{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:09:36Z","timestamp":1787162976443,"version":"build-2736575974"},"reference-count":56,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science, Technology and Innovation","award":["RC-FP44842-212-2018"],"award-info":[{"award-number":["RC-FP44842-212-2018"]}]},{"name":"Ministry of Education","award":["RC-FP44842-212-2018"],"award-info":[{"award-number":["RC-FP44842-212-2018"]}]},{"name":"Ministry of Industry, Commerce and Tourism","award":["RC-FP44842-212-2018"],"award-info":[{"award-number":["RC-FP44842-212-2018"]}]},{"name":"ICETEX, Programme Ecosistema Cient\u00edfico-Colombia Cient\u00edfica, from the Francisco Jos\u00e9 de Caldas Fund","award":["RC-FP44842-212-2018"],"award-info":[{"award-number":["RC-FP44842-212-2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Currently, there are no therapies to prevent severe dengue disease. Essential oils (EOs) can serve as primary sources for research and the discovery of phytomedicines for alternative therapy. Fourteen EOs samples were obtained by distillation from six plants used in Colombian folk medicine. GC\/MS analysis identified 125 terpenes. Cytopathic effect (CPE) reduction assays revealed differences in antiviral activity. EOs of Lippia alba, citral chemotype and carvone-rich fraction; Lippia origanoides, phellandrene chemotype; and Turnera diffusa, exhibited strong antiviral activity (IC50: 29 to 82 \u00b5g\/mL; SI: 5.5 to 14.3). EOs of Piper aduncum, Ocimum basilicum, and L. origanoides, carvacrol, and thymol chemotypes, exhibited weak antiviral activity (32 to 53% DENV-CPE reduction at 100 \u00b5g\/mL; SI &gt; 5.0). Cluster and one-way ANOVA analyses suggest that the strong antiviral activity of EOs could be attributed to increased amounts of non-phenolic oxygenated monoterpenes and sesquiterpene hydrocarbons. Docking analyses (AutoDock Vina) predicted binding affinity between the DENV-2 E protein and terpenes: twenty sesquiterpene hydrocarbons (\u22128.73 to \u22126.91 kcal\/mol), eight oxygenated monoterpenes (\u22127.52 to \u22126.98 kcal\/mol), and seven monoterpene hydrocarbons (\u22127.60 to \u22126.99 kcal\/mol). This study reports for the first time differences in the antiviral activity of EOs against DENV, corresponding to their composition of monoterpenes and sesquiterpenes.<\/jats:p>","DOI":"10.3390\/molecules27206844","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T22:45:29Z","timestamp":1665614729000},"page":"6844","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Essential Oils from Colombian Plants: Antiviral Potential against Dengue Virus Based on Chemical Composition, In Vitro and In Silico Analyses"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5503-5057","authenticated-orcid":false,"given":"Lina","family":"Silva-Trujillo","sequence":"first","affiliation":[{"name":"Centro de Cromatograf\u00eda y Espectrometr\u00eda de Masas, CROM-MASS, Universidad Industrial de Santander, Bucaramanga 680002, Santander, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3372-4710","authenticated-orcid":false,"given":"Elizabeth","family":"Quintero-Rueda","sequence":"additional","affiliation":[{"name":"Centro de Cromatograf\u00eda y Espectrometr\u00eda de Masas, CROM-MASS, Universidad Industrial de Santander, Bucaramanga 680002, Santander, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7052-932X","authenticated-orcid":false,"given":"Elena E.","family":"Stashenko","sequence":"additional","affiliation":[{"name":"Centro de Cromatograf\u00eda y Espectrometr\u00eda de Masas, CROM-MASS, Universidad Industrial de Santander, Bucaramanga 680002, Santander, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Conde-Ocazionez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Masira, Facultad de Ciencias de la Salud, Universidad de Santander, Bucaramanga 680003, Santander, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8209-3885","authenticated-orcid":false,"given":"Paola","family":"Rond\u00f3n-Villarreal","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Masira, Facultad de Ciencias de la Salud, Universidad de Santander, Bucaramanga 680003, Santander, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel E.","family":"Ocazionez","sequence":"additional","affiliation":[{"name":"Centro de Cromatograf\u00eda y Espectrometr\u00eda de Masas, CROM-MASS, Universidad Industrial de Santander, Bucaramanga 680002, Santander, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100712","DOI":"10.1016\/j.eclinm.2020.100712","article-title":"Global, regional, and national dengue burden from 1990 to 2017: A systematic analysis based on the global burden of disease study 2017","volume":"32","author":"Zeng","year":"2021","journal-title":"EClinicalMedicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2149\/tmh.2011-S10","article-title":"Clinical manifestations and management of dengue\/DHF\/DSS","volume":"39","author":"Kalayanarooj","year":"2011","journal-title":"Trop. 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