper-phosphorylation. The study concludes that saponins have considerable efficacy against various pathological targets of neurological disorders, especially AD, and might be an important source of leads against neurodegenerative disorders.<\/jats:p>","DOI":"10.3390\/molecules27206804","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T02:10:27Z","timestamp":1665540627000},"page":"6804","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Alzheimer\u2019s Disease as a Major Public Health Concern: Role of Dietary Saponins in Mitigating Neurodegenerative Disorders and Their Underlying Mechanisms"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1894-5382","authenticated-orcid":false,"given":"Asaad A.","family":"Abduljawad","sequence":"first","affiliation":[{"name":"Public Health Department, Health Sciences College at Al Leith, Umm Al Qura University, Mecca 24382, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6060-5533","authenticated-orcid":false,"given":"Mohammed Ahmed","family":"Elawad","sequence":"additional","affiliation":[{"name":"Public Health Department, Health Sciences College at Al Leith, Umm Al Qura University, Mecca 24382, Saudi Arabia"},{"name":"Faculty of Public and Environmental Health, University of Khartoum, Khartoum 11115, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Modawy Elnour Modawy","family":"Elkhalifa","sequence":"additional","affiliation":[{"name":"Public Health Department, Health Sciences College at Al Leith, Umm Al Qura University, Mecca 24382, Saudi Arabia"},{"name":"Faculty of Public and Environmental Health, University of Khartoum, Khartoum 11115, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8083-9145","authenticated-orcid":false,"given":"Alshebli","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Public Health Department, Health Sciences College at Al Leith, Umm Al Qura University, Mecca 24382, Saudi Arabia"},{"name":"Faculty of Public and Environmental Health, University of Khartoum, Khartoum 11115, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alashary Adam Eisa","family":"Hamdoon","sequence":"additional","affiliation":[{"name":"Public Health Department, Health Sciences College at Al Leith, Umm Al Qura University, Mecca 24382, Saudi Arabia"},{"name":"Faculty of Public and Environmental Health, University of Khartoum, Khartoum 11115, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liga Hasan Mohammed","family":"Salim","sequence":"additional","affiliation":[{"name":"Public Health Department, Health Sciences College at Al Leith, Umm Al Qura University, Mecca 24382, Saudi Arabia"},{"name":"Faculty of Public and Environmental Health, University of Khartoum, Khartoum 11115, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara 18000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4299-2445","authenticated-orcid":false,"given":"Muhammad","family":"Ayaz","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara 18000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-6540","authenticated-orcid":false,"given":"Syed Shams ul","family":"Hassan","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China"},{"name":"Department of Natural Product Chemistry, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3236-1292","authenticated-orcid":false,"given":"Simona","family":"Bungau","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1056\/NEJMe2103722","article-title":"Progress with treatments for Alzheimer\u2019s disease","volume":"384","author":"Levey","year":"2021","journal-title":"N. 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